CAS: 25597-16-4; Ethyl (E)-4,4,4-Trifluorobut-2-Enoate

相似化合物

71027-02-6 674-53-3 83706-94-9

上下游产品

CAS号372-30-5 4,4,4-三氟-3-羟基丁酸乙酯 | CAS号372-31-6 三氟乙酰乙酸乙酯 | CAS号867-13-0 磷酰基乙酸三乙酯 | CAS号75-90-1 三氟乙醛 | CAS号64-17-5 乙醇 | CAS号406-94-0 (E)-4,4,4-三氟丁-2-烯酸 | CAS号105-53-3 丙二酸二乙酯 | CAS号406-93-9 4,4,4-三氟丁酸 | CAS号371-26-6 4,4,4-三氟丁酸乙酯 | CAS号461-18-7 4,4,4-三氟丁醇 | CAS号215123-85-6 6-氯-2-(三氟甲基)-2H... | CAS号590-76-1 4,4,4-三氟巴豆酰胺 | CAS号120732-04-9 4-三氟甲基-1H-吡咯-3-羧酸乙酯 | CAS号328-62-1 ethyl 4,4,4-tri... | CAS号138852-02-5 diethyl 3-(trif... | CAS号124612-15-3 5-(trifluoromet... | CAS号372-27-0 Ethyl 3-bromo-4...

3-羟基-4,4,4-三氟丁酸乙酯置于磷酸酐体系中,化学反应 1.0H,以69%的收率获得4,4,4-三氟巴豆酸乙酯
参考文献:由氟乙酸酯三步制备丙烯酸β-氟代烷基酯的研究
标题:由氟乙酸酯三步制备丙烯酸β-氟代烷基酯的研究
摘要:β-氟烷基丙烯酸酯是有机氟化合物合成的重要组成部分.尽管已知几种β-氟代烷基丙烯酸酯的制备方法,但尚无用于从氟代乙酸酯制备数克这些化合物的通用且直接的实验室规模方法,并且尚未对相关化学方法进行详细研究.现在,我们基于以下内容描述一种优化的三步协议:(1)使用lda作为碱,将氟乙酸酯与乙酸乙酯进行claisen型缩合;(2)以甲苯或苯用作溶剂,用nabh 4还原所得的γ-氟-β-酮酯.(3)p 2 O 5促进中间体γ-氟-β-羟基酯的脱水.该方法可提供仅包含氟原子(cf 3,Chf 2,C 2 F 5)的目标化合物的制备有用的收率,而无法以分析纯的形式获得γ-卤代二氟甲基(cclf 2,Cbrf 2,Cif 2)丙烯酸酯从脱水步骤中形成.
Doi:10.1016/j.Tet.2006.12.045

专利信息

专利号:WO-2006040676-A1
优先权日:2004-10-12
标题 :Nitrosated benzopyran compounds as novel cyclooxygenase-2 selective inhibitors
发明人：TJOENG FOE SIONG; CARTER JEFFERY; SPRINGER JOHN ROBERT; ZUPEC MARK E
权利人:PHARMACIA & UPJOHN CO LLC; TJOENG FOE SIONG; CARTER JEFFERY; SPRINGER JOHN ROBERT; ZUPEC MARK E
摘要:This invention specifically relates to novel cyclooxygenase 2 (COX-2) selective inhibitor compounds that donate, transfer or release nitric oxide, stimulate endogenous synthesis of nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase. Compounds of particular interest and their analogs defined by formula (I) wherein Z, X, R1, R2, R3, and R4 are as described in the specification. This invention also relates to pharmaceutical compositions and methods for treating COX-2 mediated disorders, such as inflammation and inflammation related disorders.

专利号:US-10414744-B2
优先权日:2016-03-09
标 题 :4-sulfur pentafluoride phenol compound and preparation method therefor, and preparation method for sulfur pentafluoride substituted benzopyran compound
发明人：ZHANG YANMEI; TALLEY JOHN J; WANG YICAN; HE CHUANG; GUAN JIANTONG; LIN YONGJIE; TORTORELLA MICKY D
权利人:GUANGZHOU INST BIOMED & HEALTH
摘要:Provided are a 4-sulfur pentafluoride phenol compound and a preparation method therefor, and a preparation method for a sulfur pentafluoride substituted benzopyran compound. According to the present invention, sulfur pentafluoride salicylaldehyde with multiple substituent groups is synthesized through a plurality of steps by using sulfur pentafluoride phenol as a raw material, and then the sulfur pentafluoride substituted benzopyran compound is synthesized on this basis. The method is simple and convenient, and low in cost; overcomes the defects that, at present, the number of types of sulfur pentafluoride phenols is small, and the synthesis of various sulfur pentafluoride substituted benzopyran compounds cannot be met; and has wide industrial application prospects.

专利号:ES-2715563-T3
优先权日:2011-09-21
标题:Method to control the formation of undesirable by-products caused by polluting organisms in the production of ethanol from synthesis gas

专利号:US-4645838-A
优先权日:1982-05-12
标题 :Pyrazolopyridine compounds, and intermediates, useful as anxiolytic agents
发明人：BARE THOMAS M; HEALD ANTHONY F
权利人:ICI AMERICA INC
摘要:Compounds of the formula (I): ##STR1## wherein R 1 , R 3 , R 4 , R 7 and R 8 are as described herein, D is oxygen, n is 1 or 2 and the physiologically acceptable salts thereof useful in reducing anxiety in an animal such as man. The compounds are potent anxiolytics having reduced side effects compared to known anxiolytics. Also pharmaceutical compositions, intermediates and methods of treatment and synthesis are described.