CAS: 38469-83-9; 4-Methoxy-2-Nitrobenzonitrile

上下游产品

sodium cyanide 4-methoxy-2-nitroaniline potassium cyanide 2-Nitroanisole 2-nitro-4-methoxybenzoic acid 4-methoxy-2-nitro-benzoic acid amide 2-amino-p-anisamide 4-methoxyanthranilonitrile

1,4-二氟苯置于硫酸,氨,Potassium Nitrate,Sodium Nitrite体系中,用 水,二甲基亚砜,N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 4-甲氧基-2-硝基苯腈
参考文献:一种2-硝基-4-甲氧基苯甲酸的制备方法
标题:一种2-硝基-4-甲氧基苯甲酸的制备方法
摘要:本发明公开了一种2‑硝基‑4‑甲氧基苯甲酸的工业化制备方法.该2‑硝基‑4‑甲氧基苯甲酸的工业化制备方法,以对二氟苯为初始原料,经硝化,氨解,重氮上溴,氰化,甲氧基化以及水解六步反应合成2‑硝基‑4‑甲氧基苯甲酸.本过程得到的2‑硝基‑4‑甲氧基苯甲酸为白色粉末状固体,纯度98.5%,每步原料转化率分别达到100%,整个过程的总收率达到35.8%.

专利信息

专利号:WO-2016122325-A1
优先权日:2015-01-30
标 题:Methods for providing intermediates in the synthesis of atorvastatin.
发明人：DÖMLING ALEXANDER STEPHAN SIEGFRIED
权利人:UNIV GRONINGEN
摘要:The invention relates to the field of medicinal chemistry, In particular, it relates to methods for providing intermediates in the synthesis of Atorvastatin, a competitive inhibitor of HMG-Co A reductase. Provided is a process for providing a compound having a Formula (I) or a pharmaceutically acceptable salt, ester, amide or stereoisomer thereof, comprising reacting in a 4 component Ugi-reaction in a single reaction mixture the compounds of formula A, formula B, formula C and formula D.