CAS: 5780-07-4; 7-Methoxybenzo[d][1,3]Dioxole-5-Carbaldehyde

上下游产品

methanol 5-hydroxyvanillin [1,3,5,7,2,6]tetroxadithi°Cane 2,2,6,6-tetraoxide 4-bromo-7-methoxybenzo[d][1,3]dioxole-5-carbaldehyde(E)-4-methoxy-6-(2-nitrovinyl)benzo[d][1,3]dioxole (E)-3-(7-methoxybenzo[d][1,3]dioxol-5-yl)acrylic acid 5-methoxy-3,4-methylenedioxybenzoic acid -2-nitropropene1-3-methoxy-4,5-(methylenedioxy)phenyl-2-nitropropene

📜5-溴香兰素置于铜,Potassium Carbonate,Copper(II) Oxide,Sodium Hydroxide体系中,用 水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 4.0H,反应生成 肉豆蔻醛
参考文献:设计,合成和评估新型他克林-多烷氧基苯杂化物作为胆碱酯酶和淀粉样β聚集的双重抑制剂
标题:设计,合成和评估新型他克林-多烷氧基苯杂化物作为胆碱酯酶和淀粉样β聚集的双重抑制剂
摘要:一系列新的他克林-Multialkoxybenzene杂种(的图9A-9N)设计,合成和评价为胆碱酯酶(胆碱酯酶)和自诱导β的双重抑制剂-淀粉样蛋白(aβ)聚集.所有合成的化合物均具有较高的乙酰胆碱酯酶(ache)和丁酰胆碱酯酶(buche)抑制活性,Ic 50值在纳摩尔范围内,比单独使用他克林要好得多.lineweaver-Burk图和分子建模研究表明,这些杂种同时针对ache的催化活性位点(cas)和外围阴离子位点(pas).此外,化合物9A-9F具有亚甲二氧基苯部分的化合物显示出比参考化合物姜黄素更高的自我诱导的aβ聚集抑制活性.这些化合物可以被选作多效药物,以进一步研究治疗ad.
DOI:10.1016/j.Bmc.2010.12.022

专利信息

专利号:WO-2009026961-A1
优先权日:2007-08-30
标 题:Processes for the preparation of pancratistatin and pancratistatin analogues
发明人：ALONSO ALONSO RICARDO; OZORES VITURRO LIDIA; CAGIDE FAGIN FERNANDO; ORTIZ LARA JUAN CARLOS
权利人:UNIV SANTIAGO COMPOSTELA; ALONSO ALONSO RICARDO; OZORES VITURRO LIDIA; CAGIDE FAGIN FERNANDO; ORTIZ LARA JUAN CARLOS
摘要:Processes for the preparation of pancratistatin and pancratistatin analogues. The key step is the reaction of a 1,3-dioxan-5-one and a nitroolefine in the presence of an amine. The process may take place in an enantioselective way when a chiral amine is used. Reduction processes then give new and advanced intermediates that are useful for the preparation of pancratistatin or selected pancratistatin analogues. The reported process also provides a method for the efficient synthesis of nitroenals, starting materials of the synthesis. Analogues of pancratistatin are also provided.

专利号:US-5569786-A
优先权日:1987-01-06
标 题 :Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated 'combretastatins'
发明人：PETTIT GEORGE R; SINGH SHEO B
权利人:UNIV ARIZONA
摘要:New antineoplastic substances have been isolated, structurally elucidated and synthesized having a general structural formula of: (I) or H or OCH3; or R1R2 is -OCH2O-; R3 is H or OH; and R4 is OH or OCH3. These substances have been denominated 'combretastatin A-1, -A-2, -A-3, -B-1, -B-2, -B-3 and -B-4'. preparation containing the substances and methods of treating a host inflicted with a neoplastic growth with the preparation is described.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:US-5409953-A
优先权日:1987-01-06
标题:Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated 'combretastatins'

专利号:US-2006160773-A1
优先权日:2003-07-18
标 题 :Combretastatin derivatives with cytotoxic action
发明人：GIANNINI GIUSEPPE; PISANO CLAUDIO; ALLOATTI DOMENICO; ROMAGNOLI ROMEO; SIMONI DANIELE
权利人:GIANNINI GIUSEPPE; PISANO CLAUDIO; ALLOATTI DOMENICO; ROMAGNOLI ROMEO; SIMONI DANIELE
摘要:The invention described herein relates to new combretastatin derivatives obtained by total synthesis and having the following general formula: n nin which the groups are as defined in the description here below. Said compounds, though chemically related to the structure of cis/trans-combretastatin, do not always bind tubulin, but nevertheless exhibit cytotoxic activity of interest in the oncological field as anticancer and/or antiangiogenic agents.