CAS: 13431-34-0; N-Ethylhydrazinecarbothioamide

相似化合物

13431-36-2 13431-41-9 21198-26-5

上下游产品

CAS号542-85-8 异硫氰酸乙酯 | CAS号75-15-0 二硫化碳 | CAS号75-04-7 乙胺 | CAS号7803-57-8 水合肼 | CAS号5397-03-5 肼基二硫代甲酸甲酯 | CAS号542-85-8 异硫氰酸乙酯 | CAS号31409-15-1 N-(ethylthi°Car... | CAS号741250-20-4 1-(dipyridin-2-... | CAS号76609-52-4 3-ethyl-1-[(3-m... | CAS号80550-04-5 1-(benzylidenea... | CAS号827307-62-0 1-ethyl-3-(1-ph... | CAS号91265-79-1 N-ethyl-5-pheny... | CAS号918879-29-5 1-ethyl-3-(3-ox...

📜异硫氰酸乙酯置于一水合肼,异丙醇体系中,化学反应 0.17H,反应生成4-乙基-3-硫代氨基脲
参考文献:二芳基取代氨基硫脲:开发新德里金属-β-内酰胺酶-1抑制剂的有效支架
标题:二芳基取代氨基硫脲:开发新德里金属-β-内酰胺酶-1抑制剂的有效支架
摘要:由新德里金属-β-内酰胺酶(ndm-1)引起的超级细菌感染已成为一种新兴的公共卫生威胁.由于 Ndm-1 在病原菌之间穿梭,因此抑制 Ndm-1 已被证明具有挑战性.构建了一种有效的支架,二芳基取代的缩氨基硫脲,并用金属-β-内酰胺酶 (Mβls) 进行了测定.获得的 26 个分子特异性抑制 Ndm-1,Ic 50 0.038-34.7 µm 范围(1E,2E和3D除外),1C是最有效的抑制剂(ic 50 = 0.038 µm).合成缩氨基硫脲的构效关系表明,二芳基取代物,特别是 2-吡啶和 2-羟基苯提高了抑制剂的抑制活性.缩氨基硫脲对大肠杆菌-Ndm-1表现出协同抗分枝杆菌作用,导致美罗培南的 Mic 降低 2-512 倍,而1C恢复抗生素对临床分离株的 16-256-,16-和 2 倍的活性ecs,肺炎克雷伯菌和铜绿假单胞菌分别含有 Ndm-1.此外,小鼠实验表明,1C与美罗培南具
Doi:10.1016/j.Bioorg.2020.104576

专利信息

专利号:US-4412079-A
优先权日:1968-03-13
标题:Thiadiazole compounds and methods of using said compounds in agriculture
发明人：CEBALO TONY; WALDE ROBERT A
权利人:AIR PROD & CHEM
摘要:Novel thiadiazole compounds are disclosed which contain in the 5 position, C-linked moieties which are either acyclic hydrocarbon radicals or halogenated acyclic hydrocarbon radicals (in which case each halogen is independently selected from F, Cl and Br). These novel compounds also contain an exocyclic nitrogen in the 2 position, and some of them contain the exocyclic substituent: wherein R3 is a lower acyclic hydrocarbon radical and R4 is either H or a lower acyclic hydrocarbon radical. Synthesis of these compounds is disclosed, including synthesis of those which exhibit isomerism and/or tautomerism. Various of these compounds have various agricultural utilities (e.g. as herbicides, insecticides, acaricides and fungicides), each of them having at least one such biological utility. Methods of using these compounds in phytotoxic fungicidal, acaricidal and insecticidal applications are disclosed.

专利号:EP-2864334-A1
优先权日:2012-06-25
标题:Synthesis of thiosemicarbazides and triazoles derived from etodolac

专利号:WO-2014003694-A1
优先权日:2012-06-25
标题 :Synthesis of thiosemicarbazides and triazoles derived from etodolac

专利号:US-2006211603-A1
优先权日:2004-08-18
标 题:Ramoplanin derivatives possessing antibacterial activity
发明人：RAJU BORE G; CIABATTI ROMEO; MAFFIOLI SONIA I; SINGH UPINDER; ROMANO GABRIELLA; MICHELUCCI ELENA; TISENI PAOLO S; CANDIANI GIANPAOLO; KIM BUM; O'DOWD HARDWIN
权利人:VICURON PHARM INC
摘要:Novel ramoplanin derivatives are disclosed. These ramoplanin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against gram positive bacteria, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

专利号:CN-107652267-B
优先权日:2017-10-30
标题:Synthesis and application of solid-state reversible pyrazolone photochromic compounds

专利号:CN-107652267-A
优先权日:2017-10-30
标题:Synthesis and application of solid-state reversible pyrazolone photochromic compounds