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参考文献:Aza And Aza (N-Oxy) Analogs Of Glycine/nmda Receptor Antagonists
标题:Aza And Aza (N-Oxy) Analogs Of Glycine/nmda Receptor Antagonists
摘要:治疗或预防与中风,缺血,中枢神经系统创伤,低血糖和手术相关的神经元丢失的方法,以及治疗包括阿尔茨海默病,肌萎缩侧索硬化,亨廷顿病和唐氏综合征在内的神经退行性疾病,治疗或预防兴奋性氨基酸过度活跃的不良后果,以及治疗焦虑,慢性疼痛,抽搐,诱导麻醉,以及治疗或预防阿片类药物耐受性的方法是通过向需要此类治疗或预防的动物施用取代或未取代的吡啶和吡啶(n-氧化物)类似物的4-羟基二氢喹啉酮,四氢喹啉三酮肟和喹啉酮,其互变异构体和药学上可接受的盐,这些物质对甘氨酸受体具有高结合能力.

专利信息

专利号:US-9957277-B2
优先权日:2015-11-25
标题 :eIF4A-inhibiting compounds and methods related thereto
发明人：ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; TRAN CHINH VIET; PACKARD Garrick Kenneth; XIANG ALAN X; NILEWSKI CHRISTIAN; MICHELS THEO
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds X, Y, R 1 , R 2 , R 3a , R 3b , R 4a , R 4b and R 5 are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4A and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.