CAS: 78574-94-4; (2Ar,3R,4S,5As,5Bs,7S,7Ar,9S,11Ar,12As)-3-((2R,5S)-5-(2-Hydroxypropan-2-yl)-2-Methyltetrahydrofuran-2-yl)-2A,5A,8,8-Tetramethylhexadecahydrocyclopenta[a]Cyclopropa[e]Phenanthrene-4,7,9-Triol
该化合物是一种生物活性三元素化合物,产自Astragalus membrananceus, 一种传统用于草药的植物,具有调节调聚酶活动的潜力,可支持细胞长寿和减少氧化性压力. 丙烯丙烯丙烯醇具有很高的纯度和稳定性,适于研究在老龄化,免疫学和代谢健康方面的应用. 其分子机制包括激活调聚酶酶,该酶在保持染色体完整性方面发挥作用. 该化合物以标准化的形式提供,确保实验使用的一致性. 研究人员对丙烯丙烯醇研究与年龄有关途径的潜力及其在临床前模型中的适用性进行了评估.
- 英文名称(2Ar,3R,4S,5As,5Bs,7S,7Ar,9S,11Ar,12As)-3-((2R,5S)-5-(2-Hydroxypropan-2-yl)-2-Methyltetrahydrofuran-2-yl)-2A,5A,8,8-Tetramethylhexadecahydrocyclopenta[a]Cyclopropa[e]Phenanthrene-4,7,9-Triol
- 中文名称环黄芪醇
- IUPAC名称(2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethyltetradecahydro-1H,12H-cyclopenta[a]cyclopropa[e]phenanthrene-4,7,9-triol
- 其它别名9,19-Cyclolanostane-3,6,16,25-Tetrol, 20,24-Epoxy-, (3.Beta.,6.Alpha.,16.Beta.,20R,24S)-; Cyclogalegigenin; Astramembrangenin; (3Beta,6Alpha,16Beta,20R,24S)-20,24-Epoxy-9,19-Cyclolanostane-3,6,16,25-Tetrol
- CAS编号78574-94-4
- MFCD编号:MFCD24849201
- FDA UNII编号:X37D9F2L0V
- 分子式:C30H50O5分子量:490.73
- 产品CID: 1780412
- 同类组份化合物CAS78574-94-484605-18-5
- 产品分类天然产物 → 萜类
- 相似结构搜索
- InChIKey: WENNXORDXYGDTP-UOUCMYEWSA-N
- WENNXORDXYGDTP-XWIGRFCYNA-N
- 计算化学: 氢键受体数5.0氢键供体数4.0可旋转键数2.0
物理性质
- 熔点241.0 to 245.0 °C
- 沸点617.2±55.0 °C at 760 mmHg
- 闪点327.1±31.5 °C
- 密度1.2±0.1 g/cm3
- pKa:14.57±0.29(预测)
- PSA:90.15
- LogP:3.82
- 折射率1.582
- 蒸汽压0.0±4.0 mmHg at 25°C
- 溶解性Sparingly Soluble In Aqueous Buffers. For Maximum Solubility In Aqueous Buffers, First Dissolve In DMF And Then Dilute With The Aqueous Buffer Of Choice. Cycloastragenol Has A Solubility Of Approximately 0.25 mg/mL In A 1:8 Solution Of DMF:Pbs (Ph 7.2) Using This Method.Solubility In DMSO Is 98 mg/mL (199.7 Mm)
- 外观形态白色至几乎白色粉末至晶体
- 储存条件密封, 常温干燥保存
- 产品应用该化合物是一种分子,它与ASTRAGALUS GENUS 中各种物种分离,据称具有调聚酶活性. 对人类CD4和CD8 T细胞的单一体外研究导致人们声称,环氧乙烷可能会激活调聚醚,从而引发了对其在减少老化影响方面的作用的争议性主张.
上下游产品
Cycloaraloside A cycl°Carposide cycloaraloside E Cycloaraloside Fastragenol 37H54O6C37H54O6 44H67NO8C44H67NO8 44H67NO8C44H67NO8合成工艺路线路线简述
📜Cycloaraloside C置于硫酸体系中,用 甲醇 作为反应溶剂,化学反应 4.0H,反应生成 环黄芪醇
参考文献:黄芪的三萜糖苷和它们的genins Xxxv.来自黄芪的环芳甙c
标题:黄芪的三萜糖苷和它们的genins Xxxv.来自黄芪的环芳甙c
摘要:从植物黄芪的根中分离出一种新的环阿坦系列三萜糖苷(环芳烃苷 C).(豆科).cycloaraloside C 是一种包含一个 D-葡萄糖残基和一个 D-Apiose 残基的 Cyclosieversigenin 的生物苷.根据化学转化和光谱特征,糖苷的结构已显示为 20R,24S-Epoxycycloartane-3β,6α,16β,25-Tetraol 3-O-[o-(D-Apio-β-D-呋喃糖基)-(1-> 2)-β-D-吡喃葡萄糖苷].这是首次在环阿坦糖苷中发现 D-Apiose.
DOI:10.1007/bf00630078
专利信息
专利号:WO-2020222717-A1
优先权日:2019-04-30
标 题 :Ag-08 molecule that is a sapogenol derivative exhibitng cytotoxic effects by activating the necrosis pathway and synthesis method thereof
发明人：BEDÄ°R ERDAL; BALLAR KIRMIZIBAYRAK PETEK; TAÄž ÖZGÃœR; ERZURUMLU YALÇIN; ÃœNER GÖKLEM
权利人:IZMIR YUEKSEK TEKNOLOJI ENSTITUESUE; EGE UENIVERSITESI REKTOERLUEGUE
摘要:The invention is related to an AG-08 coded novel structured molecule having cytotoxic features against cancer cells. The aim of the invention is to primarily synthesize the astragenol (AG) molecule from cycloastragenol (CA) and then from here, the cytotoxic molecule coded AG-08 which enables to kill cancer cells via a pathway that is non-apoptotic as a difference from the compounds that exhibit traditional anticancer activity.
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Zeng JK, Li YY, Wang TM, Zhong J, Wu JS, Liu P, Zhang H, Ma YM. Simultaneous quantification of multiple components in rat plasma by UPLC-MS/MS and pharmacokinetic study after oral administration of Huangqi decoction. Biomed Chromatogr. 2017 Dec 15. doi: 10.1002/bmc.4178. [Epub ahead of print] doi: 10.3892/mmr.2017.7896. Epub 2017 Oct 26. doi: 10.1016/j.biopha.2017.08.115. Epub 2017 Sep 5. doi: 10.1007/s12010-017-2517-1. Epub 2017 Jun 7. doi: 10.3892/mmr.2017.6685. Epub 2017 Jun 6.
6: Li HF, Xu F, Yang P, Liu GX, Shang MY, Wang X, Yin J, Cai SQ. Systematic screening and characterization of prototype constituents and metabolites of total astragalosides using HPLC-ESI-IT-TOF-MS(n) after oral administration to rats. J Pharm Biomed Anal. 2017 Aug 5;142:102-112. doi: 10.1016/j.jpba.2017.05.009. Epub 2017 May 5. doi: 10.1016/j.phrs.2017.04.021. Epub 2017 Apr 18. doi: 10.1021/acs.joc.7b00080. Epub 2017 Mar 31. doi: 10.1080/08923973.2017.1300170. Epub 2017 Mar 14. Chinese. doi: 10.4103/0253-7613.194851.
12: Ran R, Zhang C, Li R, Chen B, Zhang W, Zhao Z, Fu Z, Du Z, Du X, Yang X, Fang Z. Evaluation and Comparison of the Inhibition Effect of Astragaloside IV and Aglycone Cycloastragenol on Various UDP-Glucuronosyltransferase (UGT) Isoforms. Molecules. 2016 Nov 29;21(12). pii: E1616. doi: 10.1111/bph.13631. Epub 2016 Oct 29. Review.
合成参考文献
参考文献:10.1016/j.jep.2012.12.010
摘要:Li T, Wang Y, Wang Y, Liang R, Zhang D, Zhang H, Chen L, Yang W. Development of an SPE–HPLC–MS method for simultaneous determination and pharmacokinetic study of bioactive constituents of Yu Ping Feng San in rat plasma after oral administration. Journal of Ethnopharmacology. 2013 Feb;145(3):784–92. doi: 10.1016/j.jep.2012.12.010.
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