专利号:US-2005027102-A1 优先权日:1992-12-28 标题 :Use of molecularly imprinted polymers for stereo- and/or regioselective synthesis 发明人:MOSBACH KLAUS; NICHOLLS IAN A; RAMSTROM OLOF 摘要:Molecularly imprinted polymers can be utilized in stereo- and regio-selective synthesis. These systems can be utilized, e.g. for peptide synthesis, by selectively coordinating reactants at a predetermined preformed cavity. Further, such polymers may be used for the selective removal of one enantiomeric species from solution, allowing reaction to be directed to another species in bulk solution leading to stereoselective and/or regio-selective synthesis in the cavity of for instance peptides. Additionally, when utilized as regioselectively interacting protectioning matrices, these polymers can direct reaction to an alternate centre of a reacting substrate.
专利号:EP-0675898-B1 优先权日:1992-12-28 标题 :Use of molecularly imprinted polymers for stereo- and/or regioselective synthesis 发明人:MOSBACH KLAUS; NICHOLLS IAN A; RAMSTROEM OLOF 权利人:MOSBACH KLAUS H 摘要:Molecularly imprinted polymers can be utilized in stereo- and regio-selective synthesis. These systems can be utilized, e.g. for peptide synthesis, by selectively coordinating reactants at a predetermined preformed cavity. Further, such polymers may be used for the selective removal of one enantiomeric species from solution, allowing reaction to be directed to another species in bulk solution leading to stereoselective and/or regioselective synthesis in the cavity of for instance peptides. Additionally, when utilized as regioselectively interacting protectioning matrices, these polymers can direct reaction to an alternate centre of a reacting substrate.
专利号:US-2005032187-A1 优先权日:2003-08-01 标题:Novel peptide-forming enzyme, microbe producing the enzyme and method for producing peptide using them 发明人:YOKOZEKI KENZO; SUZUKI SONOKO; HARA SEIICHI; KATAYAMA SATOSHI 权利人:AJINOMOTO KK 摘要:The present invention relates to a novel enzyme that allows peptide to be produced easily, inexpensively and at high yield without going through a complex synthesis method. More particularly, the present invention provides a novel enzyme that catalyzes a peptide-producing reaction from a carboxy component and an amine component, a microbe that produces the enzyme, and a method for inexpensive production of peptides using this enzyme or microbe. The novel enzyme that efficiently produces peptide was discovered from a newly discovered microbe belonging to the genus Empedobacter , and a method was found that allows peptides to be produced inexpensively and easily.
专利号:US-2005032154-A1 优先权日:2002-07-26 标题 :Method for producing tripeptides and/or peptides longer than tripeptides 发明人:YOKOZEKI KENZO; SUZUKI SONOKO; HARA SEIICHI; ABE ISAO 权利人:AJINOMOTO KK 摘要:It is an object of the present invention to provide a method that allows the production of peptides that are equal to or longer than tripeptides easily, inexpensively and at high yield without going through a complex synthesis method. The inventors of the present invention have found a novel enzyme that efficiently produces a peptide from bacteria belonging to the genus Empedobacter or the genus Sphingobacterium . In the present invention, this enzyme is allowed to act on a carboxy component and an amine component to produce peptides that are equal to or longer than tripeptides.
专利号:WO-9414835-A1 优先权日:1992-12-28 标题 :Use of molecularly imprinted polymers for stereo- and/or regioselective synthesis
专利号:US-6884842-B2 优先权日:1997-10-14 标题:Molecular compounds having complementary surfaces to targets 发明人:SOANE DAVID S; BARRY STEPHEN E; GOODWIN ANDREW; OFFORD DAVID A; PERROTT MICHAEL G 权利人:ALNIS BIOSCIENCES INC 摘要:Synthetic polymer complements (SPCs) are provided, as well as methods for their synthesis and use. The SPCs may have surfaces that include functional groups that are complementary to surface sites of targets such as nanostructures or macromolecular targets, and may be capable of specifically interacting with such targets. The positions of the functional groups in one embodiment are stabilized by a polymer network. The SPCs are formed by contacting the target with a set of monomers which self-assemble on the target, and then are polymerized into a network to form the synthetic polymer complement. At least a portion of the surface of the resulting SPC thus may include an imprint of the target. The complex of the SPC and the target may be the desired product. Alternatively, the target is released, for example, by controllably expanding and contracting the crosslinked network. The SPC is isolated and used in many applications.
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合成参考文献
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