CAS: 56558-18-0; 2,3',4,5',6-Pentachlorobiphenyl

化学文摘社编号56558-18-0,PCB 121的特点是其双联体结构,其中两个苯环由一个单一的联结连接,并含有与环相连的多种氯原子.具体地说,PCB 121共有五个氯原子,这对其化学特性,包括其疏水性和稳定性有重大影响.该化合物一般不色,对轻黄色无色,因其高热稳定性和易降解性而闻名,因此在电气设备和热传输液等各种工业应用中有用.然而,多氯联苯,包括PCB 121在内,因其环境持久性和潜在的健康风险,包括致癌效应和内分泌干扰,因此在许多国家都基本禁止或限制多氯联苯的生产和使用.

英文名称2,3',4,5',6-Pentachlorobiphenyl
中文名称2,3',4,5',6-五氯联苯
IUPAC名称1,3,5-trichloro-2-(3,5-dichlorophenyl)benzene
其它别名2,3',4,5',6-Pentachlorobiphenyl; 2,4,6,3',5'-Pentachlorobiphenyl
CAS编号56558-18-0
FDA UNII编号:2R99YR2114
分子式:C12H5Cl5分子量:326.437
产品CID: 1539130
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
产品信息参考;;;;
InChIKey: XBVSGJGMWSKAKL-UHFFFAOYSA-N
1S/C12H5Cl5/c13-7-1-6(2-8(14)3-7)12-10(16)4-9(15)5-11(12)17/h1-5H
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

1,3,5-trichloro-2-iodobenzene 3,5-dichloroiodobenzene 1,3,6,8-tetrachlorodibenzofuran

合成工艺路线路线简述

📜1-碘-2,4,6-三氯苯,3,5-二氯碘苯置于铜体系中,用 N,N-二甲基甲酰胺作为反应溶剂,化学反应生成 2,3',4,5',6-五氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4