CAS: 269409-70-3; 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenol

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CAS号106-41-2 对溴苯酚 | CAS号73183-34-3 双戊酰二硼 | CAS号540-38-5 4-碘苯酚 | CAS号25015-63-8 频那醇硼烷 | CAS号106-48-9 对氯苯酚 | CAS号76-09-5 频哪醇 | CAS号71597-85-8 4-羟基苯硼酸 | CAS号480438-75-3 4-(叔丁氧羰氧基)苯硼酸频哪醇酯 | CAS号123-30-8 对氨基苯酚 | CAS号17878-44-3 对(三甲基硅氧基)溴苯 | CAS号3916-44-7 4-羟基-4'-硝基联苯 | CAS号957061-13-1 2-(4-(3-溴丙氧基)苯基... | CAS号28034-99-3 4-氯-4'-羟基联苯 | CAS号81267-65-4 脱氢雌马酚 | CAS号873078-93-4 4-(2-(二甲基氨基)乙氧基... | CAS号95-56-7 2-溴苯酚 | CAS号71597-85-8 4-羟基苯硼酸 | CAS号608-33-3 2,6-二溴苯酚 | CAS号16881-71-3 4-羟基-4'-甲氧基联苯 | CAS号269410-28-8 4-乙氧基羰基甲氧基苯硼酸

4-(甲硫基)苯酚置于吡啶体系中,用 水,1,2-二氯乙烷,丙酮 用作溶剂,化学反应 24.0H,反应生成4-羟基苯硼酸频哪醇酯
参考文献:通过光激活的cs活化,芳基s盐的氧化还原中性硼化反应.
标题:通过光激活的cs活化,芳基s盐的氧化还原中性硼化反应.
摘要:本文报道了一种使用双(频哪醇)二硼作为硼源进行芳基sulf盐的硼化的新光诱导策略.该方法利用氧化还原中性芳基sulf在无过渡金属条件下进行光激发时通过cs键活化来获得芳基自由基.因此,它可从容易获得的芳基sulf获得具有非常好性能的各种芳基硼酸酯,并伴有温和的条件,操作简便和易于扩展.
Doi:10.1021/acs.Orglett.9B03850

专利信息

专利号:EP-4186890-A1
优先权日:2021-11-29
标题 :Preparation of n-benzyl-2-(5-bromo-pyridin-2-yl)-acetamide for the synthesis of tirbanibulin
发明人：ARE CELESTE; BALLETTE ROBERTO; DOBARRO RODRÃ?GUEZ ALICIA
权利人:MOEHS IBERICA SL
摘要:The present invention relates to a process for the preparation of N-benzyl-2-(5-bromo-pyridin-2-yl)-acetamide, which is a suitable intermediate for the synthesis of tirbanibulin or a pharmaceutically acceptable salt thereof, as well as to a process for the preparation of tirbanibulin or a pharmaceutically acceptable salt thereof using said N-benzyl-2-(5-bromo-pyridin-2-yl)-acetamide intermediate.

专利号:US-2024343691-A1
优先权日:2006-12-28
标题:Compositions for modulating a kinase cascade and methods of use thereof
发明人：HANGAUER JR DAVID G; PATRA DEBASIS; CODY JEREMY A; PALMER GRANT J; ISBESTER PAUL K; SALSBURY JONATHON
权利人:ATNX SPV LLC
摘要:The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl) pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure.

专利号:US-8293739-B2
优先权日:2006-12-28
标题:Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
发明人：HANGAUER JR DAVID G; COUGHLIN DANIEL; GALE JONATHAN; CODY JEREMY A; PATRA DEBASIS; PALMER GRANT J; ISBESTER PAUL K; SALSBURY JONATHON
权利人:HANGAUER JR DAVID G; COUGHLIN DANIEL; GALE JONATHAN; CODY JEREMY A; PATRA DEBASIS; PALMER GRANT J; ISBESTER PAUL K; SALSBURY JONATHON; KINEX PHARMACEUTICALS LLC
摘要:The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy) phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention.

专利号:US-12441733-B2
优先权日:2018-03-26
标题:Substituted 2,4-dioxotetrahydropyrimidines as intermediates in the synthesis of bruton's tyrosine kinase inhibitors
发明人：ARISTA LUCA; HEBACH CHRISTINA; HOLLINGWORTH GREGORY JOHN; HOLZER PHILIPP; IMBACH-WEESE PATRICIA; LORBER JULIEN; MACHAUER RAINER; SCHMIEDEBERG NIKO; VULPETTI ANNA; ZOLLER THOMAS
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formulae (I), (III), (IIIa), (XXIa), (XXIII), and/or (XLVI)or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

专利号:US-9556120-B2
优先权日:2006-12-28
标题:Compositions for modulating a kinase cascade and methods of use thereof
发明人：HANGAUER JR DAVID G; PATRA DEBASIS; CODY JEREMY A; PALMER GRANT J; ISBESTER PAUL K; SALSBURY JONATHON
权利人:ATHENEX INC
摘要:The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure.

专利号:WO-2023061999-A1
优先权日:2021-10-12
标 题 :Process for preparing a phenolic hydrocarbon
发明人：CORNELLA JOSEP; LE VAILLANT FRANCK
权利人:STUDIENGESELLSCHAFT KOHLE GGMBH
摘要:The present invention discloses a distinct mode of action of a nickel catalyst to forge C-0 bonds to unlock the mild utilization of N2O as O-atom transfer reagent in the synthesis of complex phenols from the corresponding aryl halides.