CAS: 17282-04-1; 2-Chloro-3-Fluoropyridine

上下游产品

CAS号372-47-4 3-氟吡啶 | CAS号280-57-9 三乙烯二胺 | CAS号67-72-1 六氯乙烷 | CAS号6298-19-7 2-氯-3-氨基吡啶 | CAS号78948-09-1 acetyl hypofluorite | CAS号462-08-8 3-氨基吡啶 | CAS号109613-91-4 2-氯-3-甲氧基-4-硝基吡啶 | CAS号109613-90-3 2-氯-3-氟-4-硝基吡啶 | CAS号149488-78-8 2-(3-氟吡啶-2-基)乙腈 | CAS号946127-54-4 (2-氯-3-氟吡啶-4-基)甲醇 | CAS号628691-93-0 2-氯-3-氟异烟酸 | CAS号101664-59-9 2-氯-3,4-二甲氧基吡啶盐酸盐 | CAS号101664-56-6 2-氯-3-氟-4-硝基吡啶氮氧化物 | CAS号139022-26-7 8-氟咪唑并[1,2-a]吡啶 | CAS号146141-04-0 3-氟-2-碘吡啶 | CAS号148639-07-0 2-氯-3-氟-4-碘吡啶

3-氟吡啶置于三乙烯二胺,正丁基锂,六氯乙烷体系中,用 乙醚,正己烷 用作溶剂,化学反应 1.0H,以53%的收率获得2-氯-3-氟吡啶
参考文献:索普-英戈尔德效应在未活化芳基氟化物的支链选择性烷基化中
标题:索普-英戈尔德效应在未活化芳基氟化物的支链选择性烷基化中
摘要:本文提出了通过镍催化用无偏的二次格氏试剂将简单的芳基氟化物烷基化的一般方案.这项研究揭示了配体主链上普遍的索普-英戈尔德效应,在cc偶合事件中赋予了次级碳中心高度的选择性.该协议的特点是反应条件温和,稳健且简单.富电子和缺电子的芳基氟化物都是该转化的合适候选物.同样适合的是各种杂环,允许偶联而在亲电子位点没有过度烷基化.
Doi:10.1002/anie.201804479

专利信息

专利号:US-2024101516-A1
优先权日:2021-01-20
标 题:Synthesis of polyfluorinated aryl and heteroaryl carboxamides
发明人：KADUSKAR RAHUL; BORATE KAILASKUMAR; ADHAV SUYOG; THIRUNAVUKKARASU SARAVANAN; SHINDE HARISH; GOETZ ROLAND
权利人:BASF SE
摘要:The presently claimed invention relates to a process for the preparation of mono-, di-, tri-, fluoro arylamide or hetroarylamide.

专利号:US-9574189-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries
发明人：FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK
权利人:FRANCH THOMAS; LUNDORF MIKKEL DYBRO; JACOBSEN SØREN NYBOE; OLSEN EVA KAMPMANN; ANDERSEN ANNE LEE; HOLTMANN ANETTE; HANSEN ANDERS HOLM; SØRENSEN ANDERS MALLING; GOLDBECH ANNE; DE LEON DAEN; KALDOR DITTE KIEVSMOSE; SLØK FRANK ABILDGAARD; HUSEMOEN GITTE NYSTRUP; DOLBERG JOHANNES; Jensen Kim Birkebæ; PEDERSEN LENE; NØRREGAARD-MADSEN MADS; GODSKESEN MICHAEL ANDERS; GLAD SANNE SCHRØDER; NEVE SØREN; THISTED THOMAS; KRONBORG TINE TITILOLA AKINLEMINU; SAMS CHRISTIAN KLARNER; FELDING JAKOB; FRESKGÃ…RD PER-OLA; GOULIAEV ALEX HAAHR; PEDERSEN HENRIK; NUEVOLUTION AS
摘要:Disclosed is a method for obtaining a bifunctional complex comprising a molecule linked to a single stranded identifier oligonucleotide, wherein a nascent bifunctional complex comprising a chemical reaction site and a priming site for enzymatic addition of a tag is a) reacted at the chemical reaction site with one or more reactants, and b) reacted enzymatically at the priming site with one or more tag(s) identifying the reactant(s).

专利号:WO-2024064745-A1
优先权日:2022-09-21
标 题:Synthesis of reldesemtiv
发明人：PETERSON MATTHEW W; LU QING; MORGAN BRADLEY P; ASHCRAFT LUKE W; ANDERSEN DENISE
权利人:CYTOKINETICS INC
摘要:Provided herein is a process for the preparation of reldesemtiv and salts thereof. Also provided herein are intermediates used in this process and their preparation.

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:US-2009264300-A1
优先权日:2005-12-01
标题 :Enzymatic encoding methods for efficient synthesis of large libraries