CAS: 7341-96-0; Propiolamide

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15430-52-1 2450-71-7 60-35-5

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CAS号922-67-8 甲基丙烯酸酯 | CAS号623-47-2 丙炔酸乙酯 | CAS号107-19-7 丙炔醇 | CAS号1070-71-9 丙炔腈 | CAS号4672-74-6 1-[1-(4,5-dimet... | CAS号53389-00-7 6-羟基吡啶-2-甲酸乙酯 | CAS号2807-36-5 Thi°Cyanic acid... | CAS号2807-37-6 Thi°Cyanic acid... | CAS号601514-58-3 6-苄基-5,6,7,8-四氢... | CAS号1070-71-9 丙炔腈 | CAS号14678-05-8 异恶唑-5-胺 | CAS号1750-42-1 3-氨基异噁唑 | CAS号63462-41-9 3-(4-methylphen...

📜丙炔酸乙酯置于氨体系中,用 水 作为反应溶剂,化学反应 1.0H,以52%的收率获得产物丙炔酰胺
参考文献:不饱和 1-酰基-1H-吡咯的 Stetter 反应
标题:不饱和 1-酰基-1H-吡咯的 Stetter 反应
摘要:α,β-不饱和 1-酰基-1H-吡咯用作使用有机催化 Stetter 反应构建 1,4-二羰基系统的使能单元.1-酰基-1H-吡咯单元增强的亲电性允许从脂肪醛催化构建稠合和非稠合吡喃酮,与芳香醛相容,并且还促进了涉及芳香醛和脂肪醛的反应的分子间变体.
DOI:10.1002/ejoc.201101151

专利信息

专利号:US-8058414-B2
优先权日:2008-04-29
标题 :Unnatural polymerase substrates that can sustain enzymatic synthesis of double stranded nucleic acids from a nucleic acid template and methods of use
发明人：MENCHEN STEVEN; ROSENBLUM BARNETT; KENNEY PAUL; KHAN SHOEB; MA ZHAOCHUN; CHEN JER-KANG; LAM JOE Y; HUANG BOLI
权利人:MENCHEN STEVEN; ROSENBLUM BARNETT; KENNEY PAUL; KHAN SHOEB; MA ZHAOCHUN; CHEN JER-KANG; LAM JOE Y; HUANG BOLI; LIFE TECHNOLOGIES CORP
摘要:Nucleotide analogs that can sustain the enzymatic synthesis of double-stranded nucleic acid from a nucleic template are described. The nucleotide analogs include: (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine, uracil and their analogs; (ii) a label attached to the base or analog of the base via a cleavable linker; (iii) a deoxyribose; and (iv) one or more phosphate groups. The linker and/or the label inhibits template directed polymerase incorporation of a further nucleotide substrate onto an extended primer strand. In addition, cleavage of the linker leaves a residue attached to the base which is not present in the natural nucleotide and which does not inhibit extension of the primer strand. The nucleotide analogs can therefore be used as reversible terminators in sequencing by synthesis methods without blocking the 3′ hydroxyl group. Methods of sequencing DNA using the substrates are also described.

专利号:WO-2022260545-A1
优先权日:2021-06-11
标题:Synthesis of a novel glucose-conjugated methotrexate and its application for the treatment and prevention of neoplasms
发明人：AGRAWAL SIDDARTH; WOŹNIAK MARTA; MAKUCH SEBASTIAN; Szeja WiesÅ‚aw; PASTUCH-GAWOÅ?EK GABRIELA; KRAWCZYK MONIKA; WiÅ›niewski Jerzy; GAMIAN ANDRZEJ; ZIÓÅ?KOWSKI PIOTR
权利人:UNIV MEDYCZNY IM PIASTOW SLASKICH WE WROCLAWIU
摘要:The subject of the invention is a new methotrexate-glucose conjugate derivative, its synthesis, and its use in the treatment and prevention of neoplasms, preferably in the treatment and prevention of neoplasms selected from: skin cancer, colorectal cancer, breast cancer, gastric cancer, sarcoma and lung cancer.

专利号:US-2024261416-A1
优先权日:2023-01-31
标题:Synthesis of novel cereblon e3 ligase ligands, compounds formed thereby, and pharmaceutical compositions containing them
发明人：TANG WEIPING; XIE HAIBO; WU YUNXIANG; LIAO JUNZHUO; LI CHUNRONG; TANDON IRA; TANG HUA
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Provided herein are achiral cereblon (CRBN) ligands based on phenyl dihydrouracil that have optimal binding to CRBN without having chiral carbons. Also provided herein are the proteolysis targeting chimeras (PROTACs) comprising the CRBN ligands and a protein binder, pharmaceutical compositions containing the PROTACs, and methods of treating diseases using the PROTACs.

专利号:US-9896473-B2
优先权日:2012-04-04
标 题:Thiol compounds and the use thereof for the synthesis of modified oligonucleotides
发明人：MORVAN FRANÇOIS; MEYER ALBERT; VASSEUR JEAN JACQUES; MAYEN JULIE; CHAIX CAROLE; FARRE CAROLE; FOURNIER WIRTH CHANTAL; CANTALOUBE Jean François; LEREAU MYRIAM
权利人:CENTRE NAT RECH SCIENT; UNIV DE MONTPELLIER 1; FRANCAIS DU SANG ETS; UNIV CLAUSE BERNARD LYON 1; FRANCAIS DU SANG ETS
摘要:The present invention relates to a thiol compound suitable for forming a chain of oligomers that can be grafted to an oligonucleotide. The invention also relates to an oligonucleotide grafted by such a compound, thus having one or more thiol functions, suitable for being immobilized on a gold surface or on a grafted surface.

专利号:US-4465845-A
优先权日:1982-04-26
标题:High pressure synthesis of sulfur-selenium fulvalenes
发明人：OKAMOTO YOSHIYUKI; WOJCIECHOWSKI PIOTR S
权利人:KOPPERS CO INC
摘要:A process is disclosed for one-step preparation of sulfur-selenium fulvalenes by reaction of an acetylenic compound with carbon selenide sulfide or with a mixture of carbon diselenide and carbon disulfide under pressures of at least about 1,000 atmospheres. Fulvalene compounds made by the process are characterized in having at least one sulfur atom and at least one selenium atom in the ring structure of the fulvalene compound. Substituted diselenadithiafulvalenes made by this process are precursors to very pure diselenadithiafulvalene which is useful in preparing charge-transfer salts.

专利号:US-12263177-B2
优先权日:2019-02-07
标题:Biologically active ganoderma lucidum compounds and synthesis of anticancer derivatives; ergosterol peroxide probes for cellular localization
发明人：MARTINEZ-MONTEMAYOR MICHELLE M; RIVAS FATIMA
权利人:UNIV CENTRAL DEL CARIBE; ST JUDE CHILDRENS RES HOSPITAL INC
摘要:The bioactive compounds of Ganoderma lucidum extract (GLE) responsible for anticancer activity were elucidated using NMR, X-ray crystallography and analogue derivatization, as well as anti-cancer activity studies. Structures of the seven most abundant GLE compounds are disclosed. Their selective efficacy against triple negative (TNBC) and inflammatory breast cancers (IBC) and other human cancer cell types (solid and blood malignancies) was shown, confirming potential their as anticancer agents.