CAS: 249647-24-3; Methyl 3-Bromo-4-Iodobenzoate

上下游产品

3-溴-4-碘苯甲酸 3-Bromo-4-Iodobenzoic Acid 249647-25-4
4-碘苯甲酸甲酯 Methyl 4-Iodobenzoate 619-44-3
4-氨基-3-溴苯甲酸甲酯 Methyl 4-Amino-3-Bromobenzoate 106896-49-5
4-氨基-3-溴苯甲酸 4-Amino-3-Bromo-Benzoic Acid 6311-37-1

📜4-碘苯甲酸甲酯置于n-溴代丁二酰亚胺(Nbs),硫酸体系中,化学反应 15.0H,以99%的收率获得3-溴-4-碘苯甲酸甲基酯
参考文献:Discovery Of Potent And Selective Sh2 Inhibitors Of The Tyrosine Kinase Zap-70
标题:Discovery Of Potent And Selective Sh2 Inhibitors Of The Tyrosine Kinase Zap-70
摘要:A Series Of 1,2,4-Oxadiazole Analogues Has Been Shown To Be Potent And Selective Sh2 Inhibitors Of The Tyrosine Kinase Zap-70,A Potential Therapeutic Target For Immune Suppression. These Compounds Typically Are 200-400-Fold More Potent Than The Native,Monophosphorylated Tetrapeptide Sequences. When Compared With The High-Affinity Xi-1-Itam Peptide (Ac-Nql-Pynelnlgrree-Pydvld-Nh2,Wherein Py Refers To Phosphotyrosine) Some Of The Best 1,2,4-Oxadiazole Analogues Are Approximately 1 Order Of Magnitude Less Active. This Series Of Compounds Displays An Unprecedented Level Of Selectivity Over The Closely Related Tyrosine Kinase Syk,As Well As Other Sh2-Containing Proteins Such As Src And Grb2. Gel Shift Studies Using A Protein Construct Consisting Only Of C-Terminal Zap-70 Sh2 Demonstrate That These Compounds Can Effectively Engage This Particular Sh2 Domain.
Doi:10.1021/jm990229T

专利信息

专利号:CN-105669590-A
优先权日:2016-03-08
标 题 :Catalyst-free synthesis of phenothiazine drug intermediates