CAS: 142137-17-5; 3-Bromo-5-Phenylpyridine

相似化合物

4422-32-6 129013-83-8 675590-28-0

上下游产品

CAS号625-92-3 3,5-二溴吡啶 | CAS号98-80-6 苯硼酸 | CAS号110-71-4 乙二醇二甲醚 | CAS号591-50-4 碘苯 | CAS号497-19-8 纯碱 | CAS号13535-01-8 3-氨基-5-溴吡啶 | CAS号73183-34-3 双戊酰二硼 | CAS号850991-38-7 5-苯基-3-吡啶基硼酸 | CAS号92-07-9 3,5-二苯基吡啶

3-苯基吡啶置于2,4,6-三甲基吡啶,N-溴代丁二酰亚胺(Nbs),三氟乙酸体系中,用 乙酸乙酯 用作溶剂,化学反应 1.5H,反应生成3-溴-5-苯基吡啶
参考文献:通过锌亚胺中间体卤化吡啶的3位
标题:通过锌亚胺中间体卤化吡啶的3位
摘要:吡啶卤化反应对于获得药物和农用化学品开发所需的大量衍生物至关重要.然而,尽管经过一个多世纪的合成努力,选择性官能化多种吡啶前体 3 位碳氢键的卤化过程在很大程度上仍然难以捉摸.我们报道了吡啶基开环,卤化和闭环的反应序列,其中无环锌亚胺中间体在温和条件下经历高度区域选择性卤化反应.实验和计算机理研究表明,卤素亲电子试剂的性质可以改变选择性决定步骤.使用这种方法,我们生产了多种 3-卤代吡啶,并演示了复杂药物和农用化学品的后期卤化.
Doi:10.1126/science.Add8980

专利信息

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-2009275616-A1
优先权日:2008-04-30
标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues