CAS: 628-12-6; 2-Methoxyethyl Carbonochloridate

上下游产品

phosgene 2-methoxy-ethanol bis(trichloromethyl) carbonate 2-methoxyethyl carbamate bis-(2-methoxy-ethoxycarbonyl)-peroxide 7-(2-methoxy-ethoxycarbonylamino)-3-phenyl-coumarin N-Benzyl-N-benzyloxy-carbamidsaeure-(2-methoxy-ethylester)

📜光气,乙二醇甲醚 以 甲苯 作为反应溶剂,以50%的收率获得产物2-甲氧基氯甲酸乙酯
参考文献:基于聚乙二醇的烟碱乙酰胆碱受体同系配体.
标题:基于聚乙二醇的烟碱乙酰胆碱受体同系配体.
摘要:一系列同源聚乙二醇(peg)单甲醚与烟碱乙酰胆碱受体的三个配体系列缀合.制备了乙酰氨基胆碱,环状类似物 1-乙酰基-4,4-二甲基哌嗪鎓和吡啶基醚 A-84543 的缀合物.发现每个系列都对大鼠大脑皮层中的烟碱受体保持显着的亲和力,并具有多达六个 Peg 单元的系链.此类化合物是亲水性配体,可用作荧光/亲和探针和 Nachr 多价配体的模型.
DOI:10.1016/j.Bmc.2008.10.045

专利信息

专利号:WO-9700244-A1
优先权日:1995-06-19
标题 :Process for parallel synthesis of a non-peptide library
发明人：FRITZ JAMES E; KALDOR STEPHEN W
权利人:LILLY CO ELI; FRITZ JAMES E; KALDOR STEPHEN W
摘要:A process for the sequential preparation of a library of compounds having pharmaceutical usage. The process involves the sequential mixing of solution phase reagents, followed by scavenging of excess unreacted reagents with solid phase scavenging agents. The process is highly iterative and applicable for producing various ureas, thiureas, amides, carbonates and tertiary amines.

专利号:US-6632922-B1
优先权日:1998-03-19
标题 :Methods and compositions for controlled polypeptide synthesis
发明人：DEMING TIMOTHY J; CURTIN SCOTT A
权利人:UNIV CALIFORNIA
摘要:Methods and compositions for the generation of polypeptides having varied material properties are disclosed herein. Methods include means for making self assembling amphiphilic block copolypeptides and related protocols adding oligo(ethyleneglycol) functionalized aninoacid-N-carboxyanhydrides (NCAs) to polyaminoacid chains. Additional methods include means of adding an end group to the carboxy terminus of a polyaminoacid chain by reacting an alloc-protected amino acid amide with a transition metal-donor ligand complex, thereby forming an amido-amidate metallacycle for use in further polymerization reactions. Novel compositions for use in peptide synthesis and design including five and six membered amido-containing metallacycles and block copolypeptides are also disclosed.

专利号:EP-3070087-B1
优先权日:2011-08-05
标题 :Intermediates for the synthesis of cyclic p1 linkers as factor xia inhibitors

专利号:EP-3070087-A1
优先权日:2011-08-05
标 题 :Intermediates for the synthesis of cyclic p1 linkers as factor xia inhibitors

专利号:US-3998816-A
优先权日:1973-04-16
标题 :7-[5-N-(n-Butoxyethoxy carbonyl and 2-chloroethoxy carbonyl)-amino] cephalosporins C
发明人：SEKI SHIGEO; ISHIMARU TOSHIYASU
权利人:MEIJI SEIKA KAISHA
摘要:New and useful cephem compounds derived from cephalosporin C are provided by this invention, which are valuable as intermediate for the synthesis of another bacteriocidally active cephem derivatives and which are readily extractable from its aqueous solution by means of an organic solvent and enable the cephalosporin C content in the aqueous fermentation broth filtrate to be recovered at an improved yield. Cephalosporin C present in the fermentation broth may be converted into the cephem compounds of this invention by reacting with a substituted chloroformate compound within said filtrate, and the cephem compounds so formed may then be extracted therefrom with an organic solvent. The cephem compounds of this invention further may be converted into a 7-acylamidocephalosporanic acid or 7-aminocephalosporanic acid through some successive reactions.

专利号:US-7615634-B2
优先权日:2003-02-10
标题:4-aminopyrimidine-5-one derivatives
发明人：BARTKOVITZ DAVID JOSEPH; CHU XIN-JIE; DING QINGJIE; JIANG NAN; LOVEY ALLEN JOHN; MOLITERNI JOHN ANTHONY; MULLIN JR JOHN GUILFOYLE; VU BINH THANH; WOVKULICH PETER MICHAEL
权利人:HOFFMANN LA ROCHE
摘要:Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.