CAS: 108-75-8; 2,4,6-Trimethylpyridine

相似化合物

39965-81-6 18206-06-9 30413-56-0

上下游产品

CAS号1123-09-7 3,5-二甲基-2-环己烯-1-酮 | CAS号3376-50-9 2,4,6-三甲基558-1-氧化物 | CAS号940-93-2 2,4,6-Trimethyl... | CAS号75-07-0 乙醛 | CAS号67-64-1 丙酮 | CAS号3102-33-8 (E)-3-戊烯-2-酮 | CAS号773-01-3 2,4,6-三甲基吡喃鎓四氟硼酸盐 | CAS号63681-01-6 1,2-Dihydro-2,2... | CAS号18368-63-3 2-氯-6-甲基吡啶 | CAS号702-16-9 5-丁基-2-甲基吡啶 | CAS号37413-91-5 21-羟基孕甾-1,4,9(1... | CAS号5389-87-7 香叶基氯 | CAS号566-93-8 4,6-胆固醇二烯-3-酮 | CAS号566-91-6 Cholesta-1,4-di... | CAS号3840-27-5 2,5-二甲氧基苄氯 | CAS号54221-93-1 2,6-二甲基-4-吡啶甲酸 | CAS号7726-95-6 溴素 | CAS号493-77-6 2,4,6-三苯基三嗪 | CAS号84737-93-9 N-(dimethyl-4,6...

丙酮置于氨体系中,134.5~237.5 °C,11.9 Mpa 条件下,以84%的收率获得2,4,6-三甲基吡啶
参考文献:一种基于超临界流体技术的2,4,6-三甲基吡啶的生产方法
标题:一种基于超临界流体技术的2,4,6-三甲基吡啶的生产方法
摘要:本发明提供一种基于超临界流体技术的2,4,6‑三甲基吡啶的生产方法,包括以下步骤:将催化剂和丙酮加入超临界反应釜中,搅拌均匀,将液氨压入反应釜中,先加压加热使液氨达到超零界状态,再继续加压加热使丙酮达到超零界状态,快速冷却降温,终止反应,得到基于超临界流体技术的2,4,6‑三甲基吡啶初品;或者将丙酮加入超临界反应釜中,将液氨压入反应釜中,先加压加热使液氨达到超零界状态,再继续加压加热使丙酮达到超零界状态,快速冷却降温,终止反应,得到基于超临界流体技术的2,4,6‑三甲基吡啶初品;最后将2,4,6‑三甲基吡啶初品通过精馏分水,得到基于超临界流体技术的2,4,6‑三甲基吡啶.本发明制备方法简单,反应高效,产物的收率和纯度高.

专利信息

专利号:US-9920084-B2
优先权日:2011-08-23
标题 :Ionic tags for synthesis of oligoribonucleotides
发明人：DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK-HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER
权利人:DAMHA MASAD J; HASSLER MATTHEW; CHAN TAK HANG; NANDYALA MALLIKARJUNA REDDY; DONGA ROBERT ALEXANDER; THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV; HONG KONG POLYTECHNIC UNIV
摘要:The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.

专利号:US-7301006-B2
优先权日:2002-07-16
标 题 :Methods and materials for the synthesis of modified peptides
发明人：YOUNG TRAVIS G; KIESSLING LAURA L
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Methods and protected amino acids useful as building blocks (protected monomers) for the synthesis of peptides and proteins that are selectively modified at one or more side-chain hydroxyl groups. Azide-bearing protecting groups allow the selective deprotection of side-chain hydroxyl groups of amino acids after synthesis of a peptide. Reaction conditions for removal of the azide-bearing protecting group can be selected which are substantially orthogonal to those that will remove α-amino protecting groups typically employed in peptide synthesis, such that hydroxyl groups protected with the azide-bearing protecting group remain protected during synthesis of the peptide chain. Various protecting groups which are readily available can be used for protecting potentially reactive side chain groups of amino acids in the peptide or protein to be modified. Preferred side-chain protecting groups are chemically distinguishable from the azide-bearing protecting group and substantially orthogonal reaction conditions can be selected such that side-chain protection of other amino acids is maintained when the azide-bearing protecting group is removed. The use of the azide-bearing protecting group of this invention for one or more hydroxy amino acids during peptide synthesis allows the selective unmasking of those azide-protected side-chain hydroxyl groups and selective modification of the hydroxyl groups that are selectively unmasked. The methods and materials herein are particularly used in synthesis of sulfated, phosphorylated and glycosylated peptides and proteins. Kits and methods of synthesizing a modified peptide or protein using the kits are also provided.

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:WO-2024151344-A9
优先权日:2022-11-18
标题:A device that enables the combinatorial synthesis of small molecule libraries
发明人：COPELAND Gregory; LIU JANE
权利人:BRT BIOTECHNOLOGIES INC
摘要:A device for the synthesis of small molecules on a substrate is provided. The device includes a synthesis plate with vias, and a microfluidic patterning plate with a series ot open-faced channels that can be aligned with the vias on the synthesis plate. The device may be used to synthesize combinatorial libraries of small molecules.

专利号:US-7241399-B2
优先权日:2000-09-08
标题 :Synthesis of nanoparticles
发明人：HAUBOLD STEPHAN; HAASE MARKUS; RIWOTZKI KARSTEN; WELLER HORST; MEYSSAMY HEIKE; IBARRA FERNANDO
权利人:CT ANGEWANDTE NANOTECH CAN
摘要:Methods for the preparation of inorganic nanoparticles capable of fluorescence, wherein the nanoparticles consist of a host material that comprises at least one dopant. The synthesis of the invention in organic solvents allows to gain a considerably higher yield compared to the prior art synthesis in water. All kinds of objects can advantageously be marked and reliably authenticated by using an automated method on the basis of a characteristic emission. Further, the size distribution of the prepared nanoparticles is nartower which renders a subsequent size-selected separation process superfluous.