CAS: 52200-99-4; 2-Fluorobenzenesulfonyl Fluoride
该化合物是一种含分子式C6H4FSO2F的氟化芳烃氟化物化合物.它是有机合成的多用途中间体,特别是在编制磺酰胺和其他含有磺酰氟的衍生物时.氟和氟化烃组的存在增强了其反应性,使其对医药化学和材料科学的选择性转变具有价值.在各种条件下,其稳定性允许有控制的功能化,而氟替代成分的电子提取性质可以影响反应途径.这种化合物通常用于交叉反应和作为药物和农用化学的建筑块.
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号2905-21-7 2-氟苯磺酰氯 | CAS号115560-96-8 1,2-benzenedisu... | CAS号6461-76-3 1,2-苯二磺酰二氯 | CAS号2358-41-0 1-氟-2-(三氟甲磺酰基)苯合成工艺路线路线简述
- 合成目标产物 2-Fluorobenzenesulfonyl Fluoride 主要起始原料 2-Fluorobenzenesulfonyl Chloride
- (文献来源)合成步骤主要原料 2-Fluorobenzenesulfonyl Chloride
📜1,2-苯二磺酰二氯置于potassium Fluoride,二苯并-18-冠醚-6体系中,用 环丁砜,乙腈 作为反应溶剂,化学反应 1.25H,反应生成 2-氟苯磺酰氯
参考文献:Potassium Fluoride Catalyzed Fluorodesulfonylations Of Aryl Sulfonyl Fluorides
标题:Potassium Fluoride Catalyzed Fluorodesulfonylations Of Aryl Sulfonyl Fluorides
摘要:
DOI:10.1021/jo00253A040
专利信息
专利号:US-2025188046-A1
优先权日:2023-12-08
标题:Ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent sufex connections via lithiated chemistry
发明人：KIM DONG-PYO; KANG JI-HO
权利人:POSTECH RES & BUSINESS DEV FOUND
摘要:Disclosed are ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent SuFEx connections via lithiated chemistry. In detail, a method of synthesizing an ortho-functionalized benzenesulfonyl fluoride derivative, the method comprises (a) reacting a benzenesulfonyl fluoride derivative represented by structural formula 1 with an organolithium represented by structural formula 2, thus synthesizing an intermediate represented by structural formula 3 in reaction scheme 1 and (b) reacting the intermediate with an electrophile, thus synthesizing a compound represented by structural formula 4 or a compound represented by structural formula 4′. The present disclosure enables the synthesis of several functionalized sulfonyl fluorides within a few seconds under mild temperature conditions in addition to the chemistry of Sulfonyl Fluoride Exchange (SuFEx), which is a next-generation click chemistry, so that sulfonyl fluoride, the main reactant of the SuFEx reaction, can be efficiently secured.
专利号:CN-108203408-A
优先权日:2018-03-12
标题:A kind of pyrazole compound containing N-arylsulfonate and its synthesis and application
