📜2-(羟基乙基)-6-甲基吡啶置于氢氧化钾,Palladium On Activated Charcoal,乙醇体系中,化学反应生成2-乙基-6-甲基吡啶 参考文献:Prasad; Raper,Journal Of The Chemical Society,1956,P. 217 标题:Prasad; Raper,Journal Of The Chemical Society,1956,P. 217
专利号:US-5110929-A 优先权日:1986-08-07 标题 :Process for the preparation of N-alkylated quaternary nitrogen containing aromatic heterocycles 发明人:PARADIES HENRICH H 权利人:MEDICE CHAM PHARM FABRIK PUTTE 摘要:The synthesis of 4-, 4-(1,1)-and 3,5-substituted N-alkyl-pyridinium salts as well as of 2-carboxamide substituted N(1,4)diazinium compounds are described. The N-surfactants obtained have a small critical micelle concentration (CMC) of 10-5 -10-7 Mol/Liter. These surfactants produce micells of different size and form depending on the nature of the anions. 4-(1,1)-substituted and 3,5-substituted N-alkyl-pyridinium components are capable of forming vesicles in equeous solutions of different forms and sizes. The N-surfactants synthesized can be used as pharmaceuticals.
专利号:US-3950416-A 优先权日:1967-11-24 标题 :Synthesis of dicyanoformamides 发明人:PATTON TAD L 权利人:EXXON RESEARCH ENGINEERING CO 摘要:Dicyanoformamides having aromatic moieties as novel composition of matter are prepared by the reaction of a diisocyanate having an aromatic moiety with two (2) moles of hydrogen cyanide in the presence of a specially defined, hindered catalyst which will not promote further polymerization.
专利号:US-7002006-B2 优先权日:2003-02-12 标 题:Protection of nucleosides 发明人:SONG QUANLAI; ROSS BRUCE S 权利人:ISIS PHARMACEUTICALS INC 摘要:A process of manufacturing protected nucleosides comprises reacting a nucleoside with a protecting reagent in the presence of a regioselective activator to produce a regioselectively protected nucleoside. In some embodiments of the inventive method, an optionally substituted trityl or optionally substituted pixyl group is selectively added to the 5'-O-position of a nucleoside in the presence of lutidine as activator or activator/solvent. The inventive method results in improved selectivity of the 5'-O-position over the 3'-O-position, thereby improving overall product yield and purity, and permitting simplified purification protocols, in some cases obviating the need for chromatography to produce a purified protected nucleoside suitable for automated synthesis of oligonucleotides, such as primers, probes and antisense molecules.
专利号:US-9394387-B2 优先权日:2014-05-15 标 题:Synthesis of aryl coupled bis phenoxides and their use in olefin polymerization catalyst systems with activator-supports
专利号:US-6469172-B2 优先权日:2000-03-08 标题:Process for the preparation of chemical compounds 发明人:MALIGRES PETER E; LEE JAEMOON 权利人:MERCK & CO INC 摘要:An improved and efficient synthesis for the preparation of 2-amino-6-[(4-aminopiperidin-1-yl]methyl]pyridine, an intermediate compound in the preparation of muscarinic M3 receptor antagonists, includes as a final step the removal of trimethylacetyl and an amino protecting group from 2-trimethylacetyl-amino-6-[(4-protected aminopiperidin-1-yl)methyl]pyridine.
专利号:US-9714260-B2 优先权日:2013-01-07 标 题:Asymmetrical Si rhodamine and rhodol synthesis 发明人:NAGANO TETSUO; HANAOKA KENJIRO; EGAWA TAKAHIRO; KUSHIDA Yu; NUMASAWA Koji; MYOCHIN Takuya; PIAO Wen 权利人:UNIV TOKYO 摘要:[Problem] To provide: a compound resulting from substituting with a silicon atom the oxygen atom at position 10 of a xanthene ring site of a rhodamine of which amino groups at position 3 and position 6 have an asymmetrical structure; a method for producing the compound; and a fluorescent probe that uses the compound. n [Solution] The compound represented by general formula (I) or a salt thereof.