CAS: 2361-96-8; N-Acetyl-L-Phenylalanine Ethyl Ester

该化合物是一种经过修改的氨基酸衍生物,结合了L-苯麻ine与乙酰和乙酯功能组的结构特征,该化合物主要用于合成和药物研究,因为与母氨基酸相比,该化合物在有机溶剂中的稳定性和溶性有所提高,而且与母氨基酸相比,该化合物的稳定性和溶性得到改善.乙酰基组保护了地雷的功能,而乙酯则对碳酸酯组进行了修改,促进了固相聚中的碳化物反应.其阳性纯度和与标准保护组战略的兼容性使该化合物成为建造复杂的浸泡剂和生物活性分子的有价值的中间体.该化合物的特征通常是HPLC和NMR,以确保高化学和抗蛋白性纯度.

结构式图片

相似化合物

10172-89-1 2018-61-3 2901-75-9

上下游产品

CAS号2018-61-3 N-乙酰-L-苯丙氨酸 | CAS号75-03-6 碘乙烷 | CAS号64-17-5 乙醇 | CAS号108395-58-0 acetyl L-phenyl... | CAS号38453-16-6 (S)-4-(2-acetam... | CAS号64-19-7 冰醋酸 | CAS号62436-67-3 ethyl (Z)-2-ace... | CAS号51439-57-7 ethyl 2-acetami... | CAS号18934-57-1 L-Phenylalanine... | CAS号3618-96-0 N-乙酰基-L-苯丙氨酸甲酯 | CAS号840-97-1 N-乙酰-L-酪氨酸乙酯 | CAS号10030-31-6 Ac-Phe-Phe-OH | CAS号229180-64-7 Fm°C-4-(膦酰基甲基)-... | CAS号2018-61-3 N-乙酰-L-苯丙氨酸 | CAS号29701-43-7 N-Ac-Phe-Gly-NH2 | CAS号64-17-5 乙醇 | CAS号142434-81-9 3-磷甲基-L-苯丙氨酸

合成工艺路线路线简述

    📜N-乙酰-L-苯丙氨酸置于盐酸体系中,化学反应生成N-乙酰-L-苯丙氨酸乙酯
    参考文献:Smith; Spackman,Journal Of Biological Chemistry,1955,Vol. 212,P. 271,291
    标题:Smith; Spackman,Journal Of Biological Chemistry,1955,Vol. 212,P. 271,291

    海关参考信息

    专利信息


    专利号:US-2005027102-A1
    优先权日:1992-12-28
    标题 :Use of molecularly imprinted polymers for stereo- and/or regioselective synthesis
    发明人:MOSBACH KLAUS; NICHOLLS IAN A; RAMSTROM OLOF
    摘要:Molecularly imprinted polymers can be utilized in stereo- and regio-selective synthesis. These systems can be utilized, e.g. for peptide synthesis, by selectively coordinating reactants at a predetermined preformed cavity. Further, such polymers may be used for the selective removal of one enantiomeric species from solution, allowing reaction to be directed to another species in bulk solution leading to stereoselective and/or regio-selective synthesis in the cavity of for instance peptides. Additionally, when utilized as regioselectively interacting protectioning matrices, these polymers can direct reaction to an alternate centre of a reacting substrate.

    专利号:EP-0675898-B1
    优先权日:1992-12-28
    标题 :Use of molecularly imprinted polymers for stereo- and/or regioselective synthesis
    发明人:MOSBACH KLAUS; NICHOLLS IAN A; RAMSTROEM OLOF
    权利人:MOSBACH KLAUS H
    摘要:Molecularly imprinted polymers can be utilized in stereo- and regio-selective synthesis. These systems can be utilized, e.g. for peptide synthesis, by selectively coordinating reactants at a predetermined preformed cavity. Further, such polymers may be used for the selective removal of one enantiomeric species from solution, allowing reaction to be directed to another species in bulk solution leading to stereoselective and/or regioselective synthesis in the cavity of for instance peptides. Additionally, when utilized as regioselectively interacting protectioning matrices, these polymers can direct reaction to an alternate centre of a reacting substrate.

    专利号:US-2005032187-A1
    优先权日:2003-08-01
    标题:Novel peptide-forming enzyme, microbe producing the enzyme and method for producing peptide using them
    发明人:YOKOZEKI KENZO; SUZUKI SONOKO; HARA SEIICHI; KATAYAMA SATOSHI
    权利人:AJINOMOTO KK
    摘要:The present invention relates to a novel enzyme that allows peptide to be produced easily, inexpensively and at high yield without going through a complex synthesis method. More particularly, the present invention provides a novel enzyme that catalyzes a peptide-producing reaction from a carboxy component and an amine component, a microbe that produces the enzyme, and a method for inexpensive production of peptides using this enzyme or microbe. The novel enzyme that efficiently produces peptide was discovered from a newly discovered microbe belonging to the genus Empedobacter , and a method was found that allows peptides to be produced inexpensively and easily.

    专利号:US-2005032154-A1
    优先权日:2002-07-26
    标题 :Method for producing tripeptides and/or peptides longer than tripeptides
    发明人:YOKOZEKI KENZO; SUZUKI SONOKO; HARA SEIICHI; ABE ISAO
    权利人:AJINOMOTO KK
    摘要:It is an object of the present invention to provide a method that allows the production of peptides that are equal to or longer than tripeptides easily, inexpensively and at high yield without going through a complex synthesis method. The inventors of the present invention have found a novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empedobacter or the genus Sphingobacterium . In the present invention, this enzyme is allowed to act on a carboxy component and an amine component to produce peptides that are equal to or longer than tripeptides.

    专利号:WO-9414835-A1
    优先权日:1992-12-28
    标题 :Use of molecularly imprinted polymers for stereo- and/or regioselective synthesis

    专利号:US-6884842-B2
    优先权日:1997-10-14
    标题:Molecular compounds having complementary surfaces to targets
    发明人:SOANE DAVID S; BARRY STEPHEN E; GOODWIN ANDREW; OFFORD DAVID A; PERROTT MICHAEL G
    权利人:ALNIS BIOSCIENCES INC
    摘要:Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs may have surfaces that include functional groups that are complementary to surface sites of targets such as nanostructures or macromolecular targets, and may be capable of specifically interacting with such targets. The positions of the functional groups in one embodiment are stabilized by a polymer network. The SPCs are formed by contacting the target with a set of monomers which self-assemble on the target, and then are polymerized into a network to form the synthetic polymer complement. At least a portion of the surface of the resulting SPC thus may include an imprint of the target. The complex of the SPC and the target may be the desired product. Alternatively, the target is released, for example, by controllably expanding and contracting the crosslinked network. The SPC is isolated and used in many applications.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Aleksandra Zimmermann, Et Al. Surface Charge Fine Tuning Of Reversed-Phase/weak Anion-Exchange Type Mixed-Mode Stationary Phases For Milder Elution Conditions. J Chromatogr A. 2015 Aug 28:1409:189-200.
    [参考文献]: D A Johnson, Et Al. The Effect Of Enzymatic Reaction On Dissolution Rate: Theoretical Analysis And Experimental Test. J Pharm Sci. 1986 Feb;75(2):195-203.
    [参考文献]: Hua Zhao, Et Al. High Transesterification Activities Of Immobilized Proteases In New Ether-Functionalized Ionic Liquids. Biotechnol Lett. 2010 Aug;32(8):1109-16.
    [参考文献]: Hua Zhao, Et Al. Protease Activation In Glycerol-Based Deep Eutectic Solvents. J Mol Catal B Enzym. 2011 Nov 1;72(3-4):163-167.
    [参考文献]: J A Laszlo, Et Al. Alpha-Chymotrypsin Catalysis In Imidazolium-Based Ionic Liquids. Biotechnol Bioeng. 2001 Oct 20;75(2):181-6.

    合成参考文献


    摘要:Braverman, S.; Cherkinsky, M., Science of Synthesis Knowledge Updates, (2014) 3, 240.
    摘要:Mourad, A. K.; Czekelius, C., Science of Synthesis Knowledge Updates, (2011) 3, 83.
    参考文献:10.1002/bit.1173
    摘要:van Unen DJ, Engbersen JF, Reinhoudt DN. Sol-gel immobilization of serine proteases for application in organic solvents. Biotechnol Bioeng. 2001 Oct 20;75(2):154–8. doi: 10.1002/bit.1173.
    参考文献:10.1002/bit.1177
    摘要:Laszlo JA, Compton DL. Alpha-chymotrypsin catalysis in imidazolium-based ionic liquids. Biotechnol Bioeng. 2001 Oct 20;75(2):181–6. doi: 10.1002/bit.1177.
    参考文献:10.1007/978-1-4939-2978-8_6
    摘要:Handen JD, Lednev IK. Deep UV Resonance Raman Spectroscopy for Characterizing Amyloid Aggregation. Methods Mol Biol. 2016;1345():89–100. doi: 10.1007/978-1-4939-2978-8_6.
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