📜百里酚置于盐酸体系中,用 乙酸乙酯 作为反应溶剂,化学反应生成 2-羟基-3-异丙基-6-甲基苯甲酸 参考文献:Substituent Modification In Tri-O-Thymotide And Its Effects On Host Geometry And Guest Enclathration .1. Synthesis 标题:Substituent Modification In Tri-O-Thymotide And Its Effects On Host Geometry And Guest Enclathration .1. Synthesis 摘要: DOI:10.1016/s0040-4020(01)90268-6
专利号:US-9453037-B2 优先权日:2011-07-28 标 题 :Methylphenidate-prodrugs, processes of making and using the same 发明人:GUENTHER SVEN; CHI GUOCHEN; BERA BINDU; MICKLE TRAVIS; BERA SANJIB 权利人:KEMPHARM INC; KEMPHARM INC 摘要:The present technology is directed to prodrugs and compositions for the treatment of various diseases and/or disorders comprising methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof. In some embodiments, the conjugates further include at least one linker. The present technology also relates to the synthesis of methylphenidate, or methylphenidate derivatives, conjugated to at least one alcohol, amine, oxoacid, thiol, or derivatives thereof or combinations thereof.
专利号:US-9217012-B2 优先权日:2009-04-08 标题 :Inhibitors of protein tyrosine phosphatases 发明人:ZHANG ZHONG-YIN; ZHANG SHENG 权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP 摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
[参考文献]: F J Marozzi, Et Al. Analgesic And Anti-Inflammatory Evaluation Of Thymotic Acid And Certain Homologs. J Pharm Sci. 1968 Jun;57(6):989-94.
合成参考文献
摘要:Farmaco, Edizione Scientifica., 20(506), 1965 [] 摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198 参考文献:10.1002/jps.3030430710 摘要:Granatek E, Jannke P. Dehydration Products of o-Thymotic Acid*. Journal of the American Pharmaceutical Association (Scientific ed.). 1954 Jul;43(7):421–2. doi: 10.1002/jps.3030430710.