CAS: 13850-16-3; (1R,2R,4As,6As,6Br,8Ar,10R,11R,12Ar,12Br,14Bs)-1,10,11-Trihydroxy-1,2,6A,6B,9,9,12A-Heptamethyl-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Icosahydropicene-4A-Carboxylic Acid
该化合物是一种主要存在于各种植物物种中,特别是异族动物* 的自然生成的三元素化合物,其特征为可促进其生物活动的五环结构,该化合物具有一系列药理特性,包括抗炎,抗氧化剂和潜在的抗癌效应,使其对药用化学和药理具有兴趣.毒性酸通常在有机溶剂中溶解,但在水中溶解性有限,这对许多异族动物来说是常见的.其化学结构允许它与各种生物目标互动,影响细胞路径.此外,对治疗性酸的研究突出显示了其在草药和药物开发的铅化合物中的潜在应用.
- 英文名称(1R,2R,4As,6As,6Br,8Ar,10R,11R,12Ar,12Br,14Bs)-1,10,11-Trihydroxy-1,2,6A,6B,9,9,12A-Heptamethyl-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-Icosahydropicene-4A-Carboxylic Acid
- 中文名称2α,19α-二羟基熊果酸
- IUPAC名称(1R,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid
- 其它别名2α,19α－dihydroxyursolic Acid; 2α,3β,19-Trihydroxyurs-12-En-28-Oic Acid; 2α,3β,19α-Trihydroxy-19-Methyl-30-Noroleana-12-Ene-28-Oic Acid; 2α,3β,19α-Trihydroxyurs-12-En-28-Oic Acid; Tormentic Acid; Potentillary Acid, 2_, 19_-Dihydroxy Ursolic Acid; Urs-12-En-28-Oic Acid, 2,3,19-Trihydroxy-, (2α,3β)-; (1R,2R,4As,6Ar,6As,6Br,8Ar,10R,11R,12Ar,14Bs)-1,10,11-Trihydroxy-1,2,6A,6B,9,9,12A-Heptamethyl-2,3,4,5,6,6A,7,8,8A,10,11,12,13,14B-Tetradecahydropicene-4A-Carboxylicaci
- CAS编号13850-16-3
- MFCD编号:MFCD09970923
- FDA UNII编号:9WL8LH7U78
- 分子式:C30H48O5分子量:488.71
- 产品CID: 598018
- 产品分类天然产物 → 萜类
物理性质
上下游产品
3-O-trans-p-coumaroyltormentic acid 2α,19α-dihydroxy-5α,9α-urs-12-en-3-one-28-oic acid-28-O-β-D-glucopyranosyl ester 2α,3α,19α-trihydroxyurs-12-en-28-oic acid 28-β-D-glucopyranosyl ester 2α,3α-diacetoxy-19α-hydroxyurs-12-en-28-oic acid (2R,3R,19R)-2,3-bis(acetyloxy)-19-hydroxyurs-12-en-28-carboxylic acid methyl 2α,3β,19-trihydroxyurs-12-en-28-oate Diacetyl-tormentsaeure-methylester (2R,3R,19R)-3-acetyloxy-2,19-dihydroxyurs-12-en-28-carboxylic acid合成工艺路线路线简述
📜Serratolide置于氢氧化钾体系中,用 甲醇 用作溶剂,化学反应生成2Alpha,19Alpha-二羟基熊果酸
参考文献:来自 Myrianthus Serratus 的 E 环 γ-内酯五环三萜
标题:来自 Myrianthus Serratus 的 E 环 γ-内酯五环三萜
摘要:一种新型 γ-内酯三萜类化合物已从 Myrianthus Serratus 树干木材的甲基化乙酸乙酯提取物中分离出来,以及 Friedelin 和四种已知的五环三萜酸,所有这些都是它们的甲酯.通过二维核磁共振实验阐明了它们的结构.
Doi:10.1016/s0031-9422(98)00292-1
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📌 第三方产品分析报告
主要参考文献
1: Olech M, Ziemichód W, Nowacka-Jechalke N. The Occurrence and Biological Activity of Tormentic Acid-A Review. Molecules. 2021 Jun 22;26(13):3797. doi: 10.3390/molecules26133797.
2: Wu J, Wang N, Jin G, Xue L. Tormentic acid induces anticancer effects in cisplatin-resistant human cervical cancer cells mediated via cell cycle arrest, ROS production, and targeting mTOR/PI3K/AKT signalling pathway. J BUON. 2020 Jan-Feb;25(1):74-79. 12(1):13005. doi: 10.1038/s41598-022-17478-4.
4: Shi C, Li Z, Wu Y, Li X, Li Y, Wei J, Li J, Zhang Y, Li L. Euscaphic acid and Tormentic acid protect vascular endothelial cells against hypoxia-induced apoptosis via PI3K/AKT or ERK 1/2 signaling pathway. Life Sci. 2020 Jul 1;252:117666. doi: 10.1016/j.lfs.2020.117666. Epub 2020 Apr 13. 39(1):77-87. doi: 10.1002/cbf.3564. Epub 2020 Jun 21. Retraction in: Cell Biochem Funct. 2021 Oct;39(7):921. doi: 10.1002/cbf.3666.
合成参考文献
参考文献:10.1016/s0167-4838(02)00227-3
摘要:Murakami C, Ishijima K, Hirota M, Sakaguchi K, Yoshida H, Mizushina Y. Novel anti-inflammatory compounds from Rubus sieboldii, triterpenoids, are inhibitors of mammalian DNA polymerases. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 2002 Apr;1596(2):193–200. doi: 10.1016/s0167-4838(02)00227-3.
参考文献:10.1007/bf02980076
摘要:Jin JL, Lee YY, Heo JE, Lee S, Kim JM, Yun-Choi HS. Anti-platelet pentacyclic triterpenoids from leaves of Campsis grandiflora. Arch Pharm Res. 2004 Apr;27(4):376–80. doi: 10.1007/bf02980076.
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