CAS: 1493764-08-1; N-(4-(1H-Imidazol-1-yl)Benzyl)-2-(Butylamino)-4-((Trans-4-Hydroxycyclohexyl)Amino)Pyrimidine-5-Carboxamide
- 英文名称N-(4-(1H-Imidazol-1-yl)Benzyl)-2-(Butylamino)-4-((Trans-4-Hydroxycyclohexyl)Amino)Pyrimidine-5-Carboxamide
- 中文名称2-(丁基氨基)-4-[(反式-4-羟基环己基)氨基]-N-[[4-(1H-咪唑-1-基)苯基]甲基]-5-嘧啶甲酰胺
- IUPAC名称N-(4-(1H-imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide
- CAS编号1493764-08-1
- MFCD编号:MFCD28142814
- EINECS号:106-867-2
- 分子式:C25H33N7O2分子量:463.59
- 产品CID: 719844
- 产品分类Chemistry → Heterocyclic Building Blocks → Pyrimidines | Inhibitors/Agonists → Anti-infection → Influenza Virus | Protein Tyrosine Kinase/RTK → TAM Receptor
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
2,4-dichloro-5-pyrimidinecarboxylic acid methyl ester -1H-imidazole1-4-(aminomethyl)phenyl-1H-imidazole 2,4-dichloropyrimidine-5-carbonyl chloride合成工艺路线路线简述
海关参考信息
- 2902300000-甲苯
2905122000-异丙醇
2912110000-甲醛
2905142000-仲丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:CN-108379591-B
优先权日:2018-04-03
标 题 :Synthesis of Immune Agonist Targeting Compounds and Their Applications
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Zhang W, McIver AL, Stashko MA, Deryckere D, Branchford BR, Hunter D, Kireev D, Miley MJ, Norris-Drouin J, Stewart WM, Lee M, Sather S, Zhou Y, Di Paola JA, Machius M, Janzen WP, Earp HS, Graham DK, Frye SV, Wang X. Discovery of Mer Specific Tyrosine Kinase Inhibitors for the Treatment and Prevention of Thrombosis. J Med Chem. 2013 Nov 20. 56(23): 9693–9700.
合成参考文献
参考文献:10.1124/mol.119.115964
摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
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