CAS: 14003-66-8; 4-Methyl-5-Nitro-1H-Imidazole

相似化合物

49780-25-8 57658-79-4 79681-02-0

上下游产品

CAS号822-36-6 4-甲基咪唑 | CAS号105983-46-8 2-bromo-5-methy... | CAS号302-72-7 DL-2-氨基丙酸 | CAS号25271-84-5 5-甲基-1H-咪唑-4-胺 | CAS号7664-41-7 氨 | CAS号7464-68-8 1,5-二甲基-4-硝基咪唑 | CAS号57658-79-4 1,4-二甲基-5-硝基咪唑

📜5-Methyl-1,4-Dinitro-1H-Imidazole置于一水合肼体系中,用52%的收率获得4-甲基-5-硝基咪唑
参考文献:1,4-二硝基咪唑与肼的反应
标题:1,4-二硝基咪唑与肼的反应
摘要:2-甲基-1,4-二硝基咪唑与肼的反应导致咪唑环的膨胀和1,2,4-三嗪衍生物的形成.1,4-二硝基咪唑与n-氨基吗啉的反应通过咪唑环的变性转化产生1-(n-吗啉代)-4-硝基咪唑.用叔丁氧基羰基肼处理1,4-二硝基咪唑会导致咪唑环的断裂和乙二醛二hydr衍生物的形成.通过x射线分析确定代表性的杂环产物的结构.
Doi:10.1016/0040-4020(96)00903-9

专利信息

专利号:US-7393954-B2
优先权日:2002-12-12
标题:Process for the production of pentostatin aglycone and pentostatin
发明人：NADJI SOURENA; SMOOT JAMES; SAMPATH UMASHANKER
权利人:RELIABLE BIOPHARMACEUTICAL COR
摘要:A novel, scaleable and improved process for preparing pentostatin and its analogs is disclosed. The method comprises the diastereospecific synthesis of the nucleobase from commercially available L-Dialkyl tartarates.

专利号:US-6992097-B2
优先权日:1998-08-18
标 题 :Growth hormone secretagogues
发明人：HAUSER KENNETH LEE; DODGE JEFFREY ALAN; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR III CHARLES WILLIS; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROGER LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:EP-1670809-B1
优先权日:2003-09-15
标 题:Synthesis and manufacture of pentostatin and its precursors, analogs and derivatives
发明人：PHIASIVONGSA PASIT; REDKAR SANJEEV
权利人:MAYNE PHARMA PLC