CAS: 64218-02-6; Plaunotol

该化合物是作为胃保护剂,主要为化学化合物,来自自然来源,特别是植物物种*Plaonotol*,该物质具有治疗特性,具有白色至白粉等特性,在有机溶剂中溶解,但水溶解度有限;Plaonotol功能,对胃肌肉肌肉形成保护屏障,从而帮助预防胃溃疡和促进愈合;其行动机制包括加强肌肉防御,刺激肌肉和双碳酸盐的生产;此外,Plaonotol已经研究其潜在的抗炎作用;安全简介表明,它一般具有良好的营养,尽管它与任何制药剂一样,在临床使用中可能具有相反的副作用.

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合成工艺路线路线简述

    📜(E)-6,10-Dimethyl-2-[(E)-4-Methyl-6-(Tetrahydro-Pyran-2-Yloxy)-Hex-4-En-(Z)-Ylidene]-Undeca-5,9-Dien-1-Ol置于对甲苯磺酸体系中,用 甲醇 作为反应溶剂,以81%的收率获得产物谱劳诺托
    参考文献:Horner-Emmons反应z选择性形成三取代的α,β-不饱和腈
    标题:Horner-Emmons反应z选择性形成三取代的α,β-不饱和腈
    摘要:明确了允许磷腈的霍纳-埃蒙斯反应进行z选择性的条件.该方法的普遍性和实用性通过在立体选择性合成青草醇中的应用得到了证明(9).
    DOI:10.1016/s0040-4039(00)76763-3

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    专利信息


    专利号:US-8293290-B2
    优先权日:2003-04-08
    标题:Annatto extract compositions, including geranyl geraniols and methods of use
    发明人：TAN BARRIE
    权利人:TAN BARRIE; AMERICAN RIVER NUTRITION INC
    摘要:Annatto extract composition (AEC), including cis and trans geranyl geraniols (GG) and tocopherol-free C-5 unsubstituted tocotrienols (T3), increases the de novo synthesis of intermediate isoprenoid and distal protein products, including endogenous coenzyme Q10 (CoQ10), dolichols (DL) and all subsequent GG-prenylated and DL-glycosylated proteins, including GG-porphyrinated hemes. This intermediate and distal product replenishment by AEC reverses maladies of myotoxicity (of both drug and non-drug origins), including maladies that affect the muscle, kidney, eye, GI tract and skin, nerve, blood, and CoQ10-related syndromes of energetics and LDL protection. AEC anabolically increases the endogenous de novo CoQ10 synthesis via GG elongation/prenylation of side-chain and conversely CoQ10 catabolically increases the endogenous de novo GG synthesis via beta-oxidation of CoQ10. Also, such AEC decreases de novo synthesis and increases disposal of triglycerides (TG) in humans via PPAR activation and SREBP deactivation. Such drop in TG by AEC reverses maladies of insulin resistance (IR) and metabolic syndrome (MS), prediabetes, diabetes and diabetes-related cardiovascular diseases (CVD). GG activates PPAR and down regulates SREBP transcription factors. This AEC, containing GG, inhibits cancer growth whether or not GG involvement in protein prenylation is required.

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    主要参考文献


    1: Hokari A. [Improved virologic response in chronic hepatitis C treated with peginterferon, ribavirin and add-on drug]. Nihon Rinsho. 2011 May;69 Suppl
    4:196-200. Review. Japanese. Review. Japanese. Review. Japanese. Review.

    合成参考文献


    摘要:Stolley, R. M.; Louie, J., Science of Synthesis Knowledge Updates, (2013) 2, 20.
    摘要:Oyo Yakuri. Pharmacometrics., 24(599), 1982
    摘要:Matsumoto Y, Hamashima H, Masuda K, Shiojima K, Sasatsu M, Arai T. The antibacterial activity of plaunotol against Staphylococcus aureus isolated from the skin of patients with atopic dermatitis. Microbios. 1998;96(385):149–55.
    参考文献:10.1007/s10096-011-1287-x
    摘要:Ali F, Sangwan PL, Koul S, Pandey A, Bani S, Abdullah ST, Sharma PR, Kitchlu S, Khan IA. 4-epi-Pimaric acid: a phytomolecule as a potent antibacterial and anti-biofilm agent for oral cavity pathogens. European Journal of Clinical Microbiology & Infectious Diseases. 2011 May 19;31(2):149–59. doi: 10.1007/s10096-011-1287-x.
    参考文献:10.1007/bf02100139
    摘要:Xu G, Sumi S, Koike M, Tanigawa K, Nio Y, Tamura K. Role of endogenous hypergastrinemia in regenerating endocrine pancreas after partial pancreatectomy. Digestive Diseases and Sciences. 1996 Dec;41(12):2433–9. doi: 10.1007/bf02100139.
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