CAS: 89488-30-2; 5-Bromo-3-Methylpyridin-2(1H)-One

相似化合物

17282-02-9 848365-77-5 1383847-34-4

上下游产品

5-bromo-3-methyl-pyridin-2-ylamine 5-bromo-2-chloro-3-methylpyridine 5-(3-Amino-4-fluoro-1-(3-(5-(prop-1-ynyl)pyridin-3-yl)phenyl)-1H-isoindol-1-yl)-1,3-dimethylpyridin-2(1H)-one (R)-5-(3-amino-4-fluoro-1-(3-(4-fluoro-5-methylpyridin-3-yl)phenyl)-1H-isoindol-1-yl)-1-ethyl-3-methylpyridin-2(1H)-one 5-(3-(3-Amino-4-fluoro-1-(1-isopropyl-5-methyl-6-oxo-1,6-dihydropyridin-3-yl)-1H-isoindol-1-yl)phenyl)nicotinonitrile

2-氨基-3-甲基-5-溴吡啶置于sodium Nitrite体系中,用 二氯甲烷,硫酸,水 作为反应溶剂,以84%的收率获得产物2-羟基-3-甲基-5-溴吡啶
参考文献:Diazabicyclic Central Nervous System Active Agents
标题:Diazabicyclic Central Nervous System Active Agents
摘要:式i1的化合物,这些化合物的药物组合物,以及利用这些组合物来控制哺乳动物的突触传递.

专利信息

专利号:WO-2025128873-A1
优先权日:2023-12-12
标题:Heterocyclic pyridinone compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

专利号:CN-101511852-B
优先权日:2006-06-30
标 题:Synthesis of diethyl { [5'' (3-fluorophenyl) -pyridin-2-yl ] methyl } phosphonate used in the synthesis of Himbacine analogs

专利号:CN-101511852-A
优先权日:2006-06-30
标题 :Synthesis of {[5″(3-fluorophenyl)-pyridin-2-yl]methyl}phosphonic acid diethyl ester used in the synthesis of Himbacine analogues

专利号:CN-118724798-A
优先权日:2024-07-18
标题 :Efficient synthesis method of (Z) -N-alkenyl-2-pyridone compound