专利号:US-4140708-A 优先权日:1975-10-16 标 题 :Asymmetric synthesis of optically active prostaglandins 发明人:CHADHA NARESH K; PARTRIDGE JR JOHN J; USKOKOVIC MILAN R 权利人:HOFFMANN LA ROCHE 摘要:An asymmetric synthesis of optically active prostaglandin F 2 α from cyclopentadiene including intermediates in this synthesis.
专利号:US-3933892-A 优先权日:1973-02-12 标题 :Asymmetric synthesis of optically active prostaglandins 发明人:CHADHA NARESH KUMAR; PARTRIDGE JR JOHN JOSEPH; USKOKOVIC MILAN RADOJE 权利人:HOFFMANN LA ROCHE 摘要:An asymmetric synthesis of optically active prostaglandin F 2 .sub.α from cyclopentadiene including intermediates in this synthesis.
专利号:US-5326885-A 优先权日:1992-05-01 标 题 :Process of preparing enriched enantiomers of glycerol carbonate and derivatives thereof for synthesis of β-blockers 发明人:OLIVERO ALAN G; CASSEL JONATHAN M; POULSEN JAMES R 权利人:COGNIS INC 摘要:Enriched enantiomers of glycerol Carbonate are produced under the influence of a hydrolytic enzyme, either by selective esterification of racemic glycerol carbonate or by selective hydrolysis of an ester of the racemate. The enriched enantiomeric product is readily converted to starting materials and intermediates useful in the synthesis of enantiomerically pure therapeutic agents, such as beta -adrenergic blockers.
专利号:US-2009306400-A1 优先权日:2006-03-27 标 题:Convergent process for the synthesis of taxane derivatives. 发明人:HENRI JOHN T; MCCHESNEY JAMES D; VENKATARAMAN SYLESH K; LAMB RODGER L; FOSTER JONATHAN E; SUMNER CHRISTIAN M; YE SHANGPING 权利人:HENRI JOHN T; MCCHESNEY JAMES D; VENKATARAMAN SYLESH K; LAMB RODGER L; FOSTER JONATHAN E; SUMNER CHRISTIAN M; YE SHANGPING 摘要:The present invention is broadly directed to novel compounds useful for the synthesis of biologically active compounds, including taxane derivatives, and convergent processes for the preparation of these taxane derivatives and their intermediates.
专利号:US-5488131-A 优先权日:1994-03-23 标题:Synthesis of compounds with predetermined chirality 发明人:MYERS ANDREW G 权利人:CALIFORNIA INST OF TECHN 摘要:A method for synthesizing enantiomerically enriched chemical intermediates with predetermined chirality is described. The method comprises formation of a pseudoephedrine amide, followed by stereoselective alkylation at the alpha carbon. The chiral auxiliary can then be cleaved off, affording chiral end products useful for further transformations. The enantiomeric enrichment of the chiral end products may exceed 98%, and the chiral auxiliary can be recovered. Novel amides of pseudoephedrine used in this method are also disclosed.
专利号:US-2023357257-A1 优先权日:2020-12-28 标 题 :Novel process for the synthesis of noroxymorphone from morphine 发明人:GORBACHEV DMITRY; LAM HON WAI; SAXENA AAKARSH; SAXENA NAVIN SATYAPAL 权利人:NAVIN SAXENA RESEARCH & TECH PVT LTD 摘要:The present invention relates to a novel, efficient, pot- and atom-economical, and industrially applicable process for converting morphine to noroxymorphone using reagents and solvents of lesser toxicity and lower cost with respect to those used in the prior art.
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合成参考文献
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