3-甲基吡啶置于双氧水体系中,用 甲醇 用作溶剂,化学反应 0.05H,以99%的收率获得3-甲基吡啶氧化物 参考文献:连续流微反应器促进吡啶衍生物的催化n-氧化反应 标题:连续流微反应器促进吡啶衍生物的催化n-氧化反应 摘要:成功构建了一个简单的连续流动微反应器,用于吡啶的n-氧化.连续流动微反应器使用填充床微反应器中的钛硅沸石 (Ts-1) 和 H 2 O 2 (在甲醇中作用作溶剂)作为催化氧化系统,以高达 99% 的收率形成各种吡啶n-氧化物.与使用间歇反应器相比,该工艺是一种更安全,更环保,更高效的工艺.该装置连续运行800小时以上,催化剂保持非常好的活性,为规模化生产提供了巨大潜力. Doi:10.1055/s-0041-1737490
专利信息
专利号:US-6664277-B1 优先权日:2002-08-14 标题:Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use 发明人:BROWN BRADLEY B; REHDER KENNETH S; STRACHAN JON-PAUL; EAVES JERON H; LOWDEN CHRISTOPHER T 权利人:PPD DISCOVERY INC 摘要:The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
专利号:CN-114315699-A 优先权日:2022-01-14 标 题 :A kind of method for copper-catalyzed synthesis of 2-alkenyl pyridine compounds
专利号:CN-114315699-B 优先权日:2022-01-14 标 题:A method for copper-catalyzed synthesis of 2-alkenylpyridine compounds
专利号:US-2008187575-A1 优先权日:2004-08-27 标题:Pyrimidine Derivatives 发明人:KLEBL BERT; BAUMANN MATTHIAS; HOPPE EDMUND; BREHMER DIRK; DAUB HENRIK; KERI GYORGY; VARGA ZOLTAN; MAROSFALVI JENO; ORFI LASZLO 权利人:KLEBL BERT; BAUMANN MATTHIAS; HOPPE EDMUND; BREHMER DIRK; DAUB HENRIK; KERI GYORGY; VARGA ZOLTAN; MAROSFALVI JENO; ORFI LASZLO 摘要:The present invention relates to pyrimidine derivatives, methods for their synthesis, and the use of said pyrimidine derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of cell proliferation disorders, cancer, leukemia, erectile dysfunction, cardiovascular diseases and disorders, inflammatory diseases, transplant rejection, immunological diseases, neuroimmunological diseases, autoimmune diseases, infective diseases including opportunistic infections, prion diseases and/or neuro-degeneration. Furthermore, the present invention relates to pharmaceutical compositions containing at least one pyrimidine derivative and/or pharmaceutically acceptable salts thereof as an active ingredient together with at least one pharmaceutically acceptable carrier, excipient or diluents as well as to methods for prophylaxis and/or treatment of the above-mentioned diseases and disorders.
专利号:CN-115160220-A 优先权日:2022-08-06 标 题 :A kind of synthesis technique of pyridine-N-oxide
专利号:US-4222962-A 优先权日:1978-12-11 标 题:Process for preparing a substituted diphenoxybenzene 发明人:PELLEGRINI JR JOHN P 权利人:GULF RESEARCH DEVELOPMENT CO 摘要:A diaminophenoxy or a dinitrophenoxybenzene is prepared in good yield from dibromobenzene and an alkali metal salt of meta-aminophenol or meta-nitrophenol under Ullmann ether synthesis conditions at low temperatures of 115° C. to 150° C.
摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 280. 摘要:Ye, Z.-S., Science of Synthesis Knowledge Updates, (2021) 2, 410. 摘要:Schafer, E. W., Jr., W. A. Bowles Jr., and J. Hurlbut. 1983. The acute oral toxicity and repellency and hazard potential of 998 chemicals to one or more species of wild and domestic birds. Archives of Environmental Contamination and Toxicology 12:355-382. 摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 2004. Toxicity, Repellency of Phytotoxicity of 979 Chemicals to Birds, Mammals and Plants. Research Report No. 04-01. National Wildlife Research Center, Fort Collins, Colorado. 118 pp. https://www.aphis.usda.gov/ws/nwrc/chem-effects-db/U_schafer041_2004.pdf