CAS: 119302-91-9; 1-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-Acetoxy-3-Hydroxy-10,13-Dimethyl-2-Morpholinohexadecahydro-1H-Cyclopenta[a]Phenanthren-16-yl)-1-Allylpyrrolidin-1-Ium Bromide

2α,3α-Epoxy-5α-Androstan-17-One置于iron(III) Chloride,Sodium Tetrahydroborate,Sodium Carbonate,三乙胺,Copper(Ll) Bromide体系中,用 甲醇,二氯甲烷,水,乙腈 用作溶剂,化学反应 108.5H,反应生成罗库溴铵
参考文献:一种新的合成罗库溴铵的有效方法
标题:一种新的合成罗库溴铵的有效方法
摘要:溴化罗库溴铵已用作氨基类固醇非去极化神经肌肉阻滞剂和肌肉松弛剂.在这项工作中,通过开环开环,开发了一种新的有效途径来制备关键的中间体2β-(4-吗啉基)-16β-(1-吡咯烷基)-5α-雄烷-3α,17β-二醇(6).环氧化物,然后引入吡咯烷.化合物6可以轻松提供罗库溴铵,并且5步化合物6的总收率提高到57.8%,高于目前报道的方法.特别地,该方法将避免难以去除的二取代杂质e和f的产生.
Doi:10.1016/j.Cclet.2016.10.026

专利信息

专利号:US-2022169753-A1
优先权日:2019-03-29
标 题:An improved process for preparation of sugammadex acid and sugammadex sodium
发明人：SRIDHAR BHUVANESWARI; KUDAVALLI JAYA SATYANARAYANA; MEDABALIMI PETERPAUL RAJU; REMALA NAGA MALLESH; DEVINENI SURESH; RAMACHANDRAN GURURAJ; JAGANATHAN THANNEERPANDALPUDUR SRINIVASAN; KALIAPERUMAL KARTHIKEYAN
权利人:HOSPIRA INC
摘要:The present disclosure provides an improved process for the synthesis of suganmmadex acid and suganmmadex sodium.

专利号:US-7579461-B2
优先权日:2004-01-15
标题:Processes for the preparation of rocuronium bromide and intermediates thereof
发明人：ADAR ELIEZER; SONDACK DAVID; FRIEDMAN ODED; MANASCU IOSEF; FIZITZKI TAMIR; FREGER BORIS; ARAD ODED; WEISMAN ALEXANDER; KASPI JOSEPH
权利人:CHEMAGIS LTD
摘要:A novel process for preparing (2β,3α,5α,16β,17β)-17-acetoxy-3-hydroxy-2-(4-morpholinyl)-16-(1-pyrrolidinyl) androstane, a known intermediate in the synthesis of the skeletal muscle relaxant rocuronium bromide, is disclosed.

专利号:WO-2016009442-A1
优先权日:2014-07-14
标 题 :Novel method for synthesis of neuromuscular blocking agents
发明人：DALVI MAHESH BHAGOJI; TARADE PRADEEP KISAN
权利人:NEON LAB LTD
摘要:The invention discloses a novel method for preparing neuromuscular blocking agents using aryl esters as a reagent of di-acylation as well as highly regioselective mono-acylation of androstane-diols.

专利号:US-2007117975-A1
优先权日:2005-09-13
标 题 :Processes for the synthesis of rocuronium bromide

专利号:US-2009093632-A1
优先权日:2005-09-13
标题:Processes for the synthesis of rocuronium bromide

专利号:US-2009137794-A1
优先权日:2005-09-13
标题 :Processes for the synthesis of rocuronium bromide