CAS: 13460-98-5; Theodrenaline

该化合物是一种纯衍生物,具有核素基和苯球化合物特性.该化合物具有一种复杂的结构,包括一种纯环系统,它是生物化学学的基础,特别是在核酸和ATP等能量转移分子的情况下.多种氢基化合物的存在表明氢联结的潜力和极溶剂溶性增加.其氨基乙基边链可能有助于其生物活动,可能影响与生物巨型分子的相互作用.该化合物对药理学和药用化学具有兴趣,因为对纯基结构的修改可以导致各种治疗应用,包括作为抑制剂或调节剂在生物化学途径中的作用.

结构式图片

物理性质

MSDS等安全信息

    合成工艺路线路线简述

      📜7-[2-[[4-[2-[3,4-Bis(Phenylmethoxy)Phenyl]-2-Oxoethyl]Phenyl]Methylamino]Ethyl]-1,3-Dimethylpurine-2,6-Dione 反应生成7-[2-[[2-(3,4-二羟基苯基)-2-羟基乙基]氨基]乙基]-3,7-二氢-1,3-二甲基-1H-嘌呤-2,6-二酮
      参考文献:Klingler,K.-H.;Bickel,E.
      标题:Klingler,K.-H.;Bickel,E.

      海关参考信息

      专利信息


      专利号:US-2023271983-A1
      优先权日:2020-07-29
      标题 :Functionalized isonitriles and products, preparation and uses thereof
      发明人：SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
      权利人:UNIV SANTIAGO COMPOSTELA
      摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

      其他信息查阅

      供应商参考报价(招募中)

      品牌试剂参考报价(招募中)

      实用工具

      ⚠️全国化工行业净网倡议书
      📋制造商识别码
      📖 海关编码查询
      📝MSDS生成器

      📌 第三方产品分析报告

      ✅ COA系统入驻 | 共享模式

      主要参考文献


      1: Bein B, Christ T, Eberhart LH. Cafedrine/Theodrenaline (20:1) Is an Established Alternative for the Management of Arterial Hypotension in Germany-a Review Based on a Systematic Literature Search. Front Pharmacol. 2017 Feb 21;8:68. doi: 10.3389/fphar.2017.00068.
      2: Weitzel M, Hammels P, Schorer C, Klingler H, Weyland A. Hämodynamisches Wirkungsspektrum von Cafedrin/Theodrenalin bei Anästhesie-assoziierter Hypotension [Hemodynamic effects of cafedrine/theodrenaline on anesthesia- induced hypotension]. Anaesthesist. 2018 Oct;67(10):766-772. German. doi: 10.1007/s00101-018-0472-z. Epub 2018 Aug 21. 64(3):190-6. doi: 10.1007/s00101-015-0005-y. Epub 2015 Mar 11.
      4: Eberhart L, Geldner G, Kowark A, Zucker TP, Kreuer S, Przemeck M, Huljic S, Koch T, Keller T, Weber S, Kranke P; HYPOTENS study group. Treatment of intraoperative hypotension with cafedrine/theodrenaline versus ephedrine : A prospective, national, multicenter, non-interventional study-the HYPOTENS trial. Anaesthesist. 2020 Nov 10. English. doi: 10.1007/s00101-020-00877-5. Epub ahead of print. Erratum in: Anaesthesist. 2021 Feb 26;:

      合成参考文献


      参考文献:10.1007/s00101-009-1673-2
      摘要:Wallenborn J; German Society for Anesthesiology and Intensive Care Medicine; Professional Association of German Anesthetists; German Society for Gynecology and Obstetrics. [Execution of analgesia and anesthesia procedures in obstetrics : Second revised recommendations of the German Society for Anesthesiology and Intensive Care Medicine and the Professional Association of German Anesthetists in cooperation with the German Society for Gynecology and Obstetrics]. Anaesthesist. 2010 Mar;59(3):250–4. doi: 10.1007/s00101-009-1673-2.
      📝 需求与反馈
      尽可能描述清楚需求与问题信息
      ×

      通知