CAS: 19763-90-7; 3,4-Dichlorophenylhydrazine Hydrochloride

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CAS号95-76-1 3,4-二氯苯胺 | CAS号58791-78-9 5-氨基-1-(3,4-二氯苯... | CAS号13124-03-3 N'-(3,4-dichlor... | CAS号13124-18-0 (3,4-二氯苯基)肼 | CAS号13124-09-9 2-(3,4-二氯苯基)-1-... | CAS号2974-92-7 3,4-二氯联苯 | CAS号76606-68-3 2-(3,4-二氯苯基)-5-... | CAS号66000-43-9 3-氨基-1-(3,4-二氯苯基)吡唑 | CAS号877179-04-9 2-(3,4-二氯苯基)-4-氟苯胺 | CAS号479422-01-0 4,5-二氯-2-甲基-1H-吲哚 | CAS号479422-03-2 5,6-二氯-2-甲基-1H-吲哚

3,4-二氯苯胺置于盐酸,Sodium Nitrite,Tin(Ll) Chloride体系中,用 水 用作溶剂,化学反应 1.5H,反应生成3,4-二氯苯肼盐酸盐
参考文献:发现了以ftsz为目标的含1,3,4-恶二唑-2-酮的苯甲酰胺衍生物,可作为杀死多种mdr细菌菌株的高效药物.
标题:发现了以ftsz为目标的含1,3,4-恶二唑-2-酮的苯甲酰胺衍生物,可作为杀死多种mdr细菌菌株的高效药物.
摘要:由耐多药(mdr)病原体(例如耐甲氧西林的金黄色葡萄球菌(mrsa)和耐万古霉素的金黄色葡萄球菌(vrsa))引起的感染扩散,引起了人们对具有新作用机制的新型抗生素的需求.细菌分裂蛋白ftsz已被鉴定为可在临床上开发的新型药物靶标.作为开发靶向ftsz的抗菌剂的持续努力的一部分,我们在此描述了六种系列的新型含1,3,4-恶二唑-2-One,1,2,4-三唑-的设计,合成和生物活性.含3-One和含吡唑啉-5-One的苯甲酰胺衍生物.其中,化合物a14被发现是最有效的抗菌剂,对所有测试的革兰氏阳性菌株均优于环丙沙星,利奈唑胺和红霉素等临床药物,特别是耐甲氧西林,耐青霉素和临床分离的金黄色葡萄球菌.随后的生物学活性和对接分析研究证明,A14可以作为靶向ftsz的有效化合物.初步的sar表明了进一步优化这些新颖类似物的总体方向.综上所述,这项研究为开发新型靶向ftsz的杀菌剂提供了有希望的化学型.
Doi:10.1016/j.Bmc.2019.06.010

专利信息

专利号:US-2008119524-A1
优先权日:2002-08-14
标题 :Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use
发明人：BROWN BRADLEY B; REHDER KENNETH S; STRACHAN JON-PAUL; EAVES JERON H; LOWDEN CHRISTOPHER T
权利人:BROWN BRADLEY B; REHDER KENNETH S; STRACHAN JON-PAUL; EAVES JERON H; LOWDEN CHRISTOPHER T
摘要:The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.

专利号:US-7166619-B2
优先权日:2002-08-14
标题 :Prenylation inhibitors and methods of their synthesis and use
发明人：LI FRANCINE FEIRONG; REHDER KENNETH S; CAMPBELL MICHAEL GORDON; VISCARDI CELESTE PATRICE; STRACHAN JON-PAUL; GUO ZHENGMING
权利人:PPD DISCOVERY INC
摘要:The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.

专利号:US-7501446-B2
优先权日:2002-08-14
标 题 :Prenylation inhibitors and methods of their synthesis and use
发明人：LI FRANCINE FEIRONG; REHDER KENNETH S; CAMPBELL MICHAEL GORDON; VISCARDI CELESTE PATRICE; STRACHAN JON-PAUL; GUO ZHENGMING
权利人:PPD DISCOVERY INC
摘要:The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.

专利号:US-2005004122-A1
优先权日:2002-08-14
标题 :Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use

专利号:US-7112596-B2
优先权日:2002-08-14
标题:Prenylation inhibitors and methods of their synthesis and use

专利号:US-2006025454-A1
优先权日:2002-08-14
标题 :Prenylation inhibitors and methods of their synthesis and use