CAS: 2305-25-1; Ethyl 3-Hydroxyhexanoate

相似化合物

88496-71-3 3249-68-1 10191-24-9

上下游产品

butyraldehyde ethyl bromoacetate 1-ethoxyacetylene ethyl butyroyl acetateethyl 4-hydroxy-2-propyl-5-oxo-2,5-dihydrofuran-3-carboxylate 5-phosphanylidene)-°Ctanenitrile5-hydroxy-3-oxo-2-(triphenyl-λ5-phosphanylidene)-°Ctanenitrile 5-phosphanylidene)-butyl esteracetic acid 4-cyano-3-oxo-1-propyl-4-(triphenyl-λ5-phosphanylidene)-butyl ester tert-butyl-dimethyl-silanyloxy)-3-oxo-2-(triphenyl-λ5-phosphanylidene)-°Ctanenitrile5-(tert-butyl-dimethyl-silanyloxy)-3-oxo-2-(triphenyl-λ5-phosphanylidene)-°Ctanenitrile

丁酰乙酸乙酯置于sodium Tetrahydroborate体系中,用 乙醇 用作溶剂,以81%的收率获得3-羟基己酸乙酯
参考文献:长链β-内酯的合成及其对致病性分枝杆菌的抗菌活性.
标题:长链β-内酯的合成及其对致病性分枝杆菌的抗菌活性.
摘要:为了寻求新的抗菌剂,开发了一系列新颖的长链和中链单和双取代β-内酯.它们针对三种致病性分枝杆菌-M的活性.通过刃天青素微量滴定分析(rema)评估脓肿,海藻分枝杆菌和结核分枝杆菌.在合成的16种β-内酯中,只有3-十六烷基氧杂环丁烷-2-酮(vm005)表现出对脓肿分支杆菌的有希望的活性,而大多数β-内酯表现出了有趣的抗海藻分支杆菌的活性,类似于经典抗生素,异烟肼.关于结核分枝杆菌,发现有六种化合物对这种分枝杆菌有活性,与β-内酯vm008 [反式-(z)-3-(十六烷基-7-烯-1-基)-4-丙基氧杂环丁烷-2-一]是最好的生长抑制剂.
Doi:10.1002/cmdc.201800720

专利信息

专利号:US-2024308950-A1
优先权日:2022-08-05
标题 :Biorenewable synthesis of hydroxy-hexanoate esters
发明人：HUBER GEORGE; DELL ANNA MARCO NAZARENO
权利人:WISCONSIN ALUMNI RES FOUND
摘要:A method to make mono- or di-hydroxy-hexanoates. Triacetic acid lactone is converted to a δ-hexalactone or a 4-hydroxy-δ-hexalactone intermediate. The intermediate is treated with an acid in the presence of an alcohol to yield a 5-hydroxy-hexanoate or 4,5-dihydroxy-hexanoate.

专利号:WO-9706162-A1
优先权日:1995-08-07
标 题:One pot synthesis of 2-oxazolidinone derivatives

专利号:CN-113652407-B
优先权日:2021-07-09
标 题 :Carbonyl reductase mutant and application thereof in asymmetric synthesis of chiral compound

专利号:CN-113652407-A
优先权日:2021-07-09
标 题:Carbonyl reductase mutant and application thereof in asymmetric synthesis of bi-chiral compound