CAS: 112525-72-1; 2-((Tert-Butoxycarbonyl)Amino)-3-(1H-Indol-3-yl)Propanoic Acid

该化合物是一种受保护的突变衍生物,其特点是氨基功能的三丁基碳基(Boc) 组,该化合物在peptide合成中广泛使用, Boc组在这种合成中充当α-氨基动物的临时保护组,在温酸条件下能够有选择地减少保护.它的无花边链仍然对进一步修改做出反应,使其在复杂的peptides和生物活性分子的制作过程中具有价值. 受波茨保护的试变衍生物在合成过程中增强了稳定性,最大限度地减少了不想要的副作用. 它的纯度和一贯性表现使得研究人员在医药化学和药物开发方面享有优先选择权.

结构式图片

相似化合物

13139-14-5 143824-78-6 144599-95-1

上下游产品

1-tert-butoxycarbonyloxybenzotriazole Trp tert-butyl dicarbonatedi-tert-butyl dicarbonate 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrileNα-tert-butoxycarbonyl-tryptophylamino)-3-(1-methyl-2-phenyl-ethyl)-[1,2,3]oxadiazolium betaine5-(Nα-tert-butoxycarbonyl-tryptophylamino)-3-(1-methyl-2-phenyl-ethyl)-[1,2,3]oxadiazolium betaine 3,8-Bis-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-5-ethyl-6-phenyl-phenanthridinium; bromide 2-t-butoxycarbonylamino-3-(1H-indol-3-yl)-N-(2-methoxybenzyl)-propanamide (RS)-N-(2-chlorobenzyl)-2,5-dioxo-3-(1H-indol-3-ylmethyl)piperazine

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    海关参考信息

    专利信息


    专利号:US-2007179279-A1
    优先权日:2005-12-30
    标题:Methods for the synthesis of arginine-containing peptides
    发明人:CHEN LIN; ROBERTS CHRISTOPHER R
    权利人:CHEN LIN; ROBERTS CHRISTOPHER R
    摘要:Methods for the synthesis of arginine-containing peptides are provided. The methods include a step that minimizes contact of side chain protected arginine with base prior to the coupling step.

    专利号:US-12378196-B2
    优先权日:2018-12-11
    标 题 :Synthesis of (S)-6-hydroxytryptophan and derivatives thereof
    发明人:SIMON WERNER; WERNER-SIMON SUSANNE; MüLLER CHRISTOPH
    权利人:HEIDELBERG PHARMA RES GMBH
    摘要:The present invention relates to novel methods and compounds for synthesizing amanitin derivatives. The invention in particular relates to methods for synthesizing (S)-6-hydroxy-tryptophan derivatives which can be used as building blocks for synthesizing amanitin derivatives or amatoxin drug conjugates. The invention further relates to intermediate compounds of said synthesis pathways for use in amanitin derivative and amatoxin drug conjugate synthesis, and to the use of particular catalysts suited for mediating said synthesis pathways.

    专利号:US-3974135-A
    优先权日:1971-06-24
    标题:Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for producing the same
    发明人:FOLKERS KARL; SIEVERTSSON HANS
    权利人:FOLKERS KARL; SIEVERTSSON HANS
    摘要:A synthetic decapeptide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide having the hormonal activity of the luteinizing hormone releasing hormone (LRH) of the hypothalamus gland of mammals is provided by utilizing, as key starting materials, the amino acids, pyroglutamic acid, histidine, tryptophan, serine, tyrosine, glycine, leucine, arginine, proline. Synthesis of the decapeptide is accomplished by coupling, in appropriate protected forms, all of the remaining amino acids, individually or in combination, to the starting amino acid, or amino acid group or to the terminal amino acid resulting from combinations with one or more other amino acids, bound to a resin or carrier followed by release of the decapeptide from the carrier as the amide or other form which is converted to the amide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide.

    专利号:US-9085511-B2
    优先权日:2011-04-04
    标题:Atropisomeric 1,8-bisphenolnapthalenes and their use in enantioselective recognition and asymmetric synthesis
    发明人:WOLF CHRISTIAN; GHOSN MARWAN
    权利人:WOLF CHRISTIAN; GHOSN MARWAN; UNIV GEORGETOWN
    摘要:This invention related to atropisomeric 1,8-bisphenolnaphthalenes and derivatives thereof of the general formula (I): n nwhich are useful in resolution of enantiomers, enantioselective recognition and asymmetric synthesis.

    专利号:EP-1968995-A1
    优先权日:2005-12-30
    标 题:Methods for the synthesis of arginine-containing peptides

    专利号:WO-2020120525-A1
    优先权日:2018-12-11
    标题 :Synthesis of (s)-6-hydroxytryptophan and derivatives thereof

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 251.
    参考文献:10.1016/j.bbagen.2006.05.001
    摘要:Gąsowska B, Frąckowiak B, Wojtasek H. Indirect oxidation of amino acid phenylhydrazides by mushroom tyrosinase. Biochimica et Biophysica Acta (BBA) - General Subjects. 2006 Sep;1760(9):1373–9. doi: 10.1016/j.bbagen.2006.05.001.
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