CAS: 820-10-0; Butyric Acid, 2-Amino-4-(Methylsulfonyl)-, Dl

该化合物是氨酸甲基硫磷的硫酸衍生物,其特征是存在一个全氟辛烷磺酸功能组,由硫磺原子结合成两个氧原子和二个碳原子组成,该化合物作为种族混合物存在,意思是它含有相等量的对应物,可以显示不同的生物活动.甲基硫磺通常是一种白色晶状固体,在水中可溶解,适合各种生物化学应用.它经常用于与氨酸新陈代谢有关的研究,可以作为研究全氟辛烷磺酸反应的模型化合物.此外,它也可以在其他生物活性化合物合成中发挥作用.它的稳定性和活性受到可参与各种化学反应的全氟辛烷磺酸组的存在的影响,包括核糖分泌替代和氧化过程.

结构式图片

物理性质

MSDS等安全信息

上下游产品

CAS号59-51-8 DL-蛋氨酸 | CAS号3226-65-1 L-蛋氨酸亚砜 | CAS号100453-86-9 acetylamino-(2-... | CAS号7722-84-1 过氧化氢 | CAS号7314-32-1 L-蛋氨酸砜 | CAS号41486-92-4 HD-Met(O2)-OH

合成工艺路线路线简述

  • 59-51-8 = 820-10-0
    反应条件:1.1 Reagents: Acetic Acid,Hydrogen Peroxide Solvents: Water; 60 °C; 3 H,70 °C
    标题:Reactions 2-Amino-4-(Methylthio)Butanoic Acid And Its Analogs With Phenyl Isothiocyanate
    作者:Strunin,B. P.; Maslennikov,E. I.; Guseinov,F. I.; Sapozhnikov,Yu. E.
    参考文献:Bashkirskii Khimicheskii Zhurnal 日期:2003 卷标:10(3) 页码:19-21]

    59-51-8 = 820-10-0
    反应条件:1.1 Reagents: Chloramine B
    标题:Oxidation Of Methionine By Sodium N-Chlorobenzene Sulphonamide In Hydrochloric Acid Medium: A Kinetic Study
    作者:Mallamma; Ananda,S.; Rangaswamy
    参考文献:Asian Journal Of Chemistry 日期:2001 卷标:13(2) 页码:543-549]

    59-51-8 = 820-10-0
    反应条件:1.1 Catalysts: 2,2,2-Trifluoroethaneperoxoic Acid
    标题:Peroxytrifluoroacetic Acid Oxidation Of Sulfides To Sulfoxides And Sulfones
    作者:Venier,Clifford G.; Squires,Thomas G.; Chen,Yu Ying; Smith,Barbara F.
    参考文献:Journal Of Organic Chemistry 日期:1982 卷标:47(19) 页码:3773-4]

    62697-73-8 = 820-10-0
    反应条件:1.1 Solvents: Water; 90 °C1.2 Reagents: Hydrogen Peroxide Solvents: Water; 1 H,90 °C
    标题:Optimization Of Conditions For Synthesis Of 1-Amino-3-(Methylsulfinyl)Propane Carboxylic Acid
    作者:Strunin,B. P.; Maslennikov,E. I.; Gusyejnov,F. I.; Sapozhnikov,Yu. E.
    参考文献:Bashkirskii Khimicheskii Zhurnal 日期:2002 卷标:9(1) 页码:39-40]

    63-68-3 = 820-10-0
    反应条件:1.1 Reagents: Sodium Hydroxide,1-(P-Toluenesulfonyl)Imidazole,Hydrogen Peroxide Solvents: Methanol,Water
    标题:Sulfonic Peracids. Iii. Heteroatom Oxidation And Chemoselectivity
    作者:Kluge,R.; Schulz,M.; Liebsch,S.
    参考文献:Tetrahedron 日期:1996 卷标:52(16) 页码:5773-82]

    59-51-8 = 820-10-0
    反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: 2362518-85-0 Solvents: Water; 35 Min,50 °C
    标题:Peroxo-Cerium(Iv)-Containing Polyoxometalates: [ceiv6(O2)9(Gew10O37)3]24-,A Recyclable Homogeneous Oxidation Catalyst
    作者:Qasim,Hafiz M.; Ayass,Wassim W.; Donfack,Patrice; Mougharbel,Ali S.; Bhattacharya,Saurav; Et Al
    参考文献:Inorganic Chemistry 日期:2019 卷标:58(17) 页码:11300-11307]

    59-51-8 = 820-10-0 + 62697-73-8
    反应条件:1.1 Reagents: Hydrogen Peroxide
    标题:The Biosynthesis Of The Aroma Volatile 2-Methyltetrahydrothiophen-3-One In The Bacterium Chitinophaga Fx7914
    作者:Nawrath,Thorben; Gerth,Klaus; Mueller,Rolf; Schulz,Stefan
    参考文献:Chembiochem 日期:2010 卷标:11(13) 页码:1914-1919
📜Acetylamino-(2-Methanesulfonyl-Ethyl)-Malonic Acid Diethyl Ester置于盐酸体系中,化学反应生成 Dl-蛋氨酸砜
参考文献:Kaneko; Inui,Nippon Kagaku Zasshi,1955,Vol. 76,P. 306,308
标题:Kaneko; Inui,Nippon Kagaku Zasshi,1955,Vol. 76,P. 306,308

海关参考信息

专利信息


专利号:US-7060818-B2
优先权日:2003-02-21
标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
发明人：HORWITZ COLIN P; GHOSH ANINDYA
权利人:UNIV CARNEGIE MELLON
摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.

专利号:US-6011152-A
优先权日:1996-07-22
标 题 :Synthesis of macrocyclic tetraamido-N ligands

专利号:CN-113636931-B
优先权日:2021-08-05
标题:Starting head fragment compound of genetically encoded compound library and its application in the synthesis of genetically encoded compound library

专利号:US-2004167329-A1
优先权日:2003-02-21
标 题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process

专利号:WO-2004076425-A1
优先权日:2003-02-21
标题:Improved synthesis of macrocyclic tetraamido compounds and new metal insertion process

专利号:CN-113636931-A
优先权日:2021-08-05
标题 :Gene-encoded compound library starting head fragment compound and its application in the synthesis of gene-encoded compound library

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主要参考文献


1: Latimer MN, Freij KW, Cleveland BM, Biga PR. Physiological and Molecular Mechanisms of Methionine Restriction. Front Endocrinol (Lausanne). 2018 May 4;9:217. doi: 10.3389/fendo.2018.00217. eCollection 2018. Review.
2: Chaturvedi S, Hoffman RM, Bertino JR. Exploiting methionine restriction for cancer treatment. Biochem Pharmacol. 2018 May 4;154:170-173. doi: 10.1016/j.bcp.2018.05.003. [Epub ahead of print] Review.

合成参考文献


参考文献:10.4061/2011/486928
摘要:Magdaleno A, Suárez Mantilla B, Rocha SC, Pral EMF, Silber AM. The Involvement of Glutamate Metabolism in the Resistance to Thermal, Nutritional, and Oxidative Stress in Trypanosoma cruzi. Enzyme Research. 2011 Apr 10;2011():1–13. doi: 10.4061/2011/486928.
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