CAS: 68077-26-9; 1-Ethyl-7-Chloro-6-Fluoro-1,4-Dihydro-4-Oxoquinoline-3-Carboxylic Acid

上下游产品

CAS号70458-94-5 7-氯-1-乙基-6-氟-1,... | CAS号70458-93-4 7-氯-6-氟-4-4羟基-3... | CAS号367-21-5 3-氯-4-氟苯胺 | CAS号70032-30-3 二乙基 2-(((3-氯-4-... | CAS号55330-56-8 beta-Ethylamino... | CAS号86393-34-2 2,4-二氯-5-氟苯甲酰氯 | CAS号106648-05-9 2-(2,4-Dichlor-... | CAS号70458-92-3 培氟沙星 | CAS号70458-96-7 氟哌酸 | CAS号75001-78-4 7-chloro-1-ethy... | CAS号74011-42-0 4-氧诺氟沙星 | CAS号140700-97-6 7-chloro-1-ethy... | CAS号70458-97-8 1-ethyl-6-fluor... | CAS号74011-56-6 7-(4-乙酰基哌嗪-1-基)... | CAS号75001-85-3 7-chloro-1-ethy... | CAS号68077-27-0 盐酸诺氟沙星

2,4-二氯-5-氟苯酰氯置于盐酸,Potassium Carbonate,三乙胺体系中,用 甲醇,乙醇,水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 8.33H,反应生成 7-氯-1-乙基-6-氟-4-氧氢喹啉-3-羧酸
参考文献:诺氟沙星化工合成方法
标题:诺氟沙星化工合成方法
摘要:本发明公开了一种诺氟沙星化工合成方法,如下步骤:(1),化合物喹啉酸乙酯的合成:将3‑乙胺基‑2‑(2,4‑二氯‑5‑氟苯甲酰基)丙烯酸乙酯溶解在dmf中,加入碳酸钾,之后加热到50‑80°C,反应过夜,冷却,倒入冰水中,将产生的固体过滤,固体用大量的水洗涤,得到产物喹啉酸乙酯;(2),化合物喹啉酸的合成:将喹啉酸乙酯溶解在甲醇中,加入1:1盐酸,回流2小时,有白色的固体析出,过滤,用水洗涤,真空烘箱烘干2小时,得到产物喹啉酸.本发明设计合理,选择一种新的合成诺氟沙星的方法,具有很好的市场应用价值.

专利信息

专利号:EP-1401829-B1
优先权日:2001-06-15
标题 :Novel heterocyclic antibacterial compounds
发明人：ZHI CHENGXIN; WRIGHT GEORGE E
权利人:MICROBIOTIX INC
摘要:The invention provides heterocyclic organic compounds that inhibit bacterial DNA polymerase IIIC and type II bacterial topoisomerase. The invention further provides compounds that are useful as intermediates in the synthesis of such heterocyclic organic compounds. Syntheses and uses of such heterocyclic organic molecules are also described.

专利号:US-6777420-B2
优先权日:2001-06-15
标题 :Heterocyclic antibacterial compounds
发明人：ZHI CHENGXIN; WRIGHT GEORGE E
权利人:MICROBIOTIX INC
摘要:The invention provides heterocyclic organic compounds that inhibit bacterial DNA polymerase IIIC and type II bacterial topoisomerase. The invention further provides compounds that are useful as intermediates in the synthesis of such heterocyclic organic compounds. Syntheses and uses of such heterocyclic organic molecules are also described.

专利号:RU-2014331-C1
优先权日:1986-10-15
标题:Method of synthesis of quinolinecarboxylic acid derivatives

专利号:US-10766863-B2
优先权日:2014-11-17
标 题 :Monocarboxylate transport modulators and uses thereof
发明人：SANDANAYAKA VINCENT; WU QIONG
权利人:NIROGYONE THERAPEUTICS INC
摘要:The invention generally relates to the field of monocarboxylate transport modulators, e.g., monocarboxylate transport inhibitors, and more particularly to new substituted-quinolone compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in treating, modulating, forestalling and/or reducing physiological conditions associated with monocarboxylate transport activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, obesity, diabetes, cardiovascular diseases, tissue and organ transplant rejection, and malaria.

专利号:CN-111320581-A
优先权日:2019-06-14
标题:Synthesis method of quinoline carboxylic ester

专利号:CN-115385856-A
优先权日:2022-09-05
标题:One-pot synthesis method of norfloxacin intermediate