CAS: 137129-98-7; 6-Chloro-2-Methylnicotinic Acid

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66909-36-2 884495-36-7 31163-12-9

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CAS号31163-12-9 6-氯-2-甲基烟酸乙酯 | CAS号62366-52-3 3-Pyridinecarbo...

📜6-氯-2-甲基烟酸乙酯置于水,Lithium Hydroxide体系中,用 四氢呋喃 用作溶剂,化学反应生成6-氯-2-甲基烟酸
参考文献:Second Generation 2-Pyridyl Biphenyl Amide Inhibitors Of The Hedgehog Pathway
标题:Second Generation 2-Pyridyl Biphenyl Amide Inhibitors Of The Hedgehog Pathway
摘要:Potent And Efficacious Inhibitors Of The Hedgehog Pathway For The Treatment Of Cancer Have Been Prepared Using The 2-Pyridyl Biphenyl Amide Scaffold Common To The Clinical Lead Gdc-0449. Analogs With Polar Groups In The Para-Position Of The Aryl Amide Ring Optimized Potency,Had Minimal Cyp Inhibition,And Possessed Good Exposure In Rats. Compounds 9D And 14F Potently Inhibited Hedgehog Signaling As Measured By Gli1 Mrna And Were Found To Be Equivalent Or More Potent Than Gdc-0449,Respectively,When Studied In A Ptch(+/) Medulloblastoma Allograft Model,That Is,Highly Dependent On Hedgehog Signaling. (C) 2010 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Bmcl.2010.08.134

专利信息

专利号:WO-2023122754-A1
优先权日:2021-12-23
标 题 :Processes and intermediates for preparing gb13, gb22 and himgaline
发明人：LANDWEHR ELEANOR; SHENVI RYAN; BAKER MEGHAN; OGUMA TAKUYA
权利人:SCRIPPS RESEARCH INST
摘要:Provided herein are processes for the streamlined synthesis of Galbulimima alkaloids, such as himbadine, isolated from Galbulimima belgraveana and G. baccatta, trees endemic to the rainforests of Northern Australia and Papua New Guinea, as well as analogs thereof, such as GB13, GB16, GB22, and himgaline, and further including intermediates useful in the synthesis of these and related compounds.