CAS: 865362-74-9; 5-(2-Phenylpyrazolo[1,5-A]Pyridin-3-yl)-1H-Pyrazolo[3,4-C]Pyridazin-3-Amine

该化合物是一个化学化合物,在医学化学领域,特别是其潜在的治疗用途方面引起了关注,被定性为某些蛋白异体的选择性抑制剂,在细胞生长,分化和新陈代谢等各种细胞过程中发挥着关键作用;该化合物与目标有具体关联,成为了解与血管有关的途径及其对癌症等疾病的影响的研究的宝贵工具;就其物理特性而言,FR180204通常被描述为在室内温度下是固体,具有有机溶剂的溶解性;其分子结构包括有助于其生物活动和选择性的功能组;与许多实验化合物一样,有必要进一步研究,以充分阐明其药用近因,毒性和临床环境中的潜在治疗功效;

结构式图片

物理性质

MSDS等安全信息

欧盟法规

C&L通报

合成工艺路线路线简述

  • 1196794-13-4 = 865362-74-9
    反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; 3 H,Reflux; 2.5 D,Rt
    标题:Multi-Gram Scale Synthesis Of Fr180204
    作者:Patnaik,Samarjit; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2009 卷标:74(22) 页码:8870-8873]

    195826-99-4 = 865362-74-9
    反应条件:1.1 Reagents: 4-Methylmorpholine Solvents: 1,2-Dimethoxyethane; 5 Min,0 °C1.2 Reagents: Isobutyl Chloroformate; 4 H,Rt1.3 Reagents: Ammonium Hydroxide Solvents: Water; 16 H,Rt2.1 Reagents: Phosphorus Oxychloride; 1 H,Reflux3.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; 3 H,Reflux; 2.5 D,Rt
    标题:Multi-Gram Scale Synthesis Of Fr180204
    作者:Patnaik,Samarjit; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2009 卷标:74(22) 页码:8870-8873]

    195827-04-4 = 865362-74-9
    反应条件:1.1 Reagents: Phosphorus Oxychloride; 1 H,Reflux2.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; 3 H,Reflux; 2.5 D,Rt
    标题:Multi-Gram Scale Synthesis Of Fr180204
    作者:Patnaik,Samarjit; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2009 卷标:74(22) 页码:8870-8873]

    = 865362-74-9
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 16 H,Reflux2.1 Reagents: 4-Methylmorpholine Solvents: 1,2-Dimethoxyethane; 5 Min,0 °C2.2 Reagents: Isobutyl Chloroformate; 4 H,Rt2.3 Reagents: Ammonium Hydroxide Solvents: Water; 16 H,Rt3.1 Reagents: Phosphorus Oxychloride; 1 H,Reflux4.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; 3 H,Reflux; 2.5 D,Rt
    标题:Multi-Gram Scale Synthesis Of Fr180204
    作者:Patnaik,Samarjit; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2009 卷标:74(22) 页码:8870-8873]

    122643-81-6 + 609-09-6 = 865362-74-9
    反应条件:1.1 2 H,200 °C1.2 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; Overnight,Reflux2.1 Reagents: Hydrochloric Acid Solvents: Water; 16 H,Reflux3.1 Reagents: 4-Methylmorpholine Solvents: 1,2-Dimethoxyethane; 5 Min,0 °C3.2 Reagents: Isobutyl Chloroformate; 4 H,Rt3.3 Reagents: Ammonium Hydroxide Solvents: Water; 16 H,Rt4.1 Reagents: Phosphorus Oxychloride; 1 H,Reflux5.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; 3 H,Reflux; 2.5 D,Rt
    标题:Multi-Gram Scale Synthesis Of Fr180204
    作者:Patnaik,Samarjit; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2009 卷标:74(22) 页码:8870-8873]

    6295-87-0 + 1817-57-8 = 865362-74-9
    反应条件:1.1 Reagents: Potassium Carbonate,Potassium Hydroxide Solvents: Dimethyl Sulfoxide; 3 H,Rt2.1 2 H,200 °C2.2 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; Overnight,Reflux3.1 Reagents: Hydrochloric Acid Solvents: Water; 16 H,Reflux4.1 Reagents: 4-Methylmorpholine Solvents: 1,2-Dimethoxyethane; 5 Min,0 °C4.2 Reagents: Isobutyl Chloroformate; 4 H,Rt4.3 Reagents: Ammonium Hydroxide Solvents: Water; 16 H,Rt5.1 Reagents: Phosphorus Oxychloride; 1 H,Reflux6.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol; 3 H,Reflux; 2.5 D,Rt
    标题:Multi-Gram Scale Synthesis Of Fr180204
    作者:Patnaik,Samarjit; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2009 卷标:74(22) 页码:8870-8873
📜3-Chloro-6-(2-Phenylpyrazolo[1,5-A]Pyridin-3-yl)-4-Pyridazinecarbonitrile置于一水合肼体系中,用 乙醇 作为反应溶剂,以84%的收率获得产物fr180204,一种atp-竞争性的选择性的erk抑制剂
参考文献:Multi-Gram Scale Synthesis Of Fr180204
标题:Multi-Gram Scale Synthesis Of Fr180204
摘要:A Concise Synthesis Of The Erk Inhibitor Fr180204 Has Been Developed. The Synthesis Consists Of Six Operationally Simple Steps And Can Be Utilized To Make Multi-Gram Quantities Of Fr180204.
DOI:10.1021/jo901835M

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1: Shao N, Lu Q, Ouyang Z, Yang P, Wei T, Wang J, Cai B. Ganoderic acid a alleviates Aβ25-35-induced HT22 cell apoptosis through the ERK/MAPK pathway: a system pharmacology and in vitro experimental validation. Metab Brain Dis. 2024 Dec 3;40(1):51. doi: 10.1007/s11011-024-01429-1.
51:102206. doi: 10.1016/j.tranon.2024.102206. Epub 2024 Nov 27.
3: Zhang F, Cui X, Yang K, Guo R, Zhu L, Zhao W, Liu Z, Liu B. Activin A inhibits the migration of human lung adenocarcinoma A549 cells induced by EGF. Int Immunopharmacol. 2024 Dec 5;142(Pt B):113170. doi: 10.1016/j.intimp.2024.113170. Epub 2024 Sep 16. 76(12):1295-1308. doi: 10.1002/iub.2910. Epub 2024 Sep 12. 22(1):392. doi: 10.1186/s12964-024-01775-8.

合成参考文献


参考文献:10.1016/j.brainresbull.2018.04.013
摘要:Mardani P, Oryan S, Sarihi A, Komaki A, Shojaei A, Dehghan S, Mirnajafi-Zadeh J. ERK activation is required for the antiepileptogenic effect of low frequency electrical stimulation in kindled rats. Brain Res Bull. 2018 Jun;140():132–9. doi: 10.1016/j.brainresbull.2018.04.013.
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