📜4-(3-羟基丙基)-1-哌嗪羧酸乙酯置于水,Sodium Hydroxide体系中,用 乙醇 作为反应溶剂,化学反应生成 1-哌嗪基丙醇 参考文献:Pharmacophore-Based Design,Synthesis,And Biological Evaluation Of Novel Chloro-Pyridazine Piperazines As Human Rhinovirus (Hrv-3) Inhibitors 标题:Pharmacophore-Based Design,Synthesis,And Biological Evaluation Of Novel Chloro-Pyridazine Piperazines As Human Rhinovirus (Hrv-3) Inhibitors 摘要:A Series Of Chloro-Pyridazine Piperazines Were Developed Based On The Structure Of Human Rhinovirus (Hrv) Capsid-Binding Inhibitors With Proven Activity Using A Pharmacophore Model. A Preliminary Evaluation Demonstrated Potent Activity Against Hrv-3 With Low Cytotoxicity. A Docking Analysis Indicated That 8A Could Fit Into,And Form Tight Interactions (E. G.,H-Bonds,Sigma-Pi Effect) With The Active Site In Vp1. (C) 2010 Elsevier Ltd. All Rights Reserved. DOI:10.1016/j.Bmcl.2010.12.001
专利号:US-4092316-A 优先权日:1975-02-03 标题:Synthesis of C-alkyl-triethylenediamines 发明人:NIEH EDWARD C Y 权利人:TEXACO DEVELOPMENT CORP 摘要:A liquid phase synthesis of C-alkyl-triethylenediamines involves heating to elevated temperatures of from about 200° C to 300° C a suitable N-(2-hydroxyalkyl) piperazine feedstock in the presence of a catalytic amount of a pentavalent acidic phosphorus compound and then recovering the C-alkyl-triethylenediamine product from the resulting reaction product mixture.
专利号:WO-2014059961-A1 优先权日:2012-10-15 标 题 :Method for the synchronous absorption of carbon dioxide from flue gas and synthesis of dialkyl carbonates and alkylene carbonates 发明人:BÜTTNER HERMANN; Müller Jürgen; JONKER RAPHAEL; DOEDT SEBASTIAN; BOSSE TOBIAS; MAKRAN SEBASTIAN 权利人:BÜTTNER HERMANN 摘要:The invention relates to a synchronous CCU method (carbon dioxide capture and utilisation) for the absorption of carbon dioxide from flue gas and other CO 2 -containing substance sources and simultaneous synthesis of dialkyl carbonates and alkylene carbonates. The general subject matter of the invention is, in terms of a 'carbon dioxide capture' on the one hand, the absorption of CO 2 from flue gas and other CO 2 -containing substance sources with ammonia and/or amines to form ammonium carbamates or ammonium hydrogen carbonates or ureas or urea intermediates and, in terms of a 'carbon dioxide utilisation' on the other hand, the reaction of ammonium carbamates or ammonium hydrogen carbonates or ureas or urea intermediates with aliphatic, alicyclic or unsaturated alcohols, and including unsaturated aromatic alcohols to give dialkyl carbonates or alkylene carbonates in such a form that the CO 2 n absorption agent is re-released and fed back into the repetitive process again. A repetitive process control is extremely energy and CO 2 n efficient.
专利号:US-4678784-A 优先权日:1984-04-11 标题 :Method for the treatment of LHRH diseases and conditions 发明人:HO CHIH Y 权利人:MCNEILAB INC 摘要:Fused tetracyclic benzodiazepines of the formula (I): (I) where R1 is a cyclic amine such as 1-piperazine and R2 is H or a substituent as defined herein are useful as LHRH antagonizing agents. Also, methods for their synthesis, intermediates used in such synthesis, methods for use as medicaments and pharmaceutical compositions are described.
专利号:US-6177087-B1 优先权日:1994-06-24 标 题:Non-antigenic amine derived polymers and polymer conjugates 发明人:GREENWALD RICHARD B; MARTINEZ ANTHONY; PENDRI ANNAPURNA 权利人:ENZON INC 摘要:Substantially non-antigenic polymers containing pI and/or pH optimum modulating moieties are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleophiles. Conjugates and methods of preparation and treatment with the conjugates are also disclosed.
专利号:US-3342820-A 优先权日:1964-08-31 标 题 :Synthesis of c-alkyl-triethylenediamine 发明人:BRADER JR WALTER H 权利人:JEFFERSON CHEM CO INC
专利号:DE-102012020141-A1 优先权日:2012-10-15 标题:Process for the synchronous absorption of carbon dioxide from flue gas and synthesis of dialkyl carbonates and alkylene carbonates
摘要:Osadebe PO. Structure-activity relationship studies: study of the analgesic properties of a series of synthesized esters of 3- (4-benzyl-1-piperazinyl) 1-phenylpropanols. Boll Chim Farm. 2004 Apr;143(3):116–9. 摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003). 摘要:Schwan, A. L., Science of Synthesis, (2004) 17, 734.