CAS: 61281-38-7; (6R,7S,12Ar)-5,6,7,8-Tetrahydro-1,2,3,10,11,12-Hexamethoxy-6,7-Dimethyldibenzo[a,C]Cyclooctene

该化合物是一种传统药用植物Schisandra Chinensis产生的生物活性离子体化合物,通过清除自由基和增强细胞防御机制,表现出显著的抗氧化特性.研究表明,它具有调节氧化压力相关途径的潜力,因此与...

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CAS号7432-28-2 五味子醇甲 | CAS号66280-25-9 戈米辛J

合成工艺路线路线简述

    📜(2R*,3S*)-2,3-Dimethly-1,4-Bis-(3,4,5-Trimethoxyphenyl)Butane 反应生成 五味子甲素
    参考文献:Kaseh,Iosio;Takehda,Sigehfumi;Ikehtani,Yukinobu;Aburada,Masaki;Taguti+
    标题:Kaseh,Iosio;Takehda,Sigehfumi;Ikehtani,Yukinobu;Aburada,Masaki;Taguti+

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    专利信息


    专利号:CN-1405142-A
    优先权日:2002-09-04
    标 题:Stereoselective and efficient synthesis of diphenylbutane lignans

    专利号:CN-101089231-A
    优先权日:2007-07-16
    标题:Electrolytic oxidation coupling of aryl-1,3-dicarbonyl compound and oxolane type high efficient PAF antagonist (anti)-2-5 II (3,4,5 trimethoxyphenyl) oxolane and synthesis method of its analogue

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Jia S, Guan H, Zhang S, Li Q. Schisandrin A Alleviates Inflammation and Oxidative Stress in Aβ25-35-Induced Alzheimer's Disease in Vitro Model. Actas Esp Psiquiatr. 2024 Oct;52(5):724-732. doi: 10.62641/aep.v52i5.1680.
    2: Sheng Y, Dong J, Wang R, Wang Y, Huang X, Chen C. The influence of storage conditions on the quality of Schisandra chinensis fruits: A integrated investigation of constituent and antioxidant activity. Heliyon. 2024 May 29;10(11):e32194. doi: 10.1016/j.heliyon.2024.e32194.
    3: Hu L, Zhang Z, Zhu F, Li X, Zou M, Yang R. Schizandrin A enhances the sensitivity of gastric cancer cells to 5-FU by promoting ferroptosis. Cytotechnology. 2024 Jun;76(3):329-340. doi: 10.1007/s10616-024-00623-4. Epub 2024 Mar 25.

    合成参考文献


    参考文献:10.2460/ajvr.2004.65.628
    摘要:Burgos RA, Hidalgo MA, Matthei SM, Hermosilla R, Folch H, Hancke JL. Determination of specific receptor sites for platelet activating factor in bovine neutrophils. Am J Vet Res. 2004 May;65(5):628–36. doi: 10.2460/ajvr.2004.65.628.
    参考文献:10.31083/ph.2014.3194
    摘要:Kong LM, Xu SY, Hu HH, Zhou H, Jiang HD, Yu LS, Zeng S. Identification of CYP2C19 inhibitors from phytochemicals using the recombinant human enzyme model. Pharmazie. 2014 May 01;69(5). doi: 10.31083/ph.2014.3194.
    参考文献:10.1080/10717544.2016.1225854
    摘要:Su X, Gao C, Shi F, Feng X, Liu L, Qu D, Wang C. A microemulsion co-loaded with Schizandrin A–docetaxel enhances esophageal carcinoma treatment through overcoming multidrug resistance. Drug Delivery. 2017 Jan 01;24(1):10–9. doi: 10.1080/10717544.2016.1225854.
    参考文献:10.1080/15376516.2022.2057263
    摘要:Deng Y, Zhang Z, Hong Y, Feng L, Su Y, Xu D. Schisandrin A alleviates mycophenolic acid-induced intestinal toxicity by regulating cell apoptosis and oxidative damage. Toxicology Mechanisms and Methods. 2022 Apr 07;32(8):580–7. doi: 10.1080/15376516.2022.2057263.
    参考文献:10.1271/bbb.90597
    摘要:OH S, KIM YH, BAE DS, UM BH, PAN C, KIM CY, LEE HJ, LEE JK. Anti-Inflammatory Effects of Gomisin N, Gomisin J, and Schisandrin C Isolated from the Fruit ofSchisandra chinensis. Bioscience, Biotechnology, and Biochemistry. 2010 Feb 23;74(2):285–91. doi: 10.1271/bbb.90597.
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