CAS: 2095393-15-8; (2-Chloro-4-Phenoxyphenyl)(4-(((3R,6S)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3-yl)Amino)-3H-Pyrrolo[2,3-D]Pyrimidin-5-yl)Methanone

📜2-氯-4-氟苯腈置于正丁基锂,Sodium Hydride,Potassium Carbonate,N,N-二异丙基乙胺,Potassium Hydroxide体系中,用 四氢呋喃,乙醇,正己烷,N,N-二甲基甲酰胺 用作溶剂,化学反应 13.17H,反应生成化合物arq531
参考文献:テトラヒドロピラニルアミノ−ピロロピリミジノンおよびその使用の方法
标题:テトラヒドロピラニルアミノ−ピロロピリミジノンおよびその使用の方法
摘要:提供一种强效的小分子btk抑制剂,可能用于治疗免疫障碍,癌症,心血管疾病,病毒感染,炎症,代谢/内分泌功能障碍和神经障碍.通过调节btk活性的化合物(i)或其药学上可接受的盐,异构体,前药,溶剂合物,代谢产物,多形体,类似物或衍生物的药学组合物,用于治疗或预防与btk有关的疾病.

专利信息

专利号:US-2024262834-A1
优先权日:2021-05-28
标 题:Synthesis of btk inhibitor and intermediates thereof
发明人：CHEN YONGGANG; CORRY JAMES; DESMOND RICHARD; DI MASO MICHAEL J; FORSTATER JACOB H; KUETHE JEFFREY T; KUHL NADINE; LARSON REED; LEVESQUE FRANCOIS; NARSIMHAN KARTHIK; OTTE DOUGLAS; PRIER CHRISTOPHER K; SHEVLIN MICHAEL; SIROTA ERIC; TAN LUSHI; THAISRIVONGS DAVID A; TURNBULL BEN W H; WANG ZHIXUN; XIAO KAIJIONG
权利人:MERCK SHARP & DOHME LLC
摘要:The present invention relates to efficient synthetic processes useful in the preparation of Compound A, a BTK inhibitor of Formula (I): or a pharmaceutically acceptable salt thereof, including the preparation of intermediates used to make Compound A or a pharmaceutically acceptable salt thereof.

专利号:US-12441733-B2
优先权日:2018-03-26
标题:Substituted 2,4-dioxotetrahydropyrimidines as intermediates in the synthesis of bruton's tyrosine kinase inhibitors
发明人：ARISTA LUCA; HEBACH CHRISTINA; HOLLINGWORTH GREGORY JOHN; HOLZER PHILIPP; IMBACH-WEESE PATRICIA; LORBER JULIEN; MACHAUER RAINER; SCHMIEDEBERG NIKO; VULPETTI ANNA; ZOLLER THOMAS
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formulae (I), (III), (IIIa), (XXIa), (XXIII), and/or (XLVI)or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

专利号:AU-2022280865-A1
优先权日:2021-05-28
标 题 :Synthesis of btk inhibitor and intermediates thereof

专利号:WO-2022251404-A1
优先权日:2021-05-28
标 题:Synthesis of btk inhibitor and intermediates thereof

专利号:AU-2022280865-A9
优先权日:2021-05-28
标 题:Synthesis of btk inhibitor and intermediates thereof

专利号:EP-4347599-A1
优先权日:2021-05-28
标 题:Synthesis of btk inhibitor and intermediates thereof