CAS: 5317-32-8; 3-(Piperazin-1-yl)Propan-1-Ol

该化合物是一种有机化合物,其特点是其管状素和丙醇功能组,其结构一般看起来无色可粉黄液,由于存在增加其极度的氢氧基(-OH)和安咪(-NH)组,在水中可溶解;该化合物显示出基本特性,主要由于可参与氢联结和质变反应的管子环. 1-Piperazinepropanol经常用于制药用途,特别是作为各种生物活性化合物合成的中间体,其结构允许与生物系统进行潜在互动,使其对药用化学感兴趣.此外,它可能表现出中度毒性,需要在使用期间谨慎地处理和安全防范.

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132710-90-8 88708-40-1 82972-28-9

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上下游产品

CAS号7483-27-4 4-(3-羟基丙基)-1-哌嗪羧酸乙酯 | CAS号110-85-0 哌嗪 | CAS号627-18-9 3-溴-1-丙醇 | CAS号627-30-5 3-氯-1-丙醇 | CAS号7755-92-2 N-甲酰基哌嗪 | CAS号627-32-7 3-碘-1-丙醇 | CAS号107-18-6 烯丙醇 | CAS号13173-24-5 Piperazine,1,4-... | CAS号104664-37-1 3-[4-[(E)-2-(1-... | CAS号30297-78-0 1-Piperazinepro... | CAS号88708-40-1 1-(3-甲氧基丙基)哌嗪 | CAS号5317-33-9 1-(3-羟丙基)-4-甲基哌嗪 | CAS号132710-90-8 1-叔丁氧羰基-4-(3-羟基丙烷)哌嗪 | CAS号112764-15-5 N-(9,10-dioxoan... | CAS号74667-82-6 1-Piperazinepro... | CAS号74667-83-7 3-[4-(3-methyls...

合成工艺路线路线简述

    📜4-(3-羟基丙基)-1-哌嗪羧酸乙酯置于水,Sodium Hydroxide体系中,用 乙醇 作为反应溶剂,化学反应生成 1-哌嗪基丙醇
    参考文献:Pharmacophore-Based Design,Synthesis,And Biological Evaluation Of Novel Chloro-Pyridazine Piperazines As Human Rhinovirus (Hrv-3) Inhibitors
    标题:Pharmacophore-Based Design,Synthesis,And Biological Evaluation Of Novel Chloro-Pyridazine Piperazines As Human Rhinovirus (Hrv-3) Inhibitors
    摘要:A Series Of Chloro-Pyridazine Piperazines Were Developed Based On The Structure Of Human Rhinovirus (Hrv) Capsid-Binding Inhibitors With Proven Activity Using A Pharmacophore Model. A Preliminary Evaluation Demonstrated Potent Activity Against Hrv-3 With Low Cytotoxicity. A Docking Analysis Indicated That 8A Could Fit Into,And Form Tight Interactions (E. G.,H-Bonds,Sigma-Pi Effect) With The Active Site In Vp1. (C) 2010 Elsevier Ltd. All Rights Reserved.
    DOI:10.1016/j.Bmcl.2010.12.001

    海关参考信息

    专利信息


    专利号:US-4092316-A
    优先权日:1975-02-03
    标题:Synthesis of C-alkyl-triethylenediamines
    发明人:NIEH EDWARD C Y
    权利人:TEXACO DEVELOPMENT CORP
    摘要:A liquid phase synthesis of C-alkyl-triethylenediamines involves heating to elevated temperatures of from about 200° C to 300° C a suitable N-(2-hydroxyalkyl) piperazine feedstock in the presence of a catalytic amount of a pentavalent acidic phosphorus compound and then recovering the C-alkyl-triethylenediamine product from the resulting reaction product mixture.

    专利号:WO-2014059961-A1
    优先权日:2012-10-15
    标 题 :Method for the synchronous absorption of carbon dioxide from flue gas and synthesis of dialkyl carbonates and alkylene carbonates
    发明人:BÜTTNER HERMANN; Müller Jürgen; JONKER RAPHAEL; DOEDT SEBASTIAN; BOSSE TOBIAS; MAKRAN SEBASTIAN
    权利人:BÜTTNER HERMANN
    摘要:The invention relates to a synchronous CCU method (carbon dioxide capture and utilisation) for the absorption of carbon dioxide from flue gas and other CO 2 -containing substance sources and simultaneous synthesis of dialkyl carbonates and alkylene carbonates. The general subject matter of the invention is, in terms of a 'carbon dioxide capture' on the one hand, the absorption of CO 2 from flue gas and other CO 2 -containing substance sources with ammonia and/or amines to form ammonium carbamates or ammonium hydrogen carbonates or ureas or urea intermediates and, in terms of a 'carbon dioxide utilisation' on the other hand, the reaction of ammonium carbamates or ammonium hydrogen carbonates or ureas or urea intermediates with aliphatic, alicyclic or unsaturated alcohols, and including unsaturated aromatic alcohols to give dialkyl carbonates or alkylene carbonates in such a form that the CO 2 n absorption agent is re-released and fed back into the repetitive process again. A repetitive process control is extremely energy and CO 2 n efficient.

    专利号:US-4678784-A
    优先权日:1984-04-11
    标题 :Method for the treatment of LHRH diseases and conditions
    发明人:HO CHIH Y
    权利人:MCNEILAB INC
    摘要:Fused tetracyclic benzodiazepines of the formula (I): (I) where R1 is a cyclic amine such as 1-piperazine and R2 is H or a substituent as defined herein are useful as LHRH antagonizing agents. Also, methods for their synthesis, intermediates used in such synthesis, methods for use as medicaments and pharmaceutical compositions are described.

    专利号:US-6177087-B1
    优先权日:1994-06-24
    标 题:Non-antigenic amine derived polymers and polymer conjugates
    发明人:GREENWALD RICHARD B; MARTINEZ ANTHONY; PENDRI ANNAPURNA
    权利人:ENZON INC
    摘要:Substantially non-antigenic polymers containing pI and/or pH optimum modulating moieties are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleophiles. Conjugates and methods of preparation and treatment with the conjugates are also disclosed.

    专利号:US-3342820-A
    优先权日:1964-08-31
    标 题 :Synthesis of c-alkyl-triethylenediamine
    发明人:BRADER JR WALTER H
    权利人:JEFFERSON CHEM CO INC

    专利号:DE-102012020141-A1
    优先权日:2012-10-15
    标题:Process for the synchronous absorption of carbon dioxide from flue gas and synthesis of dialkyl carbonates and alkylene carbonates

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Osadebe PO. Structure-activity relationship studies: study of the analgesic properties of a series of synthesized esters of 3- (4-benzyl-1-piperazinyl) 1-phenylpropanols. Boll Chim Farm. 2004 Apr;143(3):116–9.
    摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
    摘要:Schwan, A. L., Science of Synthesis, (2004) 17, 734.
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