CAS: 1225-64-5; 3-(2-Chloro-10H-Phenothiazin-10-yl)-N-Methylpropan-1-Amine

相似化合物

19077-20-4 17140-12-4 2095-20-7

上下游产品

methyl-3-chloropropylamine 2-chlorophenothiazine N-[3-(2-chloro-phenothiazin-10-yl)-propyl]-formamideN-[3-(2-chloro-phenothiazin-10-yl)-propyl]-formamide 2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine3-(2-chloro-10H-phenothiazin-10-yl)-N-methyl-N-(4-(3-(piperidin-1-yl)propoxy)benzyl)-propan-1-amine N-[3-(2-chlorophenothiazin-10-yl)propyl]-2-(3,4-dimethoxyphenyl)-N-methylacetamide 3-(2-chlorophenothiazin-10-yl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-N-methylpropan-1-amine 3-(2-chlorophenothiazin-10-yl)-N-[2-(4-methoxyphenyl)ethyl]-N-methylpropan-1-amine

📜盐酸氯丙嗪置于1,8-双二甲氨基萘体系中,用 1,2-二氯乙烷 用作溶剂,化学反应 3.0H,反应生成去甲氯丙嗪
参考文献:Nb 06: From A Simple Lysosomotropic Asmase Inhibitor To Tools For Elucidating The Role Of Lysosomes In Signaling Apoptosis And Lps-Induced Inflammation
标题:Nb 06: From A Simple Lysosomotropic Asmase Inhibitor To Tools For Elucidating The Role Of Lysosomes In Signaling Apoptosis And Lps-Induced Inflammation
摘要:Ceramide Generation Is Involved In Signal Transduction Of Cellular Stress Response,In Particular During Stress-Induced Apoptosis In Response To Stimuli Such As Minimally Modified Low-Density Lipoproteins,Tnfalpha And Exogenous C-6-Ceramide. In This Paper We Describe 48 Diverse Synthetic Products And Evaluate Their Lysosomotropic And Acid Sphingomyelinase Inhibiting Activities In Macrophages. A Stimuli Induced Increase Of C-16-Ceramide In Macrophages Can Be Almost Completely Suppressed By Representative Compound Nb 06 Providing An Effective Protection Of Macrophages Against Apoptosis. Compounds Like Nb 06 Thus Offer Highly Interesting Fields Of Application Besides Prevention Of Apoptosis Of Macrophages In Atherosclerotic Plaques In Vessel Walls. Most Importantly,They Can Be Used For Blocking Ph Dependent Lysosomal Processes And Enzymes In General As Well As For Analyzing Lysosomal Dependent Cellular Signaling. Modulation Of Gene Expression Of Several Prominent Inflammatory Messengers Il1B,Il6,Il23A,Ccl4 And Ccl20 Further Indicate Potentially Beneficial Effects In The Field Of (Systemic) Infections Involving Bacterial Endotoxins Like Lps Or Infections With Influenza A Virus. (C) 2017 Elsevier Masson Sas. All Rights Reserved.
Doi:10.1016/j.Ejmech.2017.09.021