CAS: 1621-91-6; 1H-Pyrazole-3-Carboxylic Acid

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CAS号1453-58-3 3-甲基吡唑 | CAS号5932-27-4 3-乙氧羰基吡唑 | CAS号20154-03-4 3-三氟甲基吡唑 | CAS号221300-34-1 1H-Pyrazole-3-c... | CAS号144677-14-5 2-(1H-pyrazol-3... | CAS号87581-74-6 1-benzylpyrazol... | CAS号20583-33-9 3-乙酰基吡唑 | CAS号87879-93-4 4-diazo-1,1,1,2... | CAS号79-10-7 丙烯酸 | CAS号138813-24-8 4H,9H-Dipyrazol... | CAS号5932-27-4 3-乙氧羰基吡唑 | CAS号21056-77-9 1H-吡唑-5-羧酸乙酯 | CAS号288-13-1 吡唑 | CAS号16034-46-1 1-甲基-1H-吡唑-5-羧酸 | CAS号25016-20-0 1-甲基吡唑-3-甲酸 | CAS号23585-49-1 3-(羟甲基)吡唑 | CAS号84547-87-5 4-氯-1H-吡唑-5-羧酸 | CAS号6647-93-4 4-碘-1H-吡唑-5-羧酸 | CAS号13745-17-0 4-溴-1H-吡唑-3-甲酸

3-甲基吡唑置于potassium Permanganate体系中,化学反应 4.0H,以100%的收率获得吡唑-3-甲酸
参考文献:具有程序化分子间相互作用的镧系元素:通过与环糊精的结合和钆自聚集体的异常大松弛来增强发光
标题:具有程序化分子间相互作用的镧系元素:通过与环糊精的结合和钆自聚集体的异常大松弛来增强发光
摘要:报道了苯基锚定荚果和 H4L1 的合成,该 H4L1 配有四个 3-羧酸吡唑臂并为分子间相互作用编程,并确定了其质子化常数.与稀水溶液中的 Ln3+ 离子(ln = La,Eu,Lu)相互作用,生成金属配体化学计量比为 1:1 和 1:2 的络合物.稳定性常数在 Log β110 = 12.7−13.5 和 Log β120 = 22.5−23.8 范围内(pln 值在 9−10 范围内).在 Tbiii 的情况下,足状体显示出对金属中心发光的相当敏感,绝对量子产率为 5%.根据寿命测量结果,对于 1:1 Eu 和 Tb Podates,与 Lniii 离子配位的水分子的平均数量分别为 3.8 和 4.9.将β-和γ-环糊精添加到1中:
Doi:10.1021/ja001089B

专利信息

专利号:US-2022372000-A1
优先权日:2021-05-05
标 题:New Process for the Synthesis of 5-Fluoro-3-(Difuoromethyl)-5-Fluoro-1-Methyl-1H-Pyrazole-4-Carboxylic Acid Derivatives and the Free Acid Thereof
发明人：LUO WEIFEN; WU WENTING
权利人:FUJIAN YONGJING TECH CO LTD
摘要:The invention provides a new process for the synthesis of 5-fluoro-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid derivatives and the free acid thereof, involving a direct fluorination reaction with a fluorination gas comprising or consisting of elemental fluorine (F2), in a reactor which is resistant to elemental fluorine (F2) and hydrogen fluoride (HF), and wherein in the process as a starting material a difluoromethyl-pyrazole compound dissolved in an inert solvent is subjected to the direct fluorination reaction. Some particular examples of 5-fluoro-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid derivatives which can be prepared according to the process of the invention are 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid fluoride (5F-DFMPAF), also known under the alternative name 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carbonyl fluoride; 3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid ethylester (5F-DFMP); and 3-(chlorodifluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid ethylester (5F-CDFMP), or the corresponding methyl esters. The 5-fluoro-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxylic acid can be obtained from its carboxylic acid derivatives such as, e.g., mentioned before in that the acid derivative is converted to the corresponding carboxylic acid.

专利号:WO-2017089470-A1
优先权日:2015-11-27
标 题:Process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases
发明人：HOFMANN DAGMAR; HOFMANN JOSEFA; HEINRICH MARKUS
权利人:Friedrich-Alexander-Universität Erlangen-Nürnberg
摘要:The present invention relates to a process for the synthesis of aryldiazonium salts using nitrogen oxides in oxygen-containing gas streams, especially from industrial waste gases.

专利号:US-2013338369-A1
优先权日:2011-03-07
标 题 :Process for the Synthesis of Aminobiphenylene
发明人：HEINRICH MARKUS; PRATSCH GERALD
权利人:HEINRICH MARKUS; PRATSCH GERALD; BASF SE
摘要:The present invention relates to a process for the synthesis of 2-aminobiphenylene and derivatives thereof by reacting a benzene diazonium salt with an aniline compound under basic reaction conditions.

专利号:US-8629288-B2
优先权日:2008-02-25
标题:Method for the regioselective synthesis of 1-alky1-3-haloalkyl-pyrazole-4-carboxylic acid derivatives
发明人：PAZENOK SERGII; LUI NORBERT; HEINRICH JENS-DIETMAR; WOLLNER THOMAS
权利人:PAZENOK SERGII; LUI NORBERT; HEINRICH JENS-DIETMAR; WOLLNER THOMAS; BAYER IP GMBH
摘要:The present invention relates to a process for the regioselective synthesis of 1-alkyl-3-halo-alkylpyrazole-4-carboxylic acid derivatives by cyclization of 2,3-disubstituted acrylic acid derivatives, and to the hydrazones formed as intermediates in the process.

专利号:WO-2021033172-A1
优先权日:2019-08-20
标题:Process for the preparation of chlorantraniliprole
发明人：V ASHWIN; PRADHAN ASHOK KUMAR; PALIMKAR SANJAY SAMBHAJIRAO; MANE AVINASH SHESHRAO; KUNHIMON SYAM KUMAR UNNIARAN
权利人:EUROFINS ADVINUS LTD
摘要:The present invention relates to two novel, efficient and one-pot methods for synthesizing chlorantraniliprole. In the first scheme, Chlorantraniliprole is prepared by a novel telescopic process starting from 3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid a key raw material-A (Key RM-A). In the second scheme, starting from Key RM-A, the process steps use of a novel variant of anthranilic acid (Methyl 2-amino-5-chloro-3-methylbenzoate), to get Chlorantraniliprole. Furthermore, the present invention also relates to the synthesis of key starting material for the synthesizing chlorantraniliprole in-situ. All the in-situ steps of the disclosed synthesis methods obtain good yield, without using any expensive reagent or base or harsh reaction conditions, which makes the process simple, environment friendly and more cost effective. With this process the production cost of chlorantraniliprole and its intermediates is substantially reduced; fewer by-products are formed during its synthesis and since it's a one-pot reaction, isolation and purification are easy to achieve.

专利号:US-2006069270-A1
优先权日:2004-09-27
标 题 :Process for the preparation of 1,3,5-trisubstituted pyrazoles via [3+2] cycloaddition
发明人：SHAPIRO RAFAEL; ROSSANO LUCIUS T; TENHUISEN KAREN L
权利人:SHAPIRO RAFAEL; ROSSANO LUCIUS T; TENHUISEN KAREN L
摘要:A process for the preparation of 1,3,5-trisubstituted pyrazole compounds, which are useful intermediates in the synthesis of factor Xa inhibitors.