CAS: 3496-11-5; (S)-2,5-Dioxopyrrolidin-1-Yl 2-(((Benzyloxy)Carbonyl)Amino)-3-Methylbutanoate

相似化合物

4467-55-4 130878-68-1 3392-12-9

上下游产品

1-hydroxy-pyrrolidine-2,5-dione (S)-N-(benzyloxycarbonyl)valine N,N'-disuccinimidyl oxalate Isopropenyl Succinimido Carbonatemethyl (S)-2-((S)-2-benzyloxycarbonyl-amino-3-methylbutyrylamino)-3-methylbutyrate N-benzyloxycarbonylvalylglycine methyl ester (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanamido)-4-methylpentanoate N-(N-benzyloxycarbonyl-L-valyl)-L-tyrosine methyl esterN-(N-benzyloxycarbonyl-L-valyl)-L-tyrosine methyl ester

📜L-缬氨酸盐酸盐置于sodium Carbonate,N,N'-二环己基碳二亚胺体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 32.0H,反应生成 N-苄氧羰基-L-缬氨酸琥珀酰亚胺酯
参考文献: Peptidomimetic Compounds And Antibody-Drug Conjugates Thereof[fr] Composés Peptidomimétiques Et Conjugués Anticorps-Médicament De Ceux-Ci
标题: Peptidomimetic Compounds And Antibody-Drug Conjugates Thereof[fr] Composés Peptidomimétiques Et Conjugués Anticorps-Médicament De Ceux-Ci

专利信息

专利号:US-4504415-A
优先权日:1983-04-04
标题:Synthesis of thymosin α1 and desacetyl thymosin α1
发明人：FELIX ARTHUR M; GILLESSEN DIETER; STUDER ROLF; MEIENHOFER JOHANNES A; TRZECIAK ARNOLD
权利人:HOFFMANN LA ROCHE
摘要:An improved solution phase synthesis of thymosin alpha 1 and desacetyl thymosin alpha 1 with t-Boc side chain protection and proceeding through novel intermediates is disclosed.

专利号:US-3795666-A
优先权日:1969-08-01
标 题 :Method of synthesizing peptides in the presence of a carbodiimide and of 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine
发明人：KONIG W; GEIGER R; WOLF E
权利人:HOECHST AG
摘要:IMPROVED SYNTHESIS OF PEPTIDES BY THE CARBODIIMIDE METHOD IN WHICH AN AMINO-PROTECTED AMINO ACID OR PEPTIDE HAVING A REACTIVE CARBOXY GROUP IS CONDENSED WITH A CARBOXY-PROTECTED AMINO ACID OR PEPTIDE HAVING A REACTIVE AMINO IN THE PRESENCE OF 3-HYDROXY-4-OXO3,4-DIHYDRO-1,2,3-BENZOTRIAZINE AS WELL AS IN THE PRESENCE OF A CARBODIIMIDE SUCH AS DICYCLOHEXYL CARBODIIMIDE.

专利号:WO-0071569-A1
优先权日:1999-05-26
标题 :Minimal isolation peptide synthesis process using ion-exchange resins as scavenging agents
发明人：TOLLE JOHN C; CALIFANO JEAN-CHRISTOPHE; DHAON MADHUP K; SACHS HOWARD A; BLODGETT JAMES K
权利人:ABBOTT LAB
摘要:A process for the production of a polypeptide having a pre-determined number and sequence of amino acid residues, comprising the steps of first exposing a first substrate amino acid or peptide fragment to a stoichiometric excess of a second reactant amino acid or peptide fragment to form a condensation product; second, contacting the reaction solution from the first step with an insoluble scavenger to sequester the excess of the second reactant amino acid or peptide fragment; third, removing from the solution the sequestered excess second reactant amino acid or peptide fragment; fourth, subjecting the reaction solution to a reaction which removes the protecting group from either the N- or C-terminus of the condensation product of the first step; and fifth, if necessary, repeating the first through fourth steps. The method is capable of large-scale production of peptides in solution, is not subject to the one-terminus-only limitation of the solid-phase method, possesses the 'cleanliness' of the solid-phase method and, like the solid-phase method, is capable of automation. Most importantly, however, the method of the present invention does not require the frequent isolation of intermediates in a lengthy synthetic sequence nor, necessarily, the removal of all contaminating by-products from the reaction mixture prior to subsequent processing steps.

专利号:US-5491149-A
优先权日:1991-09-16
标题 :Dihydroxypropylamine containing retroviral protease inhibitors
发明人：JADHAV PRABHAKAR K
权利人:DU PONT MERCK PHARMA
摘要:This invention relates to substituted dihydroxypropylamines, a process to prepare intermediates useful for the synthesis of these compounds, compositions comprising such compounds, and a method of treating retroviral infection.

专利号:RU-2175973-C1
优先权日:2000-08-10
标 题:Method of synthesis of tetradecapeptide

专利号:MX-PA01012082-A
优先权日:1999-05-26
标 题 :SYNTHESIS PROCESS OF MINIMUM INSULATION PEPTIDES, USING ION EXCHANGE RESINS AS CLEANING AGENTS.