CAS: 827-08-7; 1,2-Dibromo-3,4,5,6-Tetrafluorobenzene

上下游产品

1,2,3,4-tetrafluorobenzene pentafluorophenyl lithium 1-bromo-2,3,4,5-tetrafluorobenzene 1-(trimethyl silyl) 2-bromo tetrafluoro benzene 2,2'-dibromo°Ctafluorobiphenyl 2-bromo-3,4,5,6-tetrafluorobenzoic acid 1-bromo-2,3,4,5-tetrafluorobenzene

2,3,4,5-四氟溴苯 反应生成 1,2-二溴四氟苯
参考文献:Process For The Preparation Of Tetrafluorohalogenbenzenes
标题:Process For The Preparation Of Tetrafluorohalogenbenzenes
摘要:本发明涉及一种制备式为(I)C6F4Hx的化合物的方法,其中x为br或cl,该方法包括在路易斯酸催化剂的存在下,将四氟苯与卤素反应.

专利信息

专利号:WO-8707267-A1
优先权日:1986-05-19
标 题:Method of synthesizing tetrafluorophthalonitrile
发明人：NALEWAJEK DAVID; LOCKYER GEORGE DONALD; EIBECK RICHARD ELMER; PYSZCZEK MICHAEL FRANCIS
权利人:ALLIED CORP
摘要:A process for the preparation of compounds of the general formula C6Fx(CN)y, wherein x and y are whole integers whose sum equals 6. The process is particularly useful for the synthesis of fluorinated nitriled containing at least two cyano groups (y=2). Among the preferred compounds prepared is tetrafluorophthalonitrile, a key intermediate used as a building block in the pharmaceutical industry. In the process described, tetrafluorophthalonitrile is prepared by the reaction of a chlorinated compound of general formula C6Clx(CN)y wherein x and y are whole integers whose sum equals 6. Specifically, tetrachlorophthalonitrile is reacted with potassium fluoride in an aprotic solvent to prepare tetrafluorophthalonitrile. The fluoronitrile is produced in at least 80 % yield and a minimum purity of 98.5 %. Only one additional recrystallization is required to produce a material of > 99.5 % purity. In another embodiment, the crude tetrafluorophthalonitrile is recrystallized from a hydrocarbon alkane solvent to produce a product of > 99.5 % purity which can be used directly as an intermediate. This process represents an economical means to produce tetrafluorophthalonitrile on an industrial scale.