CAS: 1201186-54-0; 2-Bromo-5-Tosyl-5H-Pyrrolo[2,3-B]Pyrazine

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875781-43-4 875781-45-6 1207625-13-5

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CAS号875781-43-4 5-溴-4,7-二氮杂吲哚 | CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号875781-41-2 5-溴-3-((三甲基硅基)乙...

5-Tosyl-5H-Pyrrolo[2,3-B]Pyrazin-2-Amine置于硫酸,氢溴酸,Sodium Nitrite体系中,化学反应 2.5H,反应生成N-甲苯磺酰基-5-溴-4,7-二氮杂吲哚
参考文献:(5-甲苯磺酰基-5H-吡咯并[2,3-B]吡嗪-2-基)氨基甲酸叔丁酯的制备
标题:(5-甲苯磺酰基-5H-吡咯并[2,3-B]吡嗪-2-基)氨基甲酸叔丁酯的制备
摘要:本发明涉及一种(5‑甲苯磺酰基‑5H‑吡咯并[2,3‑b]吡嗪‑2‑基)氨基甲酸叔丁酯的制备方法,该制备方法以吡嗪‑2,5‑二胺为起始原料,经过一系列反应制得(5‑甲苯磺酰基‑5H‑吡咯并[2,3‑b]吡嗪‑2‑基)氨基甲酸叔丁酯,优化了合成路线,反应条件温和可控,操作和后处理简单方便,且产品收率提高,能够节约生产成本和时间,适合大规模工业化生产.

专利信息

专利号:US-11976077-B2
优先权日:2015-10-16
标 题 :Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-α]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms therof
发明人：PANGAN AILEEN L; TEIXEIRA HENRIQUE D; MOHAMED MOHAMED-ESLAM F; OTHMAN AHMED A; KLÃœNDER BEN; VOSS JEFFREY W; PADLEY ROBERT J; CAMP HEIDI S
权利人:ABBVIE INC
摘要:The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

专利号:US-9963459-B1
优先权日:2015-10-16
标 题:Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-alpla]pyrrolo[2,3-e]-pyrazin-8-YL)-N-(2,2,2-Trifluoroethyl)pyrrol and solid state forms thereof
发明人：JAYANTH JAYANTHY; MARROUM PATRICK J; MAYER PETER T; MOHAMED MOHAMED-ESLAM F; OTHMAN AHMED A
权利人:ABBVIE INC
摘要:The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.