CAS: 635-26-7; O-Tolylhydrazine Hydrochloride

上下游产品

o-toluidineo-toluidine 2-methylphenylhydrazineb]indole6-methyl-1,3,4,5-tetrahydro-thiopyrano[4,3-b]indole o-tolylhydrazone[1,3]thiazinan-2-one o-tolylhydrazone o-tolylthiosemicarbazide o-tolyl-1H-pyrazol-4-ylazo)-N-thiazol-2-yl-benzenesulfonamide4-(3,5-dimethyl-1-o-tolyl-1H-pyrazol-4-ylazo)-N-thiazol-2-yl-benzenesulfonamide

(2-甲基苯基)肼置于盐酸体系中,用39.5%的收率获得产物邻甲基苯肼盐酸盐
参考文献:一种2-甲基苯肼盐酸盐的制备方法
标题:一种2-甲基苯肼盐酸盐的制备方法
摘要:本发明涉及一种2‑甲基苯肼盐酸盐的制备方法,包括重氮化,还原,纯化,成盐的步骤.在重氮化和还原的步骤中,采用浓盐酸保持反应液呈强酸性,保证反应的顺利完全进行.在还原步骤中,采用锌粉‑浓盐酸作为还原剂,代替硫代硫酸钠,亚硫酸氢钠,氯化亚锡‑盐酸等,不但还原性能好,收率高,缩短反应时间,反应后反应生成的氢氧化锌等杂质便于去除,使产品杂质少,纯度高.在成盐步骤中用丙酮淋洗,既提高产品的纯度,又保证了产品的外观.本制备方法工艺稳定可靠,易于操作,产品纯度高(高效液相色谱测其含量>=99%),收率>=39%,完全满足市场对2‑甲基苯肼盐酸盐的需要.

专利信息

专利号:US-2024059701-A1
优先权日:2021-04-22
标 题 :Methods for Synthesis of an Advantageous N-Heterocyclic Carbene Catalyst
发明人：CAHANA AVIAD; FARONE WILLIAM A
权利人:XF TECH INC
摘要:The present invention concerns the synthesis of the salts of a Triazolium N-Heterocyclic Carbene (NHC) catalyst in various salt forms prepared from 2-methylaniline, 2-methylphenylhydrazine hydrochloride or 2-methylphenylhydrazine. The molecules so prepared are useful in catalysis of carbene reactions and are advantageous due to their lack of chlorinated or fluorinated intermediates and lack of chlorine or fluorine in the final structure.

专利号:US-12006337-B2
优先权日:2018-05-30
标题:Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof
发明人：HOLTZMAN MICHAEL J; ROMERO ARTHUR G; GEROVAC BENJAMIN J; HAN ZHENFU; KEELER SHAMUS P; WU KANGYUN; ZHANG YONG
权利人:WASHINGTON UNIVERSITY ST LOUIS
摘要:Compounds that inhibit mitogen-activated protein kinases (MAPKs) are disclosed. Some inhibitor compounds specifically target a single MAPK such as MAPK13, while others target multiple MAPKs such as MAPK13 and MAPK12. The compounds can be used therapeutically for a variety of diseases, including cancer and respiratory diseases. Methods of synthesis of the compounds are also disclosed.

专利号:WO-2022225825-A1
优先权日:2021-04-22
标题 :Methods for synthesis of an advantageous n-heterocyclic carbene catalyst

专利号:CA-3216413-A1
优先权日:2021-04-22
标 题 :Methods for synthesis of an advantageous n-heterocyclic carbene catalyst

专利号:AU-2022263339-A1
优先权日:2021-04-22
标题:Methods for synthesis of an advantageous n-heterocyclic carbene catalyst

专利号:CN-1219772-C
优先权日:2003-06-30
标题:Liquid Phase Synthesis of 1,3-Aryl Substituted Pyrazolines Containing Ester Groups at the 5-Position