CAS: 3403-25-6; H-D-Phe-Otbu.Hcl

相似化合物

75898-47-4 15100-75-1 16874-17-2

上下游产品

CAS号673-06-3 D-苯丙氨酸 | CAS号115-11-7 2-甲基丙烯

📜D-苯丙氨酸,异丁烯置于硫酸体系中,用 1,4-二氧六环 作为反应溶剂,以77%的收率获得产物d-苯丙氨酸叔丁酯盐酸盐
参考文献:氨基酸和肽的研究x:HPLC介导的2,4-双(4-甲氧基苯基)-1,3,2,4-二硫代二磷-苯丙氨酸2,4-二硫化物(劳氏试剂)的无消旋偶联试剂
标题:氨基酸和肽的研究x:HPLC介导的2,4-双(4-甲氧基苯基)-1,3,2,4-二硫代二磷-苯丙氨酸2,4-二硫化物(劳氏试剂)的无消旋偶联试剂
摘要:已经测试了易于获得的2,4-双(4-甲氧基苯基)-1,3,2,4-二硫代二膦2,4-二硫化物(lawesson'S Reagent)1作为肽合成中外消旋的偶联剂.测定步骤是通过HPLC分离立体异构产物.zs-Pro-S-Val-S-Pro-Otbu和zs-Leu-S-Phe-S-Val-Otbu被用作2 + 1段偶联的测试肽,并且只有少量差向异构(0.5和分别观测到<0.1%).
DOI:10.1016/s0040-4020(01)91366-3

专利信息

专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

专利号:WO-2022265577-A2
优先权日:2021-06-15
标题:Coronavirus enzyme modulators, methods of synthesis and uses thereof