CAS: 78592-82-2; (But-3-Yn-1-Yloxy)(Tert-Butyl)Dimethylsilane

相似化合物

927-74-2 61362-77-4 73448-13-2

上下游产品

tert-butyldimethylsilyl chloride 3-Butyn-1-ol t-butyldimethylsiyl triflate 1H-imidazole (E)-7-(tert-Butyl-dimethyl-silanyloxy)-1-phenyl-hept-4-en-2-ol (1E,3E)-9-(tert-Butyl-dimethyl-silanyloxy)-3-methyl-1-(2,6,6-trimethyl-cyclohex-1-enyl)-nona-1,3-dien-6-yn-5-ol ((E)-5-phenylpent-3-enyloxy)(tert-butyl)dimethylsilane (R)-7-(tert-Butyl-dimethyl-silanyloxy)-2-((1R,2S,6R)-6-isopropenyl-2-methoxymethoxy-4-methyl-cyclohex-3-enyl)-hept-4-yn-3-ol

Tert-Butyldimethyl(4-(Trimethylsilyl)But-3-Ynyloxy)Silane置于四丁基氟化铵体系中,用 四氢呋喃,甲醇 作为反应溶剂,化学反应生成 4-三甲基甲硅烷-3-丁炔-1-醇,4-(叔丁基二甲基硅杂氧基)-1-丁炔
参考文献:通过振动强耦合倾斜基态反应性景观
标题:通过振动强耦合倾斜基态反应性景观
摘要:改变反应位点选择性 将振动能放入化学键中应该促进该键的选择性断裂,这似乎很直观.事实上,振动激发与反应性的关系通常被证明更微妙和更复杂.托马斯等人.研究了特定振动模式与光学腔的强耦合可能会影响具有两个竞争反应位点的分子.该分子有两个硅中心,可以通过分别裂解 Si-C 或 Si-O 键与氟化物反应.在任一中心激发振动减慢了整体反应,同时有利于否则不利的 Si-O 裂解.科学,这个问题 P.615 振动模式与光腔的强耦合改变了竞争性甲硅烷基取代反应中的位点选择性.已经开发了许多化学方法来促进具有两个或多个反应位点的化合物的转化中的特定产物.我们使用反应物和微流体光学腔的真空场之间的振动强耦合 (Vsc) 探索了一种不同的位点选择性方法.具体而言,我们研究了具有两个可能的甲硅烷基键断裂位点(分别为 Si-C 和 Si-O)的化合物的反应性,作为在黑暗中三种不同振动模式的 Vsc 的函数.结果表明,Vsc
DOI:10.1126/science.Aau7742

专利信息

专利号:US-2025026768-A1
优先权日:2023-06-30
标题:Method for the synthesis of axially chiral organoboron compounds
发明人：PING YIFAN; CHE CHI-MING
权利人:LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
摘要:A highly efficient and atroposelective Rh-catalyzed [2+2+2] cycloaddition for the synthesis of axially chiral aryboron compounds is developed. The reactions of diynes and alkynylborons smoothly occur in an atom-economical manner, affording a variety of C—B atropisomers in excellent yields and enantioselectivities. The protocol features mild conditions, broad substrate scope, and good functional tolerance. The obtained C—B atropisomers show powerful synthetic applications in terms of producing novel chiral phosphine ligands.

专利号:US-6541647-B2
优先权日:1998-07-03
标 题:Methods of synthesis of substituted tetrahydrofuran compound
发明人：CHORGHADE MUKUND SHANKAR; GURJAR MUKUND KESHAO; KRISHNA PALAKODETY RADHA; LALITHA SISTA VENKATA SAI; SADALAPURE KASHINATH; ADHIKARI SUSANTA SEKHAR; MURUGAIAH ANDAPPAN MURUGAIAH S; MHASKAR SUNIL VYANKATESH; SHARMA GANGAVARAM VASANTHA MAD; PRASAD TANGALLAPALLY RAJENDRA; SREENIVAS PUNNA; REDDY VAVILALA GOVERDHAN; ISLAM AMINUL; PRASAD CHITTINENI HARI; RAO ALLA VENKATA RAMA
权利人:MILLENNIUM PHARM INC
摘要:The invention includes inter alia new methods for preparation of the pharmaceutically active compound 2-(4-fluorophenoxymethyl)-5-(4-N-hydroxyureidyl-1 -butynyl)-tetrahydrofuran and precursors thereof.

专利号:US-7402703-B2
优先权日:2005-06-08
标 题:Stereoselective synthesis of (E)-vinylboronic esters via a Zr mediated hydroboration of alkynes
发明人：WANG YANONG DANIEL
权利人:WYETH CORP
摘要:There is herein provided a process for Zr-mediated hydroboration of alkynes which offers (E)-vinylboronic esters in high yield with stereoselectivity and regioselectivity.

专利号:US-2006281943-A1
优先权日:2005-06-08
标题 :Stereoselective synthesis of (E)-vinylboronic esters via a Zr mediated hydroboration of alkynes

专利号:US-2010120784-A1
优先权日:2007-04-20
标题 :Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LACHANCE NICOLAS; LI CHUN SING; LECLERC JEAN-PHILPPE; RAMTOHUL YEEMAN K
权利人:LACHANCE NICOLAS; LI CHUN SING; LECLERC JEAN-PHILPPE; RAMTOHUL YEEMAN K
摘要:Heteroaromatic compounds of structural formula (I) or a pharmaceutically acceptable salt thereof, wherein W is a substituted heteroaryl, X and Y are each independently a bond, —O—, —S—, —S(O)—, —S(O) 2 —, —NR 6 —, —C(O)—, —C(CH 3 )(OH)— or —C(CH 3 )â•?CH—, u (I) is an integer from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis, obesity, Type 2 diabetes, insulin resistance, hyperglycemia, Metabolic Syndrome, neurological disease, cancer, and liver steatosis

专利号:WO-0001683-A1
优先权日:1998-07-03
标题:Methods for synthesis of substituted tetrahydrofuran compound