专利号:US-2007179279-A1 优先权日:2005-12-30 标题:Methods for the synthesis of arginine-containing peptides 发明人:CHEN LIN; ROBERTS CHRISTOPHER R 权利人:CHEN LIN; ROBERTS CHRISTOPHER R 摘要:Methods for the synthesis of arginine-containing peptides are provided. The methods include a step that minimizes contact of side chain protected arginine with base prior to the coupling step.
专利号:US-12378196-B2 优先权日:2018-12-11 标 题 :Synthesis of (S)-6-hydroxytryptophan and derivatives thereof 发明人:SIMON WERNER; WERNER-SIMON SUSANNE; MüLLER CHRISTOPH 权利人:HEIDELBERG PHARMA RES GMBH 摘要:The present invention relates to novel methods and compounds for synthesizing amanitin derivatives. The invention in particular relates to methods for synthesizing (S)-6-hydroxy-tryptophan derivatives which can be used as building blocks for synthesizing amanitin derivatives or amatoxin drug conjugates. The invention further relates to intermediate compounds of said synthesis pathways for use in amanitin derivative and amatoxin drug conjugate synthesis, and to the use of particular catalysts suited for mediating said synthesis pathways.
专利号:US-3974135-A 优先权日:1971-06-24 标题:Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for producing the same 发明人:FOLKERS KARL; SIEVERTSSON HANS 权利人:FOLKERS KARL; SIEVERTSSON HANS 摘要:A synthetic decapeptide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide having the hormonal activity of the luteinizing hormone releasing hormone (LRH) of the hypothalamus gland of mammals is provided by utilizing, as key starting materials, the amino acids, pyroglutamic acid, histidine, tryptophan, serine, tyrosine, glycine, leucine, arginine, proline. Synthesis of the decapeptide is accomplished by coupling, in appropriate protected forms, all of the remaining amino acids, individually or in combination, to the starting amino acid, or amino acid group or to the terminal amino acid resulting from combinations with one or more other amino acids, bound to a resin or carrier followed by release of the decapeptide from the carrier as the amide or other form which is converted to the amide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide.
专利号:US-9085511-B2 优先权日:2011-04-04 标题:Atropisomeric 1,8-bisphenolnapthalenes and their use in enantioselective recognition and asymmetric synthesis 发明人:WOLF CHRISTIAN; GHOSN MARWAN 权利人:WOLF CHRISTIAN; GHOSN MARWAN; UNIV GEORGETOWN 摘要:This invention related to atropisomeric 1,8-bisphenolnaphthalenes and derivatives thereof of the general formula (I): n nwhich are useful in resolution of enantiomers, enantioselective recognition and asymmetric synthesis.
专利号:EP-1968995-A1 优先权日:2005-12-30 标 题:Methods for the synthesis of arginine-containing peptides
专利号:WO-2020120525-A1 优先权日:2018-12-11 标题 :Synthesis of (s)-6-hydroxytryptophan and derivatives thereof
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 251. 参考文献:10.1016/j.bbagen.2006.05.001 摘要:Gąsowska B, Frąckowiak B, Wojtasek H. Indirect oxidation of amino acid phenylhydrazides by mushroom tyrosinase. Biochimica et Biophysica Acta (BBA) - General Subjects. 2006 Sep;1760(9):1373–9. doi: 10.1016/j.bbagen.2006.05.001.