A-乙酰环戊烷乙酸乙酯置于乙醇,Sodium体系中,化学反应生成 2-环戊基乙醇 参考文献:über Die Bedeutung Zyklischer Säuren Und Alkohole Für Die Chemotherapie Der Lepra. Ii. Mitteilung 标题:über Die Bedeutung Zyklischer Säuren Und Alkohole Für Die Chemotherapie Der Lepra. Ii. Mitteilung 摘要: DOI:10.1002/ardp.19432811004
专利号:WO-0120995-A9 优先权日:1999-09-23 标题:Compounds directed against pilus biogenesis and activity in pathogenic bacteria; methods and compositions for synthesis thereof 发明人:KIHLBERG JAN; LARSSON ANDREAS; SVENSSON ANETTE; FEX TOMAS; HULTGREN SCOTT J; PINKNER JERRY 权利人:UNIV WASHINGTON; KIHLBERG JAN; LARSSON ANDREAS; SVENSSON ANETTE; FEX TOMAS; HULTGREN SCOTT J; PINKNER JERRY 摘要:Many Gram-negative pathogens assemble adhesive structures on their surfaces that allow them to colonize host tissues and cause disease. Novel compositions which inhibit or prevent the formation of a pilus chaperone-subunit complex are disclosed. Interfering with the function of the pili chaperone negatively affects the chaperone/usher pathway which is one molecular mechanism by which Gram-negative bacteria assemble adhesive pili structures and thus prevent or inhibit pilus assembly. Also provided are methods for the treatment or prevention of diseases caused by tissue-adhering pilus-forming bacteria by inhibiting the function of pilus chaperones. Also provided are pharmaceutical preparations capable of inhibiting or preventing the formation of a pilus chaperone-subunit complex. Also provided are methods of synthesizing the N-substituted amino acid compounds and compounds useful for the synthesis thereof. In particular, novel fluorinated linker compounds and methods of synthesis are provided. Methods for using the fluorinated linker compounds in methods of solid-phase synthesis of the N-substituted amino acid compounds are also disclosed.
专利号:WO-2011114184-A1 优先权日:2010-03-15 标题 :Amides of heterocyclic compounds as trpa1 inhibitors 发明人:CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; PATIL NISHA PARAG; KADAM ASHOK BHAUSAHEB; WAGHMARE NAYAN TATERAO; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL 权利人:GLENMARK PHARMACEUTICALS SA; CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; PATIL NISHA PARAG; KADAM ASHOK BHAUSAHEB; WAGHMARE NAYAN TATERAO; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL 摘要:Amides of heterocyclic compounds as Transient Receptor Potential subfamily A (TRPA) modulators are provided In particular, compounds described herein are useful for treating or preventing diseases, conditions and/ or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1) Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. (I).
专利号:US-9370515-B2 优先权日:2013-03-07 标题 :Mixed lineage kinase inhibitors and method of treatments 发明人:GOODFELLOW VAL S; NGUYEN THONG X; RAVULA SATHEESH B; GELBARD HARRIS A 权利人:CALIFIA BIO INC; UNIV ROCHESTER 摘要:Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their therapeutic. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and pharmaceutical compositions.
专利号:US-4592865-A 优先权日:1976-08-09 标 题 :Azetidinone intermediates for cephalosporin analogs 发明人:NARISADA MASAYUKI; ONOUE HIROSHI; TSUJI TERUJI; NISHITANI YASUHIRO; YOSHIOKA MITSURU; HAMASHIMA YOSHIO; NAGATA WATARU 权利人:SHIONOGI & CO 摘要:Intermediates of the following formula are useful for the synthesis of 1-oxacephalosporins. Their preparation from penicillins and the transformation process to make 1-oxacephalosporins are disclosed. The compounds are of the formula: wherein A is amino or a selected acylamino; COB is carboxy or a selected protected-carboxy; X is halogen or the group OR in which R is a group represented by following formulas: CH2CCH, CH2CCNu, CH2CHCH2, +TR wherein Nu is a selected nucleophilic group; R1 is a group of the following formula: in which Hal is halogen or alkylsulfonyloxy and R2 is alkyl or aryl; and Y is hydrogen or methoxy; with the proviso that when R is propargyl or 2-oxopropyl and R1 is A is in the 3 alpha -configuration and Y is 3 beta -hydrogen or A is in the 3 beta -configuration and Y is 3 alpha -methoxy.
专利号:US-6852752-B2 优先权日:1999-12-17 标 题:Urea compounds, compositions and methods of use and preparation 发明人:JACOBS JEFFREY W; PATEL DINESH; LEWIS JASON; NI ZHI-JIE 权利人:VICURON PHARM INC 摘要:Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.
专利号:EP-3650430-A1 优先权日:2015-05-12 标题 :Intermediates and processes for the synthesis of herbicides
参考文献:10.1055/s-0029-1217050 摘要:Mani N, Pandit C. Expedient Reductive Amination of Aldehyde Bisulfite Adducts. Synthesis. 2009 Nov 03;2009(23):4032–6. doi: 10.1055/s-0029-1217050. 参考文献:10.1007/s12355-025-01647-6 摘要:Li X, Lou H, Lu Z, Dong L, He L, Li F. A Metabolomic Study Reveals Substantial Genetic Variation in Volatile and Non-Volatile Compounds in Sugarcane Juice. Sugar Tech. 2025 Sep 15;28(1):141–50. doi: 10.1007/s12355-025-01647-6.