CAS: 938-09-0; (2-Chloroethylsulfonyl)Benzene

该化合物是一种有机化合物,其特征是附于苯环的磺酰集团存在,并配有氯乙基替代成分,这种化合物一般视其特定形式和纯度而呈现无色的黄色液体或固体,以其色素或固体为典型,以其反应性而著称,特别是由于存在可参与核生殖替代反应的氯乙基集团. 磺酰集团加强了化合物的电生殖性,使其在各种化学合成中有用,包括制药和农用化学品生产.此外,它可能表现出中度至高毒性,需要谨慎处理和使用期间的适当安全措施.它存在于有机溶剂中的溶解性和水溶性有限,也具有显著的特征,影响其在化学工艺中的应用.

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合成工艺路线路线简述

  • 5535-49-9 = 938-09-0
    反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Tungsten Oxide (Wo3) Solvents: Methanol,Water; 5 Min,0 °C; 12 H,60 °C
    标题:Wo3 Nanoparticles On Mcm-48 As A Highly Selective And Versatile Heterogeneous Catalyst For The Oxidation Of Olefins,Sulfides,And Cyclic Ketones
    作者:Koo,Dong Hyun; Kim,Min; Chang,Sukbok
    参考文献:Organic Letters 日期:2005 卷标:7(22) 页码:5015-5018]

    5535-49-9 = 938-09-0
    反应条件:1.1 Reagents: Sulfuric Acid,Hydrogen Peroxide Solvents: Acetic Acid,Water; 12 S,105 °C
    标题:Process For Preparation Of Sulfoxide Or Sulfone By Oxidation Of Thioether In Microchannel Reactor
    参考文献:China]

    = 938-09-0
    反应条件:1.1 Catalysts: Tetrabutylammonium Tetrafluoroborate Solvents: Water; 16 H
    标题:Preparation Of Sulfinpyrazone
    参考文献:World Intellectual Property Organization]

    5535-49-9 = 938-09-0
    反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Tungstate(8-),(Aquadizincate)Tetracosa-μ-Oxotetra-μ4-Oxoundecaoxoundeca-,Ammon... Solvents: Water; 4 H,353 K
    标题:A Water Soluble Heteropolyoxotungstate As A Selective,Efficient And Environment Friendly Oxidation Catalyst
    作者:Maity,Prasenjit; Mukesh,Double; Bhaduri,Sumit; Lahiri,Goutam Kumar
    参考文献:Journal Of Chemical Sciences (Bangalore 日期:2009 卷标:121(4) 页码:377-385]

    = 938-09-0
    反应条件:1.1 Reagents: Potassium Carbonate Solvents: Dimethylformamide; 3 - 4 H,50 - 60 °C1.2 Reagents: Hydrogen Peroxide Solvents: Formic Acid,Water; 12 H,25 °C
    标题:Synthesis And Pharmacological Properties Of Benzamide Derivatives As Selective Serotonin 4 Receptor Agonists
    作者:Sonda,Shuji; Katayama,Kenichi; Kawahara,Toshio; Sato,Noriko; Asano,Kiyoshi
    参考文献:Bioorganic & Medicinal Chemistry 日期:2004 卷标:12(10) 页码:2737-2747]

    5535-49-9 = 938-09-0
    反应条件:1.1 Reagents: Chromium Trioxide
    标题:The Chlorosulfonyl Moiety As A Leaving Group: Hydride Reduction Of Sulfonyl Chlorides
    作者:Fong,Harvey Owen; Hardstaff,William Rayne; Kay,Denis George; Langler,Richard Francis; Morse,Richard Herman; Et Al
    参考文献:Canadian Journal Of Chemistry 日期:1979 卷标:57(10) 页码:1206-13]

    5535-49-9 = 938-09-0
    反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Acetic Acid
    标题:Neighboring Group Participation In The Conversion Of β-Substituted Ethanesulfonate Salts To β-Substituted Ethanesulfonyl Chlorides
    作者:Mcmanus,Samuel P.; Smith,Maurice R.; Herrmann,Frederick T.; Abramovitch,Rudolph A.
    参考文献:Journal Of Organic Chemistry 日期:1978 卷标:43(4) 页码:647-9]

    = 938-09-0
    反应条件:1.1 Solvents: Acetonitrile,Dichloromethane
    标题:Chlorine-Activation By Redox-Transfer. Iv. The Addition Of Sulfonyl Chlorides To Vinyl Monomers And Other Olefins
    作者:Asscher,M.; Vofsi,D.
    参考文献:Journal Of The Chemical Society 日期:1964 卷标:4962 页码:4962-71]

    5535-49-9 = 938-09-0
    反应条件:1.1 Reagents: Peracetic Acid Solvents: Acetic Acid,Chloroform
    标题:An Economical And Convenient Synthesis Of Phenyl Vinyl Sulfone From Benzenethiol And 1,2-Dichloroethane
    作者:Brace,Neal O.
    参考文献:Journal Of Organic Chemistry 日期:1993 卷标:58(16) 页码:4506-8]

    5535-49-9 = 938-09-0
    反应条件:1.1 Solvents: Acetic Acid1.2 Reagents: Hydrogen Peroxide Solvents: Water1.3 Reagents: Sodium Sulfite Solvents: Water
    标题:A New Synthetic Route For The Preparation Of Unsymmetrical Sulfides And 3-Alkyl-2-Arylthiophenes By The Use Of Bis[2-(Phenylsulfonyl)Ethyl] Sulfide
    作者:Hatayama,Atsushi; Kawakami,Hideo; Ohkubo,Kenji; Kumamoto,Takanobu
    参考文献:Proceedings Of The School Of Science Of Tokai University 日期:2000 卷标:35 页码:65-80]

    5535-49-9 = 938-09-0
    反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Benzeneseleninic Acid,Aluminum Nitrate Solvents: Ethanol; 2 H,40 °C
    标题:Phse(O)Oh/al(No3)3-Catalyzed Selectivity Controllable Oxidation Of Sulphide Owing To The Synergistic Effect Of Se,Al3+ And Nitrate
    作者:Zhang,Xu; Zhou,Rui; Qi,Zhengyuan; Chen,Liping; Yu,Lei
    参考文献:Reaction Chemistry & Engineering 日期:2022 卷标:7(9) 页码:1990-1996]

    5535-49-9 = 938-09-0
    反应条件:1.1 Reagents: Sulfuric Acid,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Acetonitrile,Water; 0 °C; 17 H,0 °C1.2 Reagents: Sodium Bisulfite Solvents: Water
    标题:Oxidative Neutralization Of Mustard-Gas Simulants In An On-Board Flow Device With In-Line Nmr Monitoring
    作者:Picard,Baptiste; Gouilleux,Boris; Lebleu,Thomas; Maddaluno,Jacques; Chataigner,Isabelle; Et Al
    参考文献:Angewandte Chemie 日期:2017 卷标:56(26) 页码:7568-7572]

    10154-71-9 = 938-09-0
    反应条件:1.1 Reagents: 1,2-Dichloroethane,2,6-Lutidine,Iodobenzene Diacetate Catalysts: 2,4,5,6-Tetra(9H-Carbazol-9-Yl)Isophthalonitrile; 16 H,25 °C
    标题:Sustainable Photoinduced Decarboxylative Chlorination Mediated By Halogen Atom Transfer
    作者:Levitre,Guillaume; Granados,Albert; Molander,Gary A.
    参考文献:Green Chemistry 日期:2023 卷标:25(2) 页码:560-565]

    5535-49-9 = 938-09-0
    反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Manganese(2+),(Hexahydro-α1,α4,α7-Trimethyl-1H-1,4,7-Triazonine-1,4,7-Triethano... Solvents: Acetonitrile,Water; 2 H,40 °C
    标题:Sulfide Oxidation With H2O2 Catalyzed By Manganese Complex Of N,N',N''-Tris(2-Hydroxypropyl)-1,4,7-Triazacyclononane
    作者:Feng,Xi-Mei; Wang,Zhen; Bian,Ning-Sheng; Wang,Zhi-Lin
    参考文献:Inorganica Chimica Acta 日期:2007 卷标:360(15) 页码:4103-4110]

    5535-49-9 = 938-09-0
    反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: 1,8-Diazabicyclo[5.4.0]Undec-7-Ene,Zinc Chloride Solvents: Methanol; Rt; 10 H,80 °C
    标题:The First Zinc-Catalyzed Oxidation Of Sulfides To Sulfones Using H2O2 As Green Oxidant
    作者:Feng,Jian-Bo; Gong,Jin-Long; Wu,Xiao-Feng
    参考文献:Rsc Advances 日期:2014 卷标:4(55) 页码:29273-29275]

    5535-49-9 = 938-09-0
    反应条件:1.1 Reagents: Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4) Solvents: Water; 2 H
    标题:L-Gel Formulation And Decontamination Reaction Of Its Active Ingredient (Oxone) Against Mustard And Vx Nerve Agent Simulants
    作者:Farahipour,Mahdi; Fakhraian,Hossein; Mirzaei,Akbar; Hosseini,Morteza Ali
    参考文献:Phosphorus 日期:2011 卷标:186(12) 页码:2303-2310]

    5535-49-9 = 938-09-0 [标题:Reaction Conditions
    标题:Deuterium-Enriched Eletriptan
    参考文献:United States]

    5535-49-9 = 938-09-0
    反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Acetic Acid
    标题:2-Benzenesulfonylethanesulfinic Acid,2-(2-Thiophenesulfonyl)Ethanesulfinic Acid,And Related Thiols,Sulfides,Disulfides,Sulfoxides Sulfones
    作者:Etienne,Andre; Baills,Gerard; Lonchambon,Georges; Desmazieres,Bernard
    参考文献:Comptes Rendus Des Seances De L'Academie Des Sciences 日期:1979 卷标:288(19) 页码:493-6
📜2-(苯亚磺酰)乙醇置于磺酰氯体系中,化学反应生成 2-氯乙基苯基砜
参考文献:Neighboring Group Participation In The Halogenation Of Sulfoxides
标题:Neighboring Group Participation In The Halogenation Of Sulfoxides
摘要:Phs(O)(Ch₂)ₙch₂oh(N = 1-3) 在氯化亚砜氯在−78°或0°的氯化亚砜中反应,得到相应的phso₂(Ch₂)ₙch₂cl.有证据表明,环状烷氧氧代磺鎓盐是这些转化中间体.当n = 4时,只观测到对亚砜功能的α氯化.烷磺酰基羧酸phs(O)(Ch₂)ₙco₂h (N = 1-3) 和酰胺phs(O)(Ch₂)ₙconh₂ (N = 1-3) 也与so₂cl₂反应.当n = 1或3时,两种化合物均观测到α氯化.当n = 2时,产物分别为3-苯基磺酰基丙酰氯和3-苯基磺酰基丙腈.
DOI:10.1139/v73-256

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摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 340.
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