专利号:US-7745471-B2 优先权日:2004-06-18 标题:Derivatives of 1,2-benzisoxazole-3-methane sulfonic acid as novel intermediates for the synthesis of zonisamide 发明人:NADDAKA VLADIMIR; KLOPFER EYAL; SAEED SHADY; ARAD ODED; KASPI JOSEPH 权利人:CHEMAGIS LTD 摘要:Derivatives of 1,2-benzisoxazole-3-methanesulfonic acid, which are non-hygroscopic and non-hydrated and their use as intermediates from the preparation of zonisamide are disclosed. Further disclosed are processes of preparing zonisamide from these 1,2-benzisoxazole-3-methanesulfonic acid derivatives, processes of preparing exemplary 1,2-benzisoxazole-3-methanesulfonic acid derivatives and crystalline forms of exemplary 2-benzisoxazole-3-methanesulfonic acid derivatives. A novel process of preparing zonisamide is also disclosed.
专利号:US-5759942-A 优先权日:1994-10-25 标 题:Ion exchange resin catalyst for the synthesis of bisphenols and the process for preparing the same 发明人:TAN QIU; JIN ZUQUAN; JIANG HONGSHOU; LIU ZONGZHANG; HE BINGJUN 权利人:CHINA PETROCHEMICAL CORP; UNIV TIANJIN 摘要:An ion exchange resin catalyst containing sulfonated styrene-divinylbenzene copolymer, a porous structure with micropore area and transfer pass networks, the transfer pass network is composed of main pass networks and branch pass networks, in non-swollen state, the pore size of the main pass network is 9x103-38x103 nanometer and the pore size of the branch pass network is 20-150 manometer, the pore size of the micropore area pass is 5-20 nanometer, wherein the pore capacity of the micropore pass with the pore size of 5-10.4 nm is more than 50% of the total pore capacity of the micropore area, and the ratio of the pore capacity of the micropore area to that of the transfer network area is 0.25-1.1. The catalyst is useful to condense phenols with ketones.
专利号:US-4929752-A 优先权日:1986-09-23 标题:Process for the preparation of 1-amine-2-naphthol-4-sulfonic acid 发明人:ALBRECHT BERNHARD; BEYRICH JUERGEN 权利人:CIBA GEIGY CORP 摘要:There is disclosed an improved semi-continuous and continuous process for the preparation of 1-amino-2-naphthol-4-sulfonic acid by nitrosation of 2-naphthol, addition of bisulfite, acidification with mineral acid and reduction of the reaction product so obtained, which comprises charging the reactor with the nitrosating agent and simultaneously adding 2-naphthol and mineral acid simultaneously in separate streams in the semi-continuous process, or charging the reactor with the reaction mass and simultaneously adding 2-naphthol, mineral acid and the nitrosating agent in separate streams in the continuous process. The product can be further used, without isolation, for the synthesis of dyes.
专利号:WO-2004094357-A1 优先权日:2003-04-23 标 题 :Method for producing ether using solid acid catalyst 发明人:FURUTA SATOSHI 权利人:JAPAN ENERGY CORP; FURUTA SATOSHI 摘要:A method for synthesizing an ether is disclosed which enables a reaction for producing an ether to proceed in a short reaction time at or about atmospheric pressure without heating to high temperatures. By bringing an alcohol in the gas phase into contact with a solid acid catalyst with super strong acid properties, synthesis of an ether proceeds with high efficiency. In this connection, it is preferable to bring the alcohol into contact with the solid acid catalyst at a gas space velocity of 1,500/hour or more in view of suppressing deterioration of the catalyst. It is also preferable that the alcohol has 1-2 carbon atoms and the temperature when the alcohol and the solid acid catalyst come into contact each other is not less than 100ËšC.
专利号:CH-91859-A 优先权日:1919-05-23 标题:Process for the preparation of a mixture of hydrogen and nitrogen suitable for the synthesis of ammonia.
专利号:US-5827855-A 优先权日:1992-12-28 标题 :Hexahydronaphthalene ester derivatives their preparation and their therapeutic uses 发明人:KOGEN HIROSHI; ISHIHARA SADAO; KOGA TEIICHIRO; KITAZAWA EIICHI; SERIZAWA NOBUFUSA; HAMANO KIYOSHI 权利人:SANKYO CO 摘要:Compounds of formula (I): (I) wherein R1 represents a group of formula (II) or (III): (II) (III) R2 is alkyl, alkenyl or alkynyl; R3 and R4 are each hydrogen, alkyl, alkenyl or alkynyl; R5 is hydrogen or a carboxy-protecting group; Ra is a group of formula -OR6; R6 is hydrogen; R6a and R6b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulfonyl, halogenated alkanesulfonyl or arysulfonyl, and their salts and esters. Such compounds inhibit the synthesis of cholesterol, and can be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.
摘要:Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-123 摘要:Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 88 摘要:Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. 22(83) 281 摘要:Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 3039 摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118