CAS: 40018-25-5; 2-Chlorobenzoylacetonitrile

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CAS号609-65-4 邻氯苯甲酰氯 | CAS号372-09-8 氰基乙酸 | CAS号610-96-8 邻氯苯甲酸甲酯 | CAS号75-05-8 乙腈 | CAS号17849-38-6 2-氯苄醇 | CAS号35022-42-5 2-氯苯甲酰腈 | CAS号590-17-0 溴乙腈 | CAS号873-32-5 邻氯苯腈 | CAS号55330-47-7 β-amino-2-chlor... | CAS号143-33-9 氰化钠 | CAS号50508-60-6 2-氨基-3-(2-氯苯甲酰)... | CAS号40017-58-1 (2-氨基噻吩-3-基)(2-... | CAS号29462-26-8 (2-氨基-4,5,6,7-四... | CAS号27025-73-6 3-(2-氯苯基)-5(4H)-异噁唑酮 | CAS号27025-74-7 3-(2-氯苯基)-5-氨基异噁唑 | CAS号130534-59-7 tert-butyl N-[3... | CAS号100827-77-8 2-Amino-3-(2-ch... | CAS号100827-80-3 7-(2-Carbometho... | CAS号100827-79-0 2-Bromoacetylam... | CAS号100827-83-6 4-(2-Chlorophen...

β-Amino-2-Chloro-Cinnamonitrile置于盐酸体系中,用 氯仿 作为反应溶剂,化学反应生成 邻氯苯乙酰腈
参考文献:潜在的抗关节炎药.2.苯甲酰基乙腈和β-氨基肉桂腈.
标题:潜在的抗关节炎药.2.苯甲酰基乙腈和β-氨基肉桂腈.
摘要:在大鼠佐剂性关节炎模型中,苯甲酰乙腈和β-氨基肉桂腈显示出有效的抗炎活性.在一系列苯基取代的类似物中,仅邻,间和对氟苯甲酰基乙腈以及间和对氟β-氨基肉桂腈保留了活性.另外,β-氨基-2-和β-氨基-3-噻吩丙烯腈以及β-氧代-2-和β-氧代-3-噻吩丙腈表现出相似的活性.不认为这些试剂通过前列腺素合成酶抑制起作用.还描述了苯甲酰基乙腈的代谢特征.
DOI:10.1021/jm00197A020

专利信息

专利号:RU-2072991-C1
优先权日:1991-10-09
标题:3-phenylpyrazole derivatives, method of synthesis of 3-phenylpyrazole derivatives and fungicide composition

专利号:US-6987105-B2
优先权日:2000-04-28
标题 :Synthesis and use of thienotriazolodiazepines
发明人：BAZAN NICOLAS G; GOMEZ JULIO ALVAREZ BUILLA
权利人:UNIV LOUISIANA STATE
摘要:A new method to synthesize the platelet-activating factor antagonist which is a derivative of thienotriazolodiazepene, tetrahydro-4,7,8,10 methyl-1(chloro-2 phenyl)-6 (methosy-4 phenyl carbamoyl)-9 pyrido[4,3-:4,5] thieno[3,2-f] triazolo-1,2,4 [4,3-α] diazepine-1,4] (1) is disclosed. The compound synethesized by this new method has been designated “LAU-8080â€? which has the same structure as the compound currently named in the literature as “BN-50730.â€? LAU-8080 was shown to prevent photoreceptor cell death, inhibit pathological neovascularization in the retina, and minimize the loss of neurons due to ischemic-reperfusion damage due to stroke. Thus LAU-8080 can be used to treat the retinal diseases of age-related macular degeneration, retinitis pigmentosa, and diabetic retinopathy. It can also be used to minimize the neuronal damage due to stroke.

专利号:EP-0388789-A1
优先权日:1989-03-18
标 题 :Process for the production of enantiomers of hetrazepines
发明人：STRANSKY WERNER DR; LANGBEIN ADOLF DR; BRANDT KLAUS DR; WEBER KARL-HEINZ DR; WALTHER GERHARD DR
权利人:BOEHRINGER INGELHEIM KG; BOEHRINGER INGELHEIM INT
摘要:The invention relates to an improved process for the preparation of enantiomerically pure hetrazepines by a stereospecific synthesis starting from cyclopentane-3-carboxylic acid esters.

专利号:US-2003229078-A1
优先权日:2000-04-28
标 题:Synthesis and use of thienotriazolodiazepines

专利号:SU-1738089-A3
优先权日:1986-07-22
标 题 :Method of hetrazepine derivatives synthesis

专利号:CN-103739588-A
优先权日:2014-01-04
标 题 :A Simple Synthesis Method of 2-Aminothiophene Derivatives