CAS: 78350-50-2; 4-Amino-1,2,5-Oxadiazole-3-Carboxylic Acid

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156463-85-3 17376-63-5 159013-94-2

上下游产品

is°Cyanato-furazancarbonitrile 4-aminofurazan-3-carboxyamid-O-acetyloxime (cyano-furazan-3-yl)-carbamic acid thiadiazine 5,5-dioxide7-amino-4H-furazano3,4-c1,2,6thiadiazine 5,5-dioxide 4-oxo-4,5-dihydro-[1,2,5]oxadiazole-3-carboxylic acid ethyl 4-amino-1,2,5-oxadiazole-3-carboxylate 3,4-dicyano-1,2,5-oxadiazole 2-oxide methyl 3-aminofurazan-4-carboxylate

📜氰乙酸乙酯置于磷酸,盐酸羟胺,Potassium Hydroxide,Sodium Nitrite体系中,化学反应生成 3-氨基呋咱-4-羧酸
参考文献:基于呋喃山或4-硝基吡唑的非金属戊唑盐,可提高密度和稳定性
标题:基于呋喃山或4-硝基吡唑的非金属戊唑盐,可提高密度和稳定性
摘要:在这项工作中,三种新的非金属五唑盐(6-8)的基础上或呋咱-4-硝基吡唑合成.将一些共面基团引入化合物中以改善晶体堆积的平面度.4-氨基1,2,5-恶二唑-3-碳酰肼酰胺五唑酸酯(6),5-(4-氨基1,2,5-恶二唑-3-基)-4 H-1,2,4-三唑-3,4-二胺五唑酸酯(7)和5,5'-(4-硝基-1 H-吡唑-3,5-二基)-双(4 H-1,2,4-三唑-3,4-二胺)戊唑酸酯(8)均表现出比大多数其他报告的非金属戊唑盐(t发作)更稳定的π-π堆积和优异的热稳定性(110.5-116.4oc).:80-110oc),并且化合物8具有迄今为止非金属戊唑盐的最高晶体密度(1.722 G.cm-3 / 173 K).所有盐均已通过NMR(1 H和13 C)光谱,红外(ir),罗马(ra)和元素分析进行了全面表征.所有盐的分解温度均显示超过110°C,这是通过差示扫描量热法(d
DOI:10.1021/acs.Cgd.0C01574

专利信息

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.